| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Radiation Injuries | D011832 | 14 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Henderson C et al. | Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). | 2003 | J. Biol. Chem. | pmid:12556448 |
| Palazzo A et al. | Cell biology: Tubulin acetylation and cell motility. | 2003 | Nature | pmid:12529632 |
| Rahman MM et al. | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. | 2003 | Blood | pmid:12511413 |
| Musikacharoen T et al. | Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. | 2003 | J. Biol. Chem. | pmid:12511574 |
| Gusterson RJ et al. | The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. | 2003 | J. Biol. Chem. | pmid:12477714 |
| Haggarty SJ et al. | Small molecule modulation of the human chromatid decatenation checkpoint. | 2003 | Chem. Biol. | pmid:14700634 |
| Kim DK et al. | Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14667227 |
| Le Masson I et al. | Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. | 2003 | Mol. Cell. Biol. | pmid:12917332 |
| Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
| Condon JC et al. | A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12886011 |
| Kawai H et al. | Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. | 2003 | Int. J. Cancer | pmid:14506733 |
| Lopatina NG et al. | Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12810068 |
| Liu LT et al. | Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. | 2003 | Cancer Res. | pmid:12810630 |
| Shin HJ et al. | Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. | 2003 | Oncogene | pmid:12813458 |
| Kim TY et al. | Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. | 2003 | Oncogene | pmid:12813468 |
| Kim JM et al. | Changes in histone acetylation during mouse oocyte meiosis. | 2003 | J. Cell Biol. | pmid:12835313 |
| Hirose T et al. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | 2003 | Oncogene | pmid:14586402 |
| Cimini D et al. | Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. | 2003 | Mol. Biol. Cell | pmid:12972566 |
| Schuettengruber B et al. | Autoregulation of mouse histone deacetylase 1 expression. | 2003 | Mol. Cell. Biol. | pmid:12972616 |
| Yang Y et al. | The histone code regulating expression of the imprinted mouse Igf2r gene. | 2003 | Endocrinology | pmid:12975326 |
| Hu E et al. | Identification of novel isoform-selective inhibitors within class I histone deacetylases. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12975486 |
| Bouchain G et al. | Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:12593661 |
| Castro-Galache MD et al. | Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. | 2003 | Int. J. Cancer | pmid:12594812 |
| Teyssier C et al. | Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. | 2003 | Mol. Endocrinol. | pmid:12554755 |
| Kao HH et al. | Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. | 2003 Jan-Feb | J. Biomed. Sci. | pmid:12566991 |
| Kagoshima M et al. | How signaling pathways interact with gene transcription. | 2003 Jan-Mar | Monaldi Arch Chest Dis | pmid:14533280 |
| Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |
| Tong X et al. | Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15063780 |
| Kurtev V et al. | Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. | 2004 | J. Biol. Chem. | pmid:15140878 |
| Lemonde S et al. | Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. | 2004 | J. Neurochem. | pmid:14756806 |
| Hattori N et al. | Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. | 2004 | J. Biol. Chem. | pmid:14761969 |
| Milhem M et al. | Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A. | 2004 | Blood | pmid:14976039 |
| Agostinho M et al. | Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis. | 2004 | Mol. Biol. Cell | pmid:14978217 |
| Sakata R et al. | Trichostatin A activates the osteopontin gene promoter through AP1 site. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14985105 |
| Knobbe CB et al. | Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. | 2004 | J. Natl. Cancer Inst. | pmid:15026474 |
| Nan X et al. | Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15465025 |
| Lee HS et al. | Gene expression analysis in human gastric cancer cell line treated with trichostatin A and S-adenosyl-L-homocysteine using cDNA microarray. | 2004 | Biol. Pharm. Bull. | pmid:15467184 |
| GarcÃa I et al. | Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. | 2004 | Eukaryotic Cell | pmid:14871945 |
| Takai N et al. | Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. | 2004 | Clin. Cancer Res. | pmid:14871994 |
| Ishiguro K and Sartorelli AC | Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. | 2004 | Eur. J. Biochem. | pmid:15182353 |
| Brieger A et al. | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | 2004 | Biochem. Pharmacol. | pmid:15183120 |
| Shim JS et al. | Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. | 2004 | Oncogene | pmid:14661058 |
| Boehrer S et al. | In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. | 2004 | Leuk. Lymphoma | pmid:15359646 |
| Vaghefi H and Neet KE | Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. | 2004 | Oncogene | pmid:15361854 |
| Moore PS et al. | Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. | 2004 | Biochim. Biophys. Acta | pmid:15363630 |
| Schauber J et al. | Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. | 2004 | Mol. Immunol. | pmid:15261456 |
| De La Fuente R et al. | ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. | 2004 | Dev. Biol. | pmid:15242786 |
| Fang JY et al. | Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116. | 2004 | Cell Res. | pmid:15225415 |
| Banwell CM et al. | Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15225779 |
| Alao JP et al. | Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. | 2004 | Clin. Cancer Res. | pmid:15585645 |