Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wallace DM and Cotter TG | Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina. | 2009 | J. Neurosci. Res. | pmid:18951482 |
Li M et al. | Upregulation of human with-no-lysine kinase-4 gene expression by GATA-1 acetylation. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18793746 |
Wang X et al. | Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes. | 2009 | Growth Factors | pmid:19107653 |
Cao Y et al. | Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19966229 |
Trunzer M et al. | Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation. | 2009 | J. Med. Chem. | pmid:19108654 |
Wang XX and Fu L | [Recent advances in DNA demethylation in tumor therapy]. | 2009 | Zhonghua Bing Li Xue Za Zhi | pmid:19575888 |
Sawarkar R et al. | Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum. | 2009 | J. Mol. Biol. | pmid:19576222 |
Hirose N et al. | ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19422799 |
Park SJ et al. | Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. | 2009 | Biochem. Pharmacol. | pmid:19426671 |
Piotrowska H and Jagodzinski PP | Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. | 2009 | Arch. Med. Res. | pmid:19427965 |
Kakihana M et al. | Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition. | 2009 | J Thorac Oncol | pmid:20009910 |
O'Leary DA et al. | Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. | 2009 | PLoS ONE | pmid:20020055 |
Lu MC et al. | Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. | 2009 | Arch. Toxicol. | pmid:18709356 |
Hoebeeck J et al. | Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. | 2009 | Cancer Lett. | pmid:18819746 |
Susick L et al. | Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. | 2008 Sep-Oct | J. Cell. Mol. Med. | pmid:18053091 |
Li X and Bai XZ | [NF-kappaB modulates activation of the BMP-2 gene by trichostatin A]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140318 |
Kir'ianov GI et al. | [Nucleosome positioning within neomycinphosphotransferase gene (NPTII) on yeast plasmid in repressed and active state]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140324 |
Miyoshi M et al. | Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells. | 2008 Nov-Dec | Nutrition | pmid:18723323 |
Nishikiori N et al. | Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9. | 2008 May-Jun | Jpn. J. Ophthalmol. | pmid:18661270 |
Fenic I et al. | In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. | 2008 Mar-Apr | J. Androl. | pmid:18046049 |
Smetana K et al. | To the nucleolar density and size in apoptotic human leukemic myeloblasts produced in vitro by Trichostatin A. | 2008 Jul-Sep | Eur J Histochem | pmid:18840553 |
Kovács P and Csaba G | The effect of histone deacetylase inhibitor trichostatin A (TSA) on the incorporation of 32P (Pi) and 3H-palmitic acid into the phospholipids of Tetrahymena. | 2008 Jan-Feb | Cell Biochem. Funct. | pmid:17191269 |
Björkman M et al. | Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. | 2008 | Int. J. Cancer | pmid:18798265 |
Oger F et al. | The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18977200 |
Albertus DL et al. | AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. | 2008 | J Thorac Oncol | pmid:18978557 |
Hayashi K et al. | Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. | 2008 | Cell Stem Cell | pmid:18940731 |
Ridolfi E et al. | Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. | 2008 | Br. J. Cancer | pmid:18941460 |
Cao W et al. | Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. | 2008 | J. Exp. Med. | pmid:18504304 |
Bigl M et al. | Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18938139 |
Golyshev SA et al. | [The role of DNA methylation and histone modifications in structural maintainance of heterochromatin domains (chromocenters)]. | 2008 | Tsitologiia | pmid:19140344 |
Zhang S et al. | Effect of trichostatin a on viability and microRNA expression in human pancreatic cancer cell line BxPC-3. | 2008 | Exp. Oncol. | pmid:19112422 |
Kim TY et al. | Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. | 2008 | Exp. Mol. Med. | pmid:19116449 |
Jiang SJ et al. | [Effects of trichostatin A and paclitaxel on apoptosis and microtubule stabilization in endometrial carcinoma cells: an in vitro research]. | 2008 | Zhonghua Yi Xue Za Zhi | pmid:19087722 |
Khan AN et al. | Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. | 2008 | Cancer Immunol. Immunother. | pmid:18046553 |
Domingo-Domènech J et al. | Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. | 2008 | Breast Cancer Res. Treat. | pmid:18064564 |
Hajji N et al. | Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. | 2008 | Oncogene | pmid:18071312 |
Heller G et al. | Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells. | 2008 | Cancer Res. | pmid:18172295 |
Yildirim F et al. | Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. | 2008 | Exp. Neurol. | pmid:18234195 |
Tang Y et al. | Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. | 2008 | Circ. Res. | pmid:18239137 |
Wang Q et al. | The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis. | 2008 | Cell Cycle | pmid:18239470 |
Li X et al. | The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. | 2008 | Cloning Stem Cells | pmid:18241125 |
Chou SD and Tomasi TB | Spatial distribution of histone methylation during MHC class II expression. | 2008 | Mol. Immunol. | pmid:17850872 |
Ragno R et al. | Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies. | 2008 | Eur J Med Chem | pmid:17698257 |
Dong G et al. | Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18310471 |
Kim M et al. | Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. | 2008 | Mol. Cancer Res. | pmid:18314483 |
Schuetz A et al. | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. | 2008 | J. Biol. Chem. | pmid:18285338 |
Horswill MA et al. | Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts. | 2008 | Exp. Eye Res. | pmid:18291368 |
Countryman JK et al. | Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors. | 2008 | J. Virol. | pmid:18337569 |
