Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Medugno L et al. | The Krüppel-like zinc-finger protein ZNF224 represses aldolase A gene transcription by interacting with the KAP-1 co-repressor protein. | 2005 | Gene | pmid:16150558 |
Lu Z et al. | E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. | 2006 | Oncogene | pmid:16158053 |
Hwang DY and Ismail-Beigi F | Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16162661 |
Osada H et al. | Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. | 2005 | Mol. Carcinog. | pmid:16163707 |
Rogier E et al. | A novel biological assay to detect the active form of TGF-beta in urine to monitor renal allograft rejection. | 2005 | Kidney Int. | pmid:16164666 |
Di-Poï N et al. | Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. | 2005 | J. Biol. Chem. | pmid:16166081 |
Chang CW et al. | Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. | 2005 | Mol. Cell. Biol. | pmid:16166624 |
El-Zawahry A et al. | In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. | 2006 | Cancer Gene Ther. | pmid:16167063 |
Johnson J et al. | Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid. | 2005 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:16171558 |
Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
Xu CR et al. | Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16176989 |
Yaneva M et al. | Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. | 2005 | Nucleic Acids Res. | pmid:16177181 |
Chen CS et al. | Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. | 2005 | J. Biol. Chem. | pmid:16186112 |
Mühlisch J et al. | Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. | 2006 | Oncogene | pmid:16186793 |
Menegola E et al. | Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity. | 2005 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:16193500 |
Liu AL et al. | [A new target of cancer therapy: advances in the study of histone deacetylase]. | 2005 | Yao Xue Xue Bao | pmid:16196262 |
Fang MZ et al. | Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. | 2005 | Clin. Cancer Res. | pmid:16203797 |
Chou SD et al. | Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. | 2005 | Int. Immunol. | pmid:16210330 |
Bai Y et al. | Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. | 2005 | J. Immunol. | pmid:16210620 |
Chen G et al. | [Enhancive effect of histone deacetylase inhibitor trichostatin a on transfection efficiency of adenovirus in ovarian carcinoma cell line A2780]. | 2005 | Ai Zheng | pmid:16219132 |
Francia G et al. | Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents. | 2005 | Mol. Cancer Ther. | pmid:16227397 |
Sato TA and Mitchell MD | Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234266 |
Kasper LH et al. | Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. | 2005 | EMBO J. | pmid:16237459 |
Krishnan M et al. | Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. | 2006 | FASEB J. | pmid:16246867 |
Place RF et al. | HDACs and the senescent phenotype of WI-38 cells. | 2005 | BMC Cell Biol. | pmid:16250917 |
Bártová E et al. | Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases. | 2005 | J. Cell. Sci. | pmid:16254244 |
Columbaro M et al. | Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. | 2005 | Cell. Mol. Life Sci. | pmid:16261260 |
Burlibaşa L and Gavrilă L | Molecular and ultrastructural studies of the sperm chromatin from Triturus cristatus. | 2005 | Zygote | pmid:16261764 |
Hazzalin CA and Mahadevan LC | Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. | 2005 | PLoS Biol. | pmid:16262446 |
Hohl M and Thiel G | Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. | 2005 | Eur. J. Neurosci. | pmid:16262660 |
Bernes S et al. | Epigenetic and classical activation of Entamoeba histolytica heat shock protein 100 (EHsp100) expression. | 2005 | FEBS Lett. | pmid:16263115 |
Peng C et al. | The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. | 2006 | J. Cell. Biochem. | pmid:16265664 |
Gao S et al. | CpG methylation of the PAI-1 gene 5'-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines. | 2005 | Thromb. Haemost. | pmid:16268485 |
Li XX et al. | Function of c-Fos-like and c-Jun-like proteins on trichostatin A-induced G2/M arrest in Physarum polycephalum. | 2005 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:16270156 |
Juranek SA et al. | snRNA and heterochromatin formation are involved in DNA excision during macronuclear development in stichotrichous ciliates. | 2005 | Eukaryotic Cell | pmid:16278460 |
Jüngel A et al. | Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. | 2006 | Ann. Rheum. Dis. | pmid:16284094 |
Lee JH et al. | Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1. | 2005 | J. Endocrinol. | pmid:16293776 |
Schroeder TM and Westendorf JJ | Histone deacetylase inhibitors promote osteoblast maturation. | 2005 | J. Bone Miner. Res. | pmid:16294278 |
Marengo E et al. | Use of Legendre moments for the fast comparison of two-dimensional polyacrylamide gel electrophoresis maps images. | 2005 | J Chromatogr A | pmid:16301071 |
Tai HH et al. | Dynamic histone acetylation of late embryonic genes during seed germination. | 2005 | Plant Mol. Biol. | pmid:16307366 |
Williams SA et al. | NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. | 2006 | EMBO J. | pmid:16319923 |
Chen J and Kang JH | Quercetin and trichostatin A cooperatively kill human leukemia cells. | 2005 | Pharmazie | pmid:16320950 |
Wei M et al. | BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. | 2005 | Cancer Res. | pmid:16322213 |
Marchion DC et al. | Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. | 2005 | Clin. Cancer Res. | pmid:16322310 |
Kishigami S et al. | Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. | 2006 | Dev. Biol. | pmid:16325170 |
Mogal A and Abdulkadir SA | Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. | 2006 | Mol. Cell. Probes | pmid:16326072 |
Majumder S et al. | Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. | 2006 | J. Cell. Biochem. | pmid:16329111 |
Kurschat P et al. | Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. | 2006 | J. Biol. Chem. | pmid:16330548 |
Suzuki M et al. | Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. | 2006 | Oncogene | pmid:16331260 |
Cecconi D et al. | Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335935 |