| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhou Q et al. | TGFbeta mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylation. | 2010 | J. Cell. Physiol. | pmid:20232294 |
| Chen WP et al. | Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. | 2010 | Mol. Biol. Rep. | pmid:20237852 |
| Yoshikawa M et al. | Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. | 2010 | Eur. J. Pharmacol. | pmid:20553909 |
| Mousa SA et al. | Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. | 2010 | Cancer Lett. | pmid:19733430 |
| Russell SB et al. | Epigenetically altered wound healing in keloid fibroblasts. | 2010 | J. Invest. Dermatol. | pmid:20555348 |
| Repouskou A et al. | The circadian expression of c-MYC is modulated by the histone deacetylase inhibitor trichostatin A in synchronized murine neuroblastoma cells. | 2010 | Chronobiol. Int. | pmid:20560708 |
| Swingler TE et al. | MMP28 gene expression is regulated by Sp1 transcription factor acetylation. | 2010 | Biochem. J. | pmid:20144149 |
| Liu Z et al. | Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801101 |
| Liu TY et al. | EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis. | 2010 | Mol. Cancer | pmid:20144199 |
| Nam HJ et al. | Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. | 2010 | J. Biol. Chem. | pmid:20696758 |
| Awe S and Renkawitz-Pohl R | Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster. | 2010 | Syst Biol Reprod Med | pmid:20170286 |
| Jichan Nie SW et al. | Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent. | 2010 | Reprod Sci | pmid:20697142 |
| Akiba Y et al. | Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20170631 |
| Costa-Borges N et al. | Comparison between the effects of valproic acid and trichostatin A on the in vitro development, blastocyst quality, and full-term development of mouse somatic cell nuclear transfer embryos. | 2010 | Cell Reprogram | pmid:20698782 |
| Islam NM et al. | Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20045316 |
| Benny Klimek ME et al. | Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20036643 |
| Peng CY et al. | Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines. | 2010 | Leuk. Lymphoma | pmid:20038232 |
| Lei L et al. | Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells. | 2010 | Chin. Med. Sci. J. | pmid:21232178 |
| Obier N et al. | Inhibition of histone deacetylases by Trichostatin A leads to a HoxB4-independent increase of hematopoietic progenitor/stem cell frequencies as a result of selective survival. | 2010 | Cytotherapy | pmid:20210674 |
| Krishnan M et al. | HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. | 2010 | Oncogene | pmid:19881542 |
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| Ikeda S et al. | Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts. | 2009 | Zygote | pmid:19356267 |
| Morita K et al. | Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. | 2009 | J. Neurosci. Res. | pmid:19360904 |
| von Burstin J et al. | E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. | 2009 | Gastroenterology | pmid:19362090 |
| Yang X et al. | CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. | 2009 | PLoS ONE | pmid:19340297 |
| Slattery EL et al. | Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. | 2009 | J. Assoc. Res. Otolaryngol. | pmid:19340485 |
| Vilar E et al. | Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. | 2009 | Clin. Cancer Res. | pmid:19351759 |
| Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
| Bennett KL et al. | AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. | 2009 | PLoS ONE | pmid:19742317 |
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| Dombrowsky H et al. | Conserved responses to trichostatin A in rodent lungs exposed to endotoxin or stretch. | 2009 | Pulm Pharmacol Ther | pmid:19744573 |
| Dandrea M et al. | MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. | 2009 | Nucleic Acids Res. | pmid:19745053 |
| Lugrin J et al. | Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. | 2009 | Biochim. Biophys. Acta | pmid:19747950 |
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| Diplas AI et al. | Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. | 2009 | Nucleic Acids Res. | pmid:19767614 |
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| Chen FQ et al. | Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea. | 2009 | J. Neurochem. | pmid:19141081 |
| Zhao W et al. | Histone deacetylase inhibitor, trichostatin A, affects gene expression patterns during morphogenesis of chicken limb buds in vivo. | 2009 | Cells Tissues Organs (Print) | pmid:19147985 |
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| Gavin DP et al. | Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. | 2009 | J Psychiatry Neurosci | pmid:19448855 |
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