Makki MS et al. | TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. | 2008 | Nucleic Acids Res. | pmid:18535006 |
Borghol N et al. | Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes. | 2008 | Genomics | pmid:18343090 |
Hoffmann K et al. | Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases? | 2008 | Epilepsy Res. | pmid:18538545 |
Lin W et al. | Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. | 2008 | Genes Cells | pmid:18298800 |
Jiang X et al. | DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. | 2008 | Cancer Cell | pmid:18538736 |
Fan J et al. | ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:18264725 |
Gavin DP et al. | Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. | 2008 | Schizophr. Res. | pmid:18539439 |
Shi LH et al. | Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. | 2008 | Dev. Dyn. | pmid:18265023 |
Lecona E et al. | Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase. | 2008 | Mol. Cell. Biol. | pmid:18541673 |
Sasaki K et al. | Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera. | 2008 | Cancer Sci. | pmid:18271940 |
Moynihan AT et al. | Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility. | 2008 | Am. J. Obstet. Gynecol. | pmid:18455134 |
Brown CR et al. | Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. | 2008 | Genes Dev. | pmid:18316479 |
Mackay CL et al. | Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4. | 2008 | Anal. Chem. | pmid:18457408 |
Fleury L et al. | Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. | 2008 | Oncogene | pmid:18317449 |
Muscolini M et al. | Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18566213 |
Fantini D et al. | APE1/Ref-1 regulates PTEN expression mediated by Egr-1. | 2008 | Free Radic. Res. | pmid:18324520 |
Bieliauskas AV and Pflum MK | Isoform-selective histone deacetylase inhibitors. | 2008 | Chem Soc Rev | pmid:18568166 |
Zhang Y et al. | Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release. | 2008 | J. Biol. Chem. | pmid:18596044 |
Xu LN et al. | Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines. | 2008 | World J. Gastroenterol. | pmid:18442209 |
Yu C et al. | Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. | 2008 | Neuro-oncology | pmid:18445700 |
Habold C et al. | Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. | 2008 | J. Cell. Mol. Med. | pmid:18419600 |
Romieu P et al. | Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats. | 2008 | J. Neurosci. | pmid:18799668 |
Chan DW et al. | Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells. | 2008 | Int. J. Cancer | pmid:18553387 |
Roy S et al. | Histone deacetylase 5 represses the transcription of cyclin D3. | 2008 | J. Cell. Biochem. | pmid:18404677 |
Kawamoto K et al. | DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines. | 2008 | Int. J. Cancer | pmid:18404682 |
Kaipparettu BA et al. | Estrogen-mediated downregulation of CD24 in breast cancer cells. | 2008 | Int. J. Cancer | pmid:18404683 |
Jeseta M et al. | In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A. | 2008 | Zygote | pmid:18405435 |
Lin YC et al. | Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. | 2008 | Cancer Res. | pmid:18381445 |
Tischler JL et al. | Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors. | 2008 | J Enzyme Inhib Med Chem | pmid:18608778 |
Pandey SC et al. | Brain chromatin remodeling: a novel mechanism of alcoholism. | 2008 | J. Neurosci. | pmid:18385331 |
Chu F et al. | Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway. | 2008 | Aging Cell | pmid:18489729 |
Rebbaa A et al. | Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent. | 2008 | Angiogenesis | pmid:18386142 |
Wu JY et al. | Enhancement of glutamate uptake in 1-methyl-4-phenylpyridinium-treated astrocytes by trichostatin A. | 2008 | Neuroreport | pmid:18628666 |
Henkens T et al. | Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes. | 2008 | Toxicol. Lett. | pmid:18358644 |
Shakèd M et al. | Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling. | 2008 | PLoS ONE | pmid:18628975 |
Wei Q et al. | [Effect of trichostatin A on proliferation and interleukin-2 expression of mouse T cells in mixed lymphocyte culture]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18359716 |
Hämäläinen M et al. | Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors. | 2008 | Pulm Pharmacol Ther | pmid:17913526 |
Svechnikova I et al. | HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. | 2008 | Int. J. Oncol. | pmid:18360709 |
Fontán-Lozano A et al. | Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice. | 2008 | Mol. Cell. Neurosci. | pmid:18638560 |
Mukherjee P et al. | Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. | 2008 | Bioorg. Med. Chem. | pmid:18362073 |
Fabre C et al. | A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts. | 2008 | Cell Cycle | pmid:18641459 |
Brown SL et al. | Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. | 2008 | Radiat. Res. | pmid:18363436 |
Kozikowski AP et al. | Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. | 2008 | J. Med. Chem. | pmid:18642892 |
Dow GS et al. | Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. | 2008 | Antimicrob. Agents Chemother. | pmid:18644969 |
Liu PY et al. | Modulation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa Cells. | 2008 | Mol. Cancer Res. | pmid:18644983 |
Roy S et al. | Array-based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18645003 |
Schauber J et al. | Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. | 2008 | J. Invest. Dermatol. | pmid:17943182 |
Chen J et al. | Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis. | 2008 | Chem. Biol. Interact. | pmid:17961528 |
Haumaitre C et al. | Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. | 2008 | Mol. Cell. Biol. | pmid:18710955 |
Kim M et al. | LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer. | 2008 | Cancer Res. | pmid:18757430 |
Ma Y et al. | Inhibition of protein deacetylation by trichostatin A impairs microtubule-kinetochore attachment. | 2008 | Cell. Mol. Life Sci. | pmid:18759129 |
Zhang Y et al. | Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. | 2008 | J. Immunol. | pmid:18097041 |