Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang ZM et al. | Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. | 2002 | Ai Zheng | pmid:12508652 |
Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP]. | 2008 | Ai Zheng | pmid:19079988 |
Ma GD et al. | [Role of histone deacetylase in inhibiting invasion of human gastric carcinoma cell line SGC-7901 by PPARgamma-mediated pathway]. | 2009 | Ai Zheng | pmid:19624894 |
Hong ZY et al. | [Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. | 2006 | Ai Zheng | pmid:16965673 |
Turaga RV et al. | Werner syndrome protein prevents DNA breaks upon chromatin structure alteration. | 2007 | Aging Cell | pmid:17521388 |
Calvert S et al. | A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. | 2016 | Aging Cell | pmid:26676933 |
Chu F et al. | Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway. | 2008 | Aging Cell | pmid:18489729 |
Karagiannis TC et al. | Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes. | 2010 | Aging (Albany NY) | pmid:20930262 |
Peidis P et al. | HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2. | 2010 | Aging (Albany NY) | pmid:21076179 |
Sancho-Pelluz J and Paquet-Durand F | HDAC inhibition prevents Rd1 mouse photoreceptor degeneration. | 2012 | Adv. Exp. Med. Biol. | pmid:22183322 |
Kovács P et al. | Effect of histone deacetylase inhibitor trichostatin A (TSA) on the microtubular system of Tetrahymena. | 2007 | Acta. Biol. Hung. | pmid:18277464 |
Shim SH et al. | Histone deacetylase inhibitors suppress coxsackievirus B3 growth in vitro and myocarditis induced in mice. | 2013 | Acta Virol. | pmid:24294962 |
Dai Q et al. | Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. | 2016 | Acta Pharmacol. Sin. | pmid:26775659 |
Wu J et al. | Trichostatin A sensitizes cisplatin-resistant A549 cells to apoptosis by up-regulating death-associated protein kinase. | 2010 | Acta Pharmacol. Sin. | pmid:20048748 |
Szablowska-Gadomska I et al. | Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood. | 2012 | Acta Neurobiol Exp (Wars) | pmid:23377265 |
Liu H et al. | Inhibition of class II histone deacetylase blocks proliferation and promotes neuronal differentiation of the embryonic rat neural progenitor cells. | 2012 | Acta Neurobiol Exp (Wars) | pmid:23377267 |
Smetana K et al. | Effect of histone deacetylase inhibitors on the cell nucleus and nucleolus of leukemic myeloblasts in vitro - a cytochemical study. | 2007 | Acta Histochem. | pmid:17559910 |
Jiang H et al. | Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process. | 2015 | Acta Histochem. | pmid:25480399 |
Rombouts K et al. | Trichostatin A, lead compound for development of antifibrogenic drugs. | 2001 Jul-Sep | Acta Gastroenterol. Belg. | pmid:11680040 |
Zhang C et al. | An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering. | 2018 | Acta Biomater | pmid:28963019 |