trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Nerve Degeneration D009410 53 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Mukhopadhyay NK et al. Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. 2006 Ann. Thorac. Surg. pmid:16488717
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Nishiyama A et al. Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. 2006 Mol. Biol. Cell pmid:16339075
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Morinobu A et al. Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. 2006 J. Rheumatol. pmid:16755652
Son YO et al. Involvement of caspase activation and mitochondrial stress in trichostatin A-induced apoptosis of Burkitt's lymphoma cell line, Akata. 2006 J. Cell. Biochem. pmid:16817225
Lau QC et al. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. 2006 Cancer Res. pmid:16818622
Yamada N et al. MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. 2006 Int. J. Cancer pmid:16721789
Kim Y et al. Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. 2006 J. Steroid Biochem. Mol. Biol. pmid:16723222
Santander VS et al. Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. 2006 Mol. Cell. Biochem. pmid:16733802
Kong Y et al. Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. 2006 Circulation pmid:16735673
Dannenberg LO et al. Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. 2006 Alcohol. Clin. Exp. Res. pmid:16737450
Cabrero JR et al. Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. 2006 Mol. Biol. Cell pmid:16738306
Vulcano F et al. HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. 2006 Exp. Cell Res. pmid:16739251
Qi H and Ratnam M Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. 2006 Cancer Res. pmid:16740727
Nusinzon I and Horvath CM Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. 2006 Mol. Cell. Biol. pmid:16581785
Ibanez de Caceres I et al. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. 2006 Cancer Res. pmid:16707423
Imre G et al. Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. 2006 Cancer Res. pmid:16707469
Jaalouk DE et al. Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. 2006 Virol. J. pmid:16603064
Kim MY et al. Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. 2006 Mol. Endocrinol. pmid:16497729
Leng Y and Chuang DM Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. 2006 J. Neurosci. pmid:16837598
Scott SA et al. 5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. 2006 Leuk. Res. pmid:16043219
Hofmann A et al. Epigenetic regulation of lentiviral transgene vectors in a large animal model. 2006 Mol. Ther. pmid:16140581
Aung HT et al. LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. 2006 FASEB J. pmid:16816106
Clem BF and Clark BJ Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. 2006 Mol. Endocrinol. pmid:16109738
Mai A et al. Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. 2006 J. Med. Chem. pmid:17004718
Yao J et al. NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. 2006 Pharmacol. Res. pmid:17005413
Inoue K et al. Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:17008592
Baqir S and Smith LC Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. 2006 Cloning Stem Cells pmid:17009896
Hong ZY et al. [Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. 2006 Ai Zheng pmid:16965673
Banwell CM et al. Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. 2006 Clin. Cancer Res. pmid:16609009
Jung JW et al. Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. 2006 Cancer Lett. pmid:16337085
Tyson-Capper AJ et al. Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. 2006 Mol. Hum. Reprod. pmid:16959971
Chen J et al. Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells. 2006 Pharmazie pmid:16964716
Kim MY et al. A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16924111
Mühlethaler-Mottet A et al. Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. 2006 BMC Cancer pmid:16930472
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Kimura N et al. Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. 2006 Protist pmid:16839811
Monte M et al. MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16847267
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Dokras A et al. Epigenetic regulation of maspin expression in the human placenta. 2006 Mol. Hum. Reprod. pmid:16936308
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Gialitakis M et al. Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. 2006 Nucleic Acids Res. pmid:16452299
Kwon HS et al. Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. 2006 Mar-Apr Biochim. Biophys. Acta pmid:16757381
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Kim HJ et al. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. 2007 J. Pharmacol. Exp. Ther. pmid:17371805
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Wong CM et al. Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. 2007 Hepatology pmid:17464989
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Berg T et al. Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. 2007 Leuk. Res. pmid:17056112
Sato N et al. RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. 2007 Int. J. Cancer pmid:17096327
Wu Y et al. The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. 2007 Genes Cells pmid:17663720
Schneider G et al. HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. 2007 Cell Prolif. pmid:17635519
Bode KA et al. Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. 2007 Immunology pmid:17635610
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Park JJ et al. Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. 2007 J. Gen. Virol. pmid:18024889
Moiseeva EP et al. Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. 2007 Mol. Cancer Ther. pmid:18025290
Mazzarelli P et al. Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? 2007 Cancer Biol. Ther. pmid:18253084
Feng W et al. Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. 2007 Int. J. Cancer pmid:17230502
Karam JA et al. The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. 2007 Int. J. Cancer pmid:17230511
Ghosh AK et al. Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. 2007 Biochem. Biophys. Res. Commun. pmid:17234156
Wang F et al. Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos. 2007 Biol. Reprod. pmid:17823087
De los Santos M et al. Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. 2007 Mol. Cancer Ther. pmid:17431121
Qi J et al. [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. 2007 Zhonghua Zhong Liu Za Zhi pmid:18396643
Qi J et al. [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. 2007 Zhonghua Yi Xue Za Zhi pmid:17923031
Pulukuri SM et al. Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. 2007 J. Biol. Chem. pmid:17923479