trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Ganglioneuroma D005729 2 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Chromosome Inversion D007446 1 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Lupus Vulgaris D008177 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Chen YX et al. Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. 2004 World J. Gastroenterol. pmid:15309711
Myzak MC et al. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. 2004 Cancer Res. pmid:15313918
Facchetti F et al. Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. 2004 Apoptosis pmid:15314285
Roh MS et al. Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. 2004 Apoptosis pmid:15314286
Schultz BE et al. Kinetics and comparative reactivity of human class I and class IIb histone deacetylases. 2004 Biochemistry pmid:15323567
Chiba T et al. Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. 2004 J. Hepatol. pmid:15336447
Liu CJ et al. Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. 2004 J. Biol. Chem. pmid:15337766
Cosio BG et al. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. 2004 J. Exp. Med. pmid:15337792
Tao D et al. Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. 2004 Acta Biochim. Biophys. Sin. (Shanghai) pmid:15346199
Korkmaz CG et al. Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants. 2004 J. Endocrinol. pmid:15350180
Tang XX et al. Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma. 2004 Clin. Cancer Res. pmid:15355914
Yokota T et al. Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene. 2004 FEBS Lett. pmid:15358560
Boehrer S et al. In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. 2004 Leuk. Lymphoma pmid:15359646
Vaghefi H and Neet KE Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. 2004 Oncogene pmid:15361854
Moore PS et al. Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. 2004 Biochim. Biophys. Acta pmid:15363630
Laeng P et al. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. 2004 J. Neurochem. pmid:15379904
Kim MK and Carroll WL Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2. 2004 Cancer pmid:15382088
Davis FJ et al. Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15388503
Chen JS and Faller DV Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. 2005 J. Cell. Physiol. pmid:15389542
Frønsdal K and Saatcioglu F Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. 2005 Prostate pmid:15389787
Fan X et al. Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. 2004 J. Cell. Biochem. pmid:15389882
Zelko IN and Folz RJ Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. 2004 Free Radic. Biol. Med. pmid:15451065
Chiba T et al. Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. 2004 Oncology pmid:15452378
Jose B et al. Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones. 2004 Bioorg. Med. Chem. Lett. pmid:15454224
Uramoto H et al. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. 2004 J. Cell. Sci. pmid:15454570
Heltweg B et al. Subtype selective substrates for histone deacetylases. 2004 J. Med. Chem. pmid:15456267
Sarg B et al. Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation. 2004 J. Biol. Chem. pmid:15456746
Jori FP et al. RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells. 2005 Cell Death Differ. pmid:15459751
Nan X et al. Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA. 2004 Biochem. Biophys. Res. Commun. pmid:15465025
Lee HS et al. Gene expression analysis in human gastric cancer cell line treated with trichostatin A and S-adenosyl-L-homocysteine using cDNA microarray. 2004 Biol. Pharm. Bull. pmid:15467184
Sangster-Guity N et al. Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment. 2004 Cancer Biol. Ther. pmid:15467438
Vaquero A et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. 2004 Mol. Cell pmid:15469825
Ladd PD et al. Identification of a genomic fragment that directs hematopoietic-specific expression of Rac2 and analysis of the DNA methylation profile of the gene locus. 2004 Gene pmid:15474314
Li H and Wu X Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. 2004 Biochem. Biophys. Res. Commun. pmid:15474507
Spenger A et al. Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. 2004 Protein Expr. Purif. pmid:15477077
Alcendor RR et al. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. 2004 Circ. Res. pmid:15486319
Gius D et al. Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. 2004 Cancer Cell pmid:15488759
Alikhani-Koopaei R et al. Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. 2004 J. Clin. Invest. pmid:15489962
Yee SB et al. Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. 2004 Int. J. Oncol. pmid:15492835
Emmans VC et al. Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. 2004 Biochem. Soc. Trans. pmid:15494029
Spengler ML et al. Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism. 2005 Cell. Signal. pmid:15494207
Canes D et al. Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. 2005 Int. J. Cancer pmid:15499627
De La Fuente R et al. Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. 2004 Dev. Biol. pmid:15501230
Lin AC et al. The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. 2004 J. Biol. Chem. pmid:15507435
Chang S and Pikaard CS Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. 2005 J. Biol. Chem. pmid:15516340
Wang S and Zhu J The hTERT gene is embedded in a nuclease-resistant chromatin domain. 2004 J. Biol. Chem. pmid:15516693
El-Khoury V et al. Effects of the histone deacetylase inhibitor trichostatin A on nuclear texture and c-jun gene expression in drug-sensitive and drug-resistant human H69 lung carcinoma cells. 2004 Cytometry A pmid:15517561
Kawano T et al. Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect. 2004 Sep-Oct Anticancer Res. pmid:15517875
Hammond SM et al. Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia. 2005 Leuk. Res. pmid:15541480
Ramakrishnan G et al. Histone acetyltransferases and deacetylase in Entamoeba histolytica. 2004 Mol. Biochem. Parasitol. pmid:15555732