Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kim HJ et al. | Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371805 |
Kitamura H et al. | Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition. | 2007 | J. Urol. | pmid:17574613 |
Vecsey CG et al. | Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. | 2007 | J. Neurosci. | pmid:17553985 |
Pinnoji RC et al. | Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. | 2007 | Virol. J. | pmid:17555596 |
Khan Z et al. | HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. | 2007 | Exp. Cell Res. | pmid:17555745 |
Donadelli M et al. | Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. | 2007 | Biochim. Biophys. Acta | pmid:17555830 |
Cantor JP et al. | Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. | 2007 | Int. J. Cancer | pmid:17019711 |
Liu L and Clipstone NA | Prostaglandin F2alpha inhibits adipocyte differentiation via a G alpha q-calcium-calcineurin-dependent signaling pathway. | 2007 | J. Cell. Biochem. | pmid:16888802 |
Hellebrekers DM et al. | Identification of epigenetically silenced genes in tumor endothelial cells. | 2007 | Cancer Res. | pmid:17483324 |
Yi T et al. | Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis. | 2007 | Exp. Mol. Med. | pmid:17464183 |
Wong CM et al. | Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. | 2007 | Hepatology | pmid:17464989 |
Chen Y et al. | Homeobox gene HOP has a potential tumor suppressive activity in human lung cancer. | 2007 | Int. J. Cancer | pmid:17417779 |
Liu T et al. | Design and synthesis of a potent histone deacetylase inhibitor. | 2007 | J. Med. Chem. | pmid:17419603 |
Hwang CK et al. | Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. | 2007 | Mol. Cell. Biol. | pmid:17452465 |
Piotrowska H and Jagodzinski PP | Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. | 2007 | Biomed. Pharmacother. | pmid:17498915 |
Berg T et al. | Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. | 2007 | Leuk. Res. | pmid:17056112 |
Iliopoulos D et al. | Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. | 2007 | Ann. Rheum. Dis. | pmid:17502362 |
Sato N et al. | RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. | 2007 | Int. J. Cancer | pmid:17096327 |
Zhang R et al. | HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. | 2007 | Mol. Cell. Biol. | pmid:17101789 |
Schneider G et al. | HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. | 2007 | Cell Prolif. | pmid:17635519 |
Bode KA et al. | Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. | 2007 | Immunology | pmid:17635610 |
Imai N et al. | Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. | 2007 | Stem Cells | pmid:17641247 |
Dai B and Rasmussen TP | Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. | 2007 | Stem Cells | pmid:17641388 |
Kaida D et al. | Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. | 2007 | Nat. Chem. Biol. | pmid:17643111 |
Kotake Y et al. | Splicing factor SF3b as a target of the antitumor natural product pladienolide. | 2007 | Nat. Chem. Biol. | pmid:17643112 |
Kang JH et al. | Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. | 2007 | Exp. Mol. Med. | pmid:17603295 |
Park JJ et al. | Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. | 2007 | J. Gen. Virol. | pmid:18024889 |
Moiseeva EP et al. | Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. | 2007 | Mol. Cancer Ther. | pmid:18025290 |
Brest P et al. | Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. | 2007 | Cancer Res. | pmid:18056459 |
Sourlingas TG et al. | Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. | 2007 | Ann. N. Y. Acad. Sci. | pmid:18056955 |
Ehrenkaufer GM et al. | Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. | 2007 | BMC Genomics | pmid:17612405 |
Mazzarelli P et al. | Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? | 2007 | Cancer Biol. Ther. | pmid:18253084 |
Feng W et al. | Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. | 2007 | Int. J. Cancer | pmid:17230502 |
Wu ZQ et al. | Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. | 2007 | Chin. Med. J. | pmid:18167185 |
Karam JA et al. | The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. | 2007 | Int. J. Cancer | pmid:17230511 |
Ghosh AK et al. | Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17234156 |
Shimazu T et al. | Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. | 2007 | J. Biol. Chem. | pmid:17172643 |
Januchowski R and Jagodzinski PP | Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. | 2007 | Int. Immunopharmacol. | pmid:17178387 |
Cras A et al. | Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. | 2007 | Oncogene | pmid:17213810 |
Han S et al. | HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter region. | 2007 | Immunol. Lett. | pmid:17270283 |
De los Santos M et al. | Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. | 2007 | Mol. Cancer Ther. | pmid:17431121 |
Qi J et al. | [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18396643 |
Qi J et al. | [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17923031 |
Pulukuri SM et al. | Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. | 2007 | J. Biol. Chem. | pmid:17923479 |
Stapnes C et al. | Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. | 2007 | Int. J. Oncol. | pmid:17982680 |
Honda H et al. | Regulation of the CLDN3 gene in ovarian cancer cells. | 2007 | Cancer Biol. Ther. | pmid:17986852 |
Renthal W et al. | Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. | 2007 | Neuron | pmid:17988634 |
Carén H et al. | Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. | 2007 | Br. J. Cancer | pmid:17940511 |
Kuljaca S et al. | Enhancing the anti-angiogenic action of histone deacetylase inhibitors. | 2007 | Mol. Cancer | pmid:17958916 |
Wee G et al. | Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos. | 2007 | Reproduction | pmid:18042635 |
