trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jeon HG et al. | Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. | 2011 | J. Urol. | pmid:21944112 |
| Meester-Smoor MA et al. | The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. | 2011 | PLoS ONE | pmid:21949683 |
| Halder SK et al. | Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. | 2011 | Neoplasia | pmid:22028617 |
| Hutt DM et al. | Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. | 2011 | ACS Med Chem Lett | pmid:21984958 |
| Wang JP et al. | Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression. | 2011 | Differentiation | pmid:21074928 |
| Oyer JA et al. | Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation. | 2011 | Mutat. Res. | pmid:21035468 |
| Pabba C et al. | Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21109435 |
| Poljakova J et al. | Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. | 2011 | Neuro Endocrinol. Lett. | pmid:22167207 |
| Jugová A et al. | Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. | 2011 | Cell Biol. Int. | pmid:21635225 |
| Wong CY et al. | Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. | 2011 | J. Biol. Chem. | pmid:21636851 |
| Hayashi-Takanaka Y et al. | Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. | 2011 | Nucleic Acids Res. | pmid:21576221 |
| Bouquet F et al. | A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. | 2011 | J. Cell. Sci. | pmid:21576354 |
| Hawk JD et al. | Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. | 2011 | Learn. Mem. | pmid:21576516 |
| Dong X et al. | Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. | 2011 | Endocr. Relat. Cancer | pmid:21367844 |
| Zhu QY et al. | C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. | 2011 | Cell Death Dis | pmid:21368888 |
| Hsu YF et al. | p53 in trichostatin A induced C6 glioma cell death. | 2011 | Biochim. Biophys. Acta | pmid:21376104 |
| Ryhänen T et al. | Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells. | 2011 | J. Biomed. Biotechnol. | pmid:20981255 |
| Sun JY et al. | Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia. | 2011 | Clin Lymphoma Myeloma Leuk | pmid:21454220 |
| Min XJ et al. | Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21454376 |
| Belakavadi M et al. | Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. | 2011 | Mol. Cell. Endocrinol. | pmid:21458529 |
| Zelko IN et al. | Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21493784 |
| da Costa Prando E et al. | Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. | 2011 | Epigenetics | pmid:22139571 |
| Kretzner L et al. | Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. | 2011 | Cancer Res. | pmid:21502403 |
| Poplineau M et al. | Raman microspectroscopy detects epigenetic modifications in living Jurkat leukemic cells. | 2011 | Epigenomics | pmid:22126296 |
| Qiu GH et al. | Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. | 2011 | Mol. Ther. | pmid:21540836 |
| Kong Q et al. | Effect of trichostatin A and 5-Aza-2'-deoxycytidine on transgene reactivation and epigenetic modification in transgenic pig fibroblast cells. | 2011 | Mol. Cell. Biochem. | pmid:21541675 |
| Wang QS et al. | [Silence mechanism of WT1 gene in leukemic cell line U937]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22040952 |
| Park JW et al. | Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. | 2011 | J. Nat. Prod. | pmid:21504214 |
| Matoba S et al. | RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22065773 |
| Bolleyn J et al. | Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. | 2011 | Toxicol In Vitro | pmid:21513791 |
| Rajasingh J et al. | Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. | 2011 | PLoS ONE | pmid:21799893 |
| Klawitter M et al. | Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. | 2011 | J Negat Results Biomed | pmid:21801383 |
| Atanackovic D et al. | Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. | 2011 | Am. J. Hematol. | pmid:21898529 |
| Paterson S et al. | Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. | 2011 | Drug Metab. Dispos. | pmid:20870783 |
| Wang JP et al. | Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. | 2011 | PLoS ONE | pmid:21901157 |
| Nakaya Y et al. | Epigenetic regulation on the 5'-proximal CpG island of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B. | 2011 | Microbes Infect. | pmid:20951222 |
| Robers MB et al. | Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. | 2011 | Mol Biosyst | pmid:20931131 |
| Hsu YF et al. | MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. | 2011 | Biochim. Biophys. Acta | pmid:21911040 |
| Crandall JE et al. | Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. | 2011 | J. Neurochem. | pmid:21895658 |
| Jafarpour F et al. | Somatic cell-induced hyperacetylation, but not hypomethylation, positively and reversibly affects the efficiency of in vitro cloned blastocyst production in cattle. | 2011 | Cell Reprogram | pmid:21919704 |
| Zou CF et al. | Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. | 2011 | BMC Cancer | pmid:21244707 |
| Nandakumar V et al. | (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. | 2011 | Carcinogenesis | pmid:21209038 |
| Kang H and Roh S | Extended exposure to trichostatin A after activation alters the expression of genes important for early development in nuclear transfer murine embryos. | 2011 | J. Vet. Med. Sci. | pmid:21187677 |
| Mitmaker EJ et al. | Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors. | 2011 | Surgery | pmid:21193210 |
| Liao M et al. | Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription. | 2011 | J. Biol. Chem. | pmid:21193408 |
| Erb TM et al. | Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. | 2011 | Stem Cells Dev. | pmid:21204619 |
| Farinas B and Mas P | Functional implication of the MYB transcription factor RVE8/LCL5 in the circadian control of histone acetylation. | 2011 | Plant J. | pmid:21205033 |
| Host L et al. | Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition. | 2011 | J. Psychopharmacol. (Oxford) | pmid:19939859 |
| Muralidhar SA et al. | Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells. | 2011 | J. Biol. Chem. | pmid:21078662 |
| Chakravarty G et al. | Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. | 2011 | Cancer Biol. Ther. | pmid:21084857 |