| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Radiation Injuries | D011832 | 14 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ueda JY et al. | JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. | 2009 | J. Antibiot. | pmid:19300468 |
| Izawa M et al. | Inhibition of histone deacetylase causes reduction of appressorium formation in the rice blast fungus Magnaporthe oryzae. | 2009 | J. Gen. Appl. Microbiol. | pmid:20118613 |
| Guo W et al. | Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19700647 |
| Yamanaka K et al. | Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos. | 2009 | J. Reprod. Dev. | pmid:19700928 |
| McCulloch MW et al. | Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. | 2009 | Bioorg. Med. Chem. | pmid:19022675 |
| Yamada N et al. | Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. | 2009 | Br. J. Cancer | pmid:19127263 |
| Ku WC et al. | Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. | 2009 | Mol. Cell Proteomics | pmid:19505873 |
| Kondo T et al. | Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. | 2009 | Lab. Invest. | pmid:19506552 |
| Chandrasekaran S et al. | Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. | 2009 | FASEB J. | pmid:19638401 |
| Imesch P et al. | MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. | 2009 | Int. J. Oncol. | pmid:19639184 |
| Federman N et al. | Histone acetylation is recruited in consolidation as a molecular feature of stronger memories. | 2009 | Learn. Mem. | pmid:19794185 |
| Bao Y et al. | Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. | 2009 | Atherosclerosis | pmid:18930459 |
| Chen CZ et al. | The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well. | 2009 | Br. J. Pharmacol. | pmid:19785660 |
| Hoebeeck J et al. | Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. | 2009 | Cancer Lett. | pmid:18819746 |
| Susick L et al. | Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. | 2008 Sep-Oct | J. Cell. Mol. Med. | pmid:18053091 |
| Li X and Bai XZ | [NF-kappaB modulates activation of the BMP-2 gene by trichostatin A]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140318 |
| Kir'ianov GI et al. | [Nucleosome positioning within neomycinphosphotransferase gene (NPTII) on yeast plasmid in repressed and active state]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140324 |
| Miyoshi M et al. | Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells. | 2008 Nov-Dec | Nutrition | pmid:18723323 |
| Nishikiori N et al. | Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9. | 2008 May-Jun | Jpn. J. Ophthalmol. | pmid:18661270 |
| Fenic I et al. | In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. | 2008 Mar-Apr | J. Androl. | pmid:18046049 |
| Smetana K et al. | To the nucleolar density and size in apoptotic human leukemic myeloblasts produced in vitro by Trichostatin A. | 2008 Jul-Sep | Eur J Histochem | pmid:18840553 |
| Kovács P and Csaba G | The effect of histone deacetylase inhibitor trichostatin A (TSA) on the incorporation of 32P (Pi) and 3H-palmitic acid into the phospholipids of Tetrahymena. | 2008 Jan-Feb | Cell Biochem. Funct. | pmid:17191269 |
| Park H et al. | Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. | 2008 | Int. J. Mol. Med. | pmid:18949380 |
| Lin YC et al. | Effects of trichostatin A on neuronal mu-opioid receptor gene expression. | 2008 | Brain Res. | pmid:18950606 |
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| Gray SG et al. | Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. | 2008 | Clin Lung Cancer | pmid:19073520 |
| Zhu K et al. | Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. | 2008 | Arch. Gynecol. Obstet. | pmid:17680259 |
| Chou CW and Chen CC | HDAC inhibition upregulates the expression of angiostatic ADAMTS1. | 2008 | FEBS Lett. | pmid:19007777 |
| Nair S et al. | Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. | 2008 | Pharm. Res. | pmid:17657594 |
| Setiadi AF et al. | Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. | 2008 | Cancer Res. | pmid:19047136 |
| Mizumoto S et al. | The developmental potential of parthenogenetic and somatic cell nuclear-transferred rat oocytes in vitro. | 2008 | Cloning Stem Cells | pmid:19049415 |
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| Usami M et al. | Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. | 2008 | Nutr Res | pmid:19083427 |
| Krämer OH et al. | Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. | 2008 | Oncogene | pmid:17653085 |
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| Ramirez T et al. | Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. | 2008 | Chromosoma | pmid:17999076 |
| Nasu Y et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. | 2008 | Osteoarthr. Cartil. | pmid:18226559 |
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| Yoshioka H et al. | Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. | 2008 | J. Biol. Chem. | pmid:18801729 |
| Han JQ et al. | [Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18822204 |
| Pellicciotta I et al. | Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. | 2008 | Cancer Res. | pmid:18829567 |
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