Kwon HS et al. | Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. | 2006 Mar-Apr | Biochim. Biophys. Acta | pmid:16757381 |
Majumder S et al. | Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. | 2006 | J. Cell. Biochem. | pmid:16329111 |
Kurschat P et al. | Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. | 2006 | J. Biol. Chem. | pmid:16330548 |
Suzuki M et al. | Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. | 2006 | Oncogene | pmid:16331260 |
Fan J et al. | [Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:17533736 |
de Boer J et al. | Inhibition of histone acetylation as a tool in bone tissue engineering. | 2006 | Tissue Eng. | pmid:17518660 |
Malone CS et al. | B29 gene silencing in pituitary cells is regulated by its 3' enhancer. | 2006 | J. Mol. Biol. | pmid:16920149 |
Herman D et al. | Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. | 2006 | Nat. Chem. Biol. | pmid:16921367 |
Takahashi K et al. | Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. | 2006 | Int. J. Oncol. | pmid:16391785 |
Topark-Ngarm A et al. | CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. | 2006 | J. Biol. Chem. | pmid:16950772 |
Li Y et al. | A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. | 2006 | Genes Dev. | pmid:16980585 |
Minetti GC et al. | Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. | 2006 | Nat. Med. | pmid:16980968 |
Ohnishi K | [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | 2006 | Rinsho Ketsueki | pmid:16986710 |
Yamamoto G et al. | Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. | 2006 | Virchows Arch. | pmid:16416296 |
Yang QC et al. | Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. | 2006 | J. Exp. Clin. Cancer Res. | pmid:17310851 |
D'Andrea M et al. | Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. | 2006 | J. Cell. Physiol. | pmid:16419034 |
Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
Hernandez M et al. | A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. | 2006 | Prostate | pmid:16652385 |
Uchida H et al. | Human endometrial cytodifferentiation by histone deacetylase inhibitors. | 2006 | Hum. Cell | pmid:16643606 |
Stefanovsky V and Moss T | Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count. | 2006 | Cell Cycle | pmid:16582637 |
Sharma D et al. | Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. | 2006 | Cancer Res. | pmid:16778215 |
Sato TA and Mitchell MD | Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234266 |
Wu Y and Guo SW | Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. | 2006 | Gynecol. Obstet. Invest. | pmid:16778450 |
Iacomino G et al. | Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line. | 2006 | J. Cell. Biochem. | pmid:16795040 |
Vanniasinkam T et al. | Trichostatin-A enhances adaptive immune responses to DNA vaccination. | 2006 | J. Clin. Virol. | pmid:16765083 |
Li GC et al. | Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. | 2006 | Int. J. Urol. | pmid:16771729 |
Zhou C et al. | Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. | 2006 | Int. J. Oncol. | pmid:16773209 |
Zampetaki A et al. | TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16814255 |
Sestáková B and Vachtenheim J | Distinct co-regulation of endogenous versus transfected MITF-dependent tyrosinase promoter. | 2006 | Folia Biol. (Praha) | pmid:17116288 |
Balasubramaniyan V et al. | Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells. | 2006 | Neuroscience | pmid:17084985 |
El-Zawahry A et al. | In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. | 2006 | Cancer Gene Ther. | pmid:16167063 |
Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
Kozłowska A and Jagodziński PP | Effect of Trichostatin A on CD4 surface density in peripheral blood T cells. | 2006 | Folia Histochem. Cytobiol. | pmid:17219719 |
He J et al. | Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219959 |
Liu H et al. | Trichostatin A regulates hGCN5 expression and cell cycle on Daudi cells in vitro. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219960 |
Sun C et al. | Anticancer activities of trichostatin A on maligant lymphoid cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219961 |
Kim HR et al. | Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway? | 2006 | Exp. Mol. Med. | pmid:17202837 |
Karvonen U et al. | Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. | 2006 | Exp. Cell Res. | pmid:16860317 |
Wagner S et al. | SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. | 2006 | J. Biol. Chem. | pmid:16861234 |
Zhang X et al. | Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. | 2006 | Oncol. Rep. | pmid:16865256 |
Villanueva R et al. | Histone deacetylase 3 represses HTLV-1 tax transcription. | 2006 | Oncol. Rep. | pmid:16865259 |
van den Boom J et al. | Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. | 2006 | Int. J. Cancer | pmid:16865689 |
Bai J et al. | Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904634 |
Alao JP et al. | Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:16504004 |
Ostapkowicz A et al. | Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. | 2006 | Mol. Cancer Ther. | pmid:16505096 |
Hellebrekers DM et al. | Angiostatic activity of DNA methyltransferase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:16505122 |
Kong X et al. | Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. | 2006 | Mol. Cell. Biol. | pmid:16507982 |
Araki H et al. | Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. | 2006 | Exp. Hematol. | pmid:16459182 |
Sonnemann J et al. | Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. | 2006 | Int. J. Oncol. | pmid:16465382 |
Pedram M et al. | Telomere position effect and silencing of transgenes near telomeres in the mouse. | 2006 | Mol. Cell. Biol. | pmid:16479005 |