| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Radiation Injuries | D011832 | 14 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Enteritis | D004751 | 8 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Fetal Growth Retardation | D005317 | 9 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meschini R et al. | Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. | 2015 | Mutat. Res. | pmid:25942615 |
| Ooi JY et al. | HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. | 2015 | Epigenetics | pmid:25941940 |
| Marquardt JU et al. | Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. | 2015 | J. Hepatol. | pmid:25937435 |
| Meng J et al. | Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. | 2015 | Mol Med Rep | pmid:25695595 |
| Wang P et al. | Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays. | 2015 | Plant Cell Physiol. | pmid:25670712 |
| Hao ZF et al. | Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells. | 2015 | Tumour Biol. | pmid:25371069 |
| Nakada Y et al. | Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells. | 2015 | Endocr. J. | pmid:26497760 |
| Cabanel M et al. | Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. | 2015 | PLoS ONE | pmid:26196676 |
| Suo H et al. | NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. | 2015 | Neuropharmacology | pmid:26188143 |
| Gutiérrez J et al. | Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. | 2015 | Mol. Cell. Biochem. | pmid:26173416 |
| Xie M et al. | Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:25352747 |
| Xiong J et al. | USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. | 2014 | Mol Med Rep | pmid:25323692 |
| Ishihara K | Eosinophil cell lines. | 2014 | Methods Mol. Biol. | pmid:24986606 |
| Lee J et al. | Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS). | 2014 | Curr. Med. Chem. | pmid:25005187 |
| He G et al. | Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. | 2014 | Tumour Biol. | pmid:24122231 |
| Tu CY et al. | Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. | 2014 | Biomed Res Int | pmid:24707474 |
| Zou JY and Crews FT | Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. | 2014 | PLoS ONE | pmid:24551070 |
| Guilluy C et al. | Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. | 2014 | Nat. Cell Biol. | pmid:24609268 |
| Serrat N et al. | The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ. | 2014 | J. Immunol. | pmid:24307736 |
| Hou SY et al. | Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. | 2014 | Arch. Med. Res. | pmid:24316396 |