Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hsu YF et al. | MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. | 2011 | Biochim. Biophys. Acta | pmid:21911040 |
Li L et al. | Regulation of histone acetylation by NDRG2 in glioma cells. | 2012 | J. Neurooncol. | pmid:21912936 |
Jafarpour F et al. | Somatic cell-induced hyperacetylation, but not hypomethylation, positively and reversibly affects the efficiency of in vitro cloned blastocyst production in cattle. | 2011 | Cell Reprogram | pmid:21919704 |
Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
Chen S et al. | [Effect of trichostatin alone and combination with imatinb on the proliferation and apoptosis of the K562R cells]. | 2011 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:21937807 |
Jeon HG et al. | Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. | 2011 | J. Urol. | pmid:21944112 |
Yang G et al. | Trichostatin a promotes cardiomyocyte differentiation of rat mesenchymal stem cells after 5-azacytidine induction or during coculture with neonatal cardiomyocytes via a mechanism independent of histone deacetylase inhibition. | 2012 | Cell Transplant | pmid:21944777 |
Kadaja-Saarepuu L et al. | Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. | 2012 | Int. J. Oncol. | pmid:21947346 |
Ekici M et al. | Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: major regulatory role of REST and Sp1. | 2012 | J. Cell. Biochem. | pmid:21948504 |
Meester-Smoor MA et al. | The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. | 2011 | PLoS ONE | pmid:21949683 |
Gillespie J et al. | Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. | 2012 | Arthritis Rheum. | pmid:21952924 |
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Dehnugara T et al. | An in vitro, short-term culture method for mammalian haploid round spermatids amenable for molecular manipulation. | 2012 | Mol. Reprod. Dev. | pmid:21953649 |
Majumdar G et al. | Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. | 2011 | Physiol. Genomics | pmid:21954451 |
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Wang W et al. | The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. | 2012 | Nucleic Acids Res. | pmid:21967847 |
Lee TB et al. | Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline. | 2012 | Cell Biol. Toxicol. | pmid:21968610 |
Rhodes LV et al. | The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. | 2012 | Oncol. Rep. | pmid:21971930 |
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Deckmann K et al. | Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. | 2012 | Cell. Signal. | pmid:21983014 |
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Hutt DM et al. | Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. | 2011 | ACS Med Chem Lett | pmid:21984958 |
Londhe P et al. | CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells. | 2012 | Int. J. Cancer | pmid:21989738 |
Anh TD et al. | The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis in YD-10B oral squamous carcinoma cells. | 2012 | Oncol. Rep. | pmid:21993600 |
Aoyama K et al. | Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. | 2011 | Exp. Cell Res. | pmid:22001646 |
Hong X et al. | Heparanase expression is associated with histone modifications in glioblastoma. | 2012 | Int. J. Oncol. | pmid:22001963 |
He HM et al. | [The effects of a histone deacetylase (HDAC) inhibitor on endotoxin-induced endothelial cell injury]. | 2011 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22005560 |
Sasaki Y et al. | p53 negatively regulates the hepatoma growth factor HDGF. | 2011 | Cancer Res. | pmid:22006999 |
Zhang FQ et al. | Cell-cycle-dependent variations in the FTIR spectroscopy of HeLa cells treated with trichostatin A. | 2011 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:22007388 |
Hagiwara H et al. | Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22019851 |
Jafari S et al. | Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos. | 2011 | J. Assist. Reprod. Genet. | pmid:22020531 |
Tseng AS et al. | HDAC activity is required during Xenopus tail regeneration. | 2011 | PLoS ONE | pmid:22022609 |
Rosborough BR et al. | Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. | 2012 | J. Leukoc. Biol. | pmid:22028329 |
Halder SK et al. | Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. | 2011 | Neoplasia | pmid:22028617 |
Landreville S et al. | Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. | 2012 | Clin. Cancer Res. | pmid:22038994 |
Wang QS et al. | [Silence mechanism of WT1 gene in leukemic cell line U937]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22040952 |
Chen X et al. | Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents. | 2011 | Molecules | pmid:22048700 |
Kong QR et al. | [TSA improve transgenic porcine cloned embryo development and transgene expression]. | 2011 | Yi Chuan | pmid:22049689 |
Matoba S et al. | RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22065773 |
Shepard BD et al. | Lysine acetylation induced by chronic ethanol consumption impairs dynamin-mediated clathrin-coated vesicle release. | 2012 | Hepatology | pmid:22095875 |
Yoshida M et al. | Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells. | 1990 | J. Antibiot. | pmid:2211374 |
Thakur VS et al. | Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases. | 2012 | Carcinogenesis | pmid:22114073 |
Yoshida M et al. | Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. | 1990 | J. Biol. Chem. | pmid:2211619 |
Wang X et al. | Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. | 2013 | Mol. Carcinog. | pmid:22121107 |
