trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Ganglioneuroma D005729 2 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Chromosome Inversion D007446 1 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Bence M et al. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. 2012 J Neural Transm pmid:21785940
Suh HS et al. Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. 2010 J Neuroimmune Pharmacol pmid:20157787
Fleiss B et al. Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. 2012 J Neuroinflammation pmid:22512781
Noro R et al. The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application. 2009 J Nippon Med Sch pmid:19305113
Por ED et al. Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. 2016 J Ocul Pharmacol Ther pmid:27494828
Sun G et al. Insights into the lysine acetylproteome of human sperm. 2014 J Proteomics pmid:25038526
Gavin DP et al. Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. 2009 J Psychiatr Res pmid:19187942
Gavin DP et al. Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. 2009 J Psychiatry Neurosci pmid:19448855
Albertus DL et al. AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. 2008 J Thorac Oncol pmid:18978557
Seo SK et al. Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. 2011 J Thorac Oncol pmid:21642861
Selinger CI et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. 2011 J Thorac Oncol pmid:21597389
Kakihana M et al. Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition. 2009 J Thorac Oncol pmid:20009910
Kimura T et al. Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. 2011 J Toxicol Sci pmid:21467744
Simões-Pires CA et al. Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. 2017 J Vis Exp pmid:28829415
Azuma R et al. Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer. 2018 J Vis Exp pmid:29757287
Valapour M et al. Histone deacetylation inhibits IL4 gene expression in T cells. 2002 J. Allergy Clin. Immunol. pmid:11842291
Su RC et al. Epigenetic regulation of established human type 1 versus type 2 cytokine responses. 2008 J. Allergy Clin. Immunol. pmid:17980413
Milagre I et al. Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. 2010 J. Alzheimers Dis. pmid:20930312
Kudo K et al. Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. 2017 J. Am. Chem. Soc. pmid:28497964
Ren C et al. Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors. 2005 J. Am. Soc. Mass Spectrom. pmid:16099169
Yoshikawa M et al. Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. 2007 J. Am. Soc. Nephrol. pmid:17135397
Yu Z et al. Histone deacetylases augment cytokine induction of the iNOS gene. 2002 J. Am. Soc. Nephrol. pmid:12138131
Hou W et al. Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. 2012 Nov-Dec J. Androl. pmid:22556385
Fenic I et al. In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. 2008 Mar-Apr J. Androl. pmid:18046049
Fenic I et al. In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. 2004 Sep-Oct J. Androl. pmid:15292114
Shi LH et al. Trichostatin A and nuclear reprogramming of cloned rabbit embryos. 2008 J. Anim. Sci. pmid:18245503
Ueda JY et al. JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. 2009 J. Antibiot. pmid:19300468
Yoshida M et al. Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells. 1990 J. Antibiot. pmid:2211374
Otoguro K et al. Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of trichostatin A. 1988 J. Antibiot. pmid:3372352
Takahashi I et al. Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase. 1996 J. Antibiot. pmid:8682722
Komatsu Y and Hayashi H Histone deacetylase inhibitors up-regulate the expression of cell surface MHC class-I molecules in B16/BL6 cells. 1998 J. Antibiot. pmid:9531994
Koguchi Y et al. Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor. 1997 J. Antibiot. pmid:9592573
Kim YB et al. Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. 2000 J. Antibiot. pmid:11132966
Dupré-Aucouturier S et al. Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. 2015 J. Appl. Physiol. pmid:26112243
Jafari S et al. Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos. 2011 J. Assist. Reprod. Genet. pmid:22020531
Slattery EL et al. Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. 2009 J. Assoc. Res. Otolaryngol. pmid:19340485
Azechi T et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. 2013 J. Atheroscler. Thromb. pmid:23518467
Okamoto H et al. Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). 2006 J. Atheroscler. Thromb. pmid:16908950
Reilly CM et al. The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. 2008 J. Autoimmun. pmid:18650065
Hildmann C et al. A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. 2004 J. Bacteriol. pmid:15060035
Maruoka H et al. Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons. 2011 J. Biochem. pmid:21908547
Yamamoto I et al. Histone hyperacetylation plays a role in augmentation of IL-4-induced IgE production in LPS-stimulated murine B-lymphocytes by sodium butyrate. 1996 J. Biochem. pmid:8827437
Zhao W et al. The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. 2005 J. Biochem. pmid:15809347
Kook SH et al. Epstein-Barr virus-infected Akata cells are sensitive to histone deacetylase inhibitor TSA-provoked apoptosis. 2005 J. Biochem. Mol. Biol. pmid:16336792
Zhang Y and Zhang B Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. 2016 J. Biochem. Mol. Toxicol. pmid:26509796
Jin B and Ryu DY Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes. 2004 J. Biochem. Mol. Toxicol. pmid:15252868
Henderson C et al. Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). 2003 J. Biol. Chem. pmid:12556448
Sanyal S et al. Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. 2002 J. Biol. Chem. pmid:11705994
