| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Radiation Injuries | D011832 | 14 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sung TY et al. | Innovative in vitro chemo-hormonal drug therapy for refractory thyroid carcinomas. | 2012 | J. Korean Med. Sci. | pmid:22787366 |
| Oh HJ et al. | Trichostatin a improves preimplantation development of bovine cloned embryos and alters expression of epigenetic and pluripotency genes in cloned blastocysts. | 2012 | J. Vet. Med. Sci. | pmid:22785124 |
| Yao J et al. | ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism. | 2012 | Life Sci. | pmid:22781708 |
| Zheng L et al. | [Detecting acetylated proteins by affinity chromatography column]. | 2012 | Zhonghua Xue Ye Xue Za Zhi | pmid:22781610 |
| Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
| Tong K et al. | Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. | 2012 | Eukaryotic Cell | pmid:22771823 |
| Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
| Feng L et al. | Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. | 2013 | J. Mol. Med. | pmid:22763818 |
| Gan L et al. | Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. | 2012 | PLoS ONE | pmid:22761896 |
| Jasek E et al. | Effect of histone deacetylase inhibitors trichostatin A and valproic acid on etoposide-induced apoptosis in leukemia cells. | 2012 | Anticancer Res. | pmid:22753739 |
| Brose RD et al. | Activation of the stress proteome as a mechanism for small molecule therapeutics. | 2012 | Hum. Mol. Genet. | pmid:22752410 |
| Liu S et al. | Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. | 2013 | Ann. Surg. Oncol. | pmid:22752337 |
| Soleymani Fard S et al. | Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6). | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749740 |
| Scholl C et al. | Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain. | 2012 | BMC Genomics | pmid:22748179 |
| Zou Y et al. | Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia. | 2012 | J Hematol Oncol | pmid:22747680 |
| Chen H et al. | LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. | 2012 | Cancer Lett. | pmid:22743615 |
| Balmer NV et al. | Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. | 2012 | Hum. Mol. Genet. | pmid:22723015 |
| He Q et al. | Characterization of an apical ceramide-enriched compartment regulating ciliogenesis. | 2012 | Mol. Biol. Cell | pmid:22718902 |
| Kan R et al. | Potential role for PADI-mediated histone citrullination in preimplantation development. | 2012 | BMC Dev. Biol. | pmid:22712504 |
| Itoh M et al. | Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation. | 2013 | J. Mol. Neurosci. | pmid:22711563 |
| Zhang YW et al. | Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. | 2012 | PLoS ONE | pmid:22701735 |
| Nunes MJ et al. | Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway. | 2012 | J. Lipid Res. | pmid:22693257 |
| Jung N et al. | Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma. | 2012 | J. Korean Med. Sci. | pmid:22690089 |
| Royce SG et al. | Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice. | 2012 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:22684086 |
| Kim Y et al. | Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. | 2012 | J. Biol. Chem. | pmid:22679019 |
| Mitchell MD et al. | Epigenetic regulation of cytokine production in human amnion and villous placenta. | 2012 | Mediators Inflamm. | pmid:22665947 |
| Glait-Santar C et al. | Expression pattern of SVEP1 alternatively-spliced forms. | 2012 | Gene | pmid:22659106 |
| Orlova DY et al. | Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. | 2012 | J. Cell. Biochem. | pmid:22644811 |
| Buurman R et al. | Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. | 2012 | Gastroenterology | pmid:22641068 |
| Kim YS et al. | Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22634317 |
| Wu TC et al. | Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22626855 |
| Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
| Dhawan D et al. | DNMT1: an emerging target in the treatment of invasive urinary bladder cancer. | 2013 | Urol. Oncol. | pmid:22609058 |
| Hsu DW et al. | Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. | 2012 | Nucleic Acids Res. | pmid:22600736 |
| Truong M et al. | Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence. | 2012 | Br. J. Cancer | pmid:22596233 |
| Park J et al. | ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22580278 |
| Srirattana K et al. | Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22578161 |
| Hizume K et al. | Nano-scale analyses of the chromatin decompaction induced by histone acetylation. | 2010 | Arch. Histol. Cytol. | pmid:22572182 |
| Bobkov DE et al. | [Isolation of tropomyosin particles from the cytosol of cultured cells and their protein composition analysis]. | 2012 | Tsitologiia | pmid:22567898 |
| Yu L et al. | Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis. | 2012 | Arch. Med. Res. | pmid:22564421 |
| Catalano MG et al. | Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22563106 |
| He M and Guo Q | [Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22561570 |
| Cheng SP et al. | Regulation of leptin receptor expression in human papillary thyroid cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22560341 |
| Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
| Hsieh TH et al. | Phthalates stimulate the epithelial to mesenchymal transition through an HDAC6-dependent mechanism in human breast epithelial stem cells. | 2012 | Toxicol. Sci. | pmid:22552774 |
| Meng J et al. | The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. | 2012 | Oncol. Rep. | pmid:22552631 |
| Kang FW et al. | Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. | 2012 | Oncol. Rep. | pmid:22552321 |
| Reddy P | Editorial: HDAC inhibition begets more MDSCs. | 2012 | J. Leukoc. Biol. | pmid:22547132 |
| Chawalit S et al. | Trichostatin A and ascorbic acid assist in the development of porcine handmade cloned embryos via different physiologic pathways. | 2012 | Reprod Sci | pmid:22534331 |
| Li Q and Chen H | Silencing of Wnt5a during colon cancer metastasis involves histone modifications. | 2012 | Epigenetics | pmid:22522911 |