Rossi LE et al. | Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. | 2012 | J. Leukoc. Biol. | pmid:22124136 |
Poplineau M et al. | Raman microspectroscopy detects epigenetic modifications in living Jurkat leukemic cells. | 2011 | Epigenomics | pmid:22126296 |
Pichugin A et al. | Ring-like distribution of constitutive heterochromatin in bovine senescent cells. | 2011 | PLoS ONE | pmid:22132080 |
Fu S et al. | Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. | 2011 | PLoS ONE | pmid:22132182 |
Yoshida A et al. | Aberrant spikelet and panicle1, encoding a TOPLESS-related transcriptional co-repressor, is involved in the regulation of meristem fate in rice. | 2012 | Plant J. | pmid:22136599 |
Shen T et al. | Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22138223 |
Massa S et al. | Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogues of trichostatin A. | 1990 | J. Med. Chem. | pmid:2213836 |
da Costa Prando E et al. | Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. | 2011 | Epigenetics | pmid:22139571 |
Hsu YF et al. | Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22155142 |
Bebenek IG et al. | CYP2S1 is negatively regulated by corticosteroids in human cell lines. | 2012 | Toxicol. Lett. | pmid:22155357 |
Sakuma Y et al. | WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. | 2012 | Lab. Invest. | pmid:22157722 |
Chang J et al. | Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. | 2012 | Br. J. Cancer | pmid:22158273 |
Calfa G et al. | HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. | 2012 | Hippocampus | pmid:22161912 |
Poljakova J et al. | Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. | 2011 | Neuro Endocrinol. Lett. | pmid:22167207 |
Williams PJ et al. | HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. | 2011 | Ann. N. Y. Acad. Sci. | pmid:22172035 |
Zhai FX et al. | RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22179198 |
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Francisco R et al. | Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | 2012 | Cancer Lett. | pmid:22186300 |
Horvat T et al. | Epigenetic modulation of the HeLa cell membrane N-glycome. | 2012 | Biochim. Biophys. Acta | pmid:22192783 |
Becker JR et al. | In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. | 2012 | Cardiovasc. Res. | pmid:22198505 |
Shen YC et al. | The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. | 2012 | Dev. Biol. | pmid:22210003 |
Zhang CZ et al. | Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma. | 2012 | Cell Cycle | pmid:22214764 |
Johansson AS et al. | Valproic acid phase shifts the rhythmic expression of Period2::Luciferase. | 2011 | J. Biol. Rhythms | pmid:22215612 |
Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
Ma P et al. | Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22223663 |
Wang B et al. | Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage. | 2012 | Free Radic. Biol. Med. | pmid:22226832 |
Barrasa JI et al. | Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. | 2012 | Biochim. Biophys. Acta | pmid:22227581 |
Wang C et al. | Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. | 2012 | Diabetes Metab. Res. Rev. | pmid:22228707 |
Cho JS et al. | Epigenetic regulation of myofibroblast differentiation and extracellular matrix production in nasal polyp-derived fibroblasts. | 2012 | Clin. Exp. Allergy | pmid:22239687 |
Kohda T et al. | Gene expression profile normalization in cloned mice by trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22257163 |
Drzewiecka H and Jagodzinski PP | Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22257695 |
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Börner C et al. | Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. | 2012 | Neuroimmunomodulation | pmid:22262103 |
Li Y et al. | Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. | 2012 | Cancer Lett. | pmid:22266186 |
Bajbouj K et al. | P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. | 2012 | J. Neurooncol. | pmid:22270849 |
Zhang L et al. | Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22271820 |
He D et al. | Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma. | 2012 | Eur. J. Cancer Prev. | pmid:22273848 |
Hosoya T et al. | Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. | 2012 | J. Nat. Prod. | pmid:22276693 |
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Estella C et al. | Inhibition of histone deacetylase activity in human endometrial stromal cells promotes extracellular matrix remodelling and limits embryo invasion. | 2012 | PLoS ONE | pmid:22291969 |
Chen J et al. | Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. | 2013 | Toxicol Ind Health | pmid:22294440 |
Banerjee A et al. | Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22298527 |
Kerr JB et al. | The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. | 2012 | Reproduction | pmid:22301887 |
Humphreys KJ et al. | Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. | 2013 | Mol. Carcinog. | pmid:22308110 |
Hirata Y et al. | Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22321215 |
Sawai K et al. | Epigenetic status and full-term development of bovine cloned embryos treated with trichostatin A. | 2012 | J. Reprod. Dev. | pmid:22322145 |
Li H et al. | Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. | 2012 | Diabetes | pmid:22338096 |
Duncan HF et al. | Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. | 2012 | J Endod | pmid:22341071 |
Ning SF et al. | Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2013 | Zygote | pmid:22355002 |
Chan JN et al. | Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. | 2012 | Mol. Cell Proteomics | pmid:22357554 |