Yang J et al. A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. 2010 J. Biol. Chem. pmid:20630860
Kurschat P et al. Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. 2006 J. Biol. Chem. pmid:16330548
Topark-Ngarm A et al. CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. 2006 J. Biol. Chem. pmid:16950772
Kurtev V et al. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. 2004 J. Biol. Chem. pmid:15140878
Roy S and Tenniswood M Site-specific acetylation of p53 directs selective transcription complex assembly. 2007 J. Biol. Chem. pmid:17121856
Musikacharoen T et al. Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. 2003 J. Biol. Chem. pmid:12511574
Gusterson RJ et al. The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. 2003 J. Biol. Chem. pmid:12477714
Phiel CJ et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. 2001 J. Biol. Chem. pmid:11473107
Dai X et al. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor. 2010 J. Biol. Chem. pmid:20566633
Leu TH et al. Participation of p97Eps8 in Src-mediated transformation. 2004 J. Biol. Chem. pmid:14699156
Pagans S et al. Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. 2004 J. Biol. Chem. pmid:14701830
Hwang CK et al. Transcriptional regulation of mouse mu opioid receptor gene by PU.1. 2004 J. Biol. Chem. pmid:14998994
Brush MH et al. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 2004 J. Biol. Chem. pmid:14670976
Qiao Y et al. Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. 2015 J. Biol. Chem. pmid:25519907
Hattori N et al. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. 2004 J. Biol. Chem. pmid:14761969
Horion J et al. Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha. 2007 J. Biol. Chem. pmid:17409387
Ginjala V et al. Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. 2002 J. Biol. Chem. pmid:11777900
Massillon D et al. Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. 2003 J. Biol. Chem. pmid:12915406
Cabral AL et al. Regulation of the cellular prion protein gene expression depends on chromatin conformation. 2002 J. Biol. Chem. pmid:11739375
Park SH et al. Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. 2002 J. Biol. Chem. pmid:11744689
Shan J et al. ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. 2012 J. Biol. Chem. pmid:22955275
Sarg B et al. Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation. 2004 J. Biol. Chem. pmid:15456746
Mogal AP et al. Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation. 2007 J. Biol. Chem. pmid:17602165
Wong CY et al. Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. 2011 J. Biol. Chem. pmid:21636851
Carmen AA et al. HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. 1996 J. Biol. Chem. pmid:8663039
Chen CS et al. Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. 2005 J. Biol. Chem. pmid:16186112
Ventura A et al. The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. 2002 J. Biol. Chem. pmid:11948181
Kang J et al. Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. 2000 J. Biol. Chem. pmid:10913161
Ohoka N et al. Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. 2007 J. Biol. Chem. pmid:17872950
Tong X et al. Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. 2005 J. Biol. Chem. pmid:15713675
Gan Y et al. Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. 2005 J. Biol. Chem. pmid:15722551
McCool KW et al. The role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation. 2007 J. Biol. Chem. pmid:17204470
Wen J et al. Tal1/SCL binding to pericentromeric DNA represses transcription. 2005 J. Biol. Chem. pmid:15677454
Kim Y et al. Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. 2012 J. Biol. Chem. pmid:22679019
Kijima M et al. Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. 1993 J. Biol. Chem. pmid:8226751
Zhang Y and Dufau ML Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. 2002 J. Biol. Chem. pmid:12091390
Lin HM et al. Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. 2002 J. Biol. Chem. pmid:12048199
Gong XQ and Li L Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. 2002 J. Biol. Chem. pmid:11809751
Tominaga K et al. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. 2003 J. Biol. Chem. pmid:14506250
Schuetz A et al. Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. 2008 J. Biol. Chem. pmid:18285338
Zhang Y et al. Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release. 2008 J. Biol. Chem. pmid:18596044
Wagner S et al. SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. 2006 J. Biol. Chem. pmid:16861234
Hayakawa K et al. Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. 2013 J. Biol. Chem. pmid:23625921
Hayakawa F et al. Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis. 2008 J. Biol. Chem. pmid:18621739
Fass DM et al. Deacetylase activity is required for cAMP activation of a subset of CREB target genes. 2003 J. Biol. Chem. pmid:12939274
Zhao C et al. A composite motif of the Drosophila morphogenetic protein bicoid critical to transcription control. 2003 J. Biol. Chem. pmid:12939280
Hinoi T et al. Silencing of CDX2 expression in colon cancer via a dominant repression pathway. 2003 J. Biol. Chem. pmid:12947088
Levenson JM et al. Regulation of histone acetylation during memory formation in the hippocampus. 2004 J. Biol. Chem. pmid:15273246
Walia H et al. Histone acetylation is required to maintain the unfolded nucleosome structure associated with transcribing DNA. 1998 J. Biol. Chem. pmid:9603965
Banchio C et al. Role of histone deacetylase in the expression of CTP:phosphocholine cytidylyltransferase alpha. 2006 J. Biol. Chem. pmid:16484221
Arora T et al. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. 2003 J. Biol. Chem. pmid:12716907
Theisen JW et al. Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. 2013 J. Biol. Chem. pmid:23349465