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The major histocompatibility complex class II transactivator is differentially regulated by interferon-gamma and transforming growth factor-beta in microglial cells. |
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[Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. |
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Hum. Gene Ther. |
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Gastroenterology |
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Lancet Neurol |
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Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. |
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Mol. Cell. Probes |
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Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count. |
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Cell Cycle |
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Histone deacetylation is required for orderly meiosis. |
2006 |
Cell Cycle |
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Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. |
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Mol. Cell |
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Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation. |
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Carcinogenesis |
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Invest. Ophthalmol. Vis. Sci. |
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Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. |
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Biol. Chem. |
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Arthritis Rheum. |
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Ann. Rheum. Dis. |
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NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. |
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Prostate |
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MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. |
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Int. J. Cancer |
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Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. |
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Mol. Cell. Biochem. |
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Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. |
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Circulation |
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Alcohol. Clin. Exp. Res. |
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Mol. Biol. Cell |
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HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. |
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Cancer Res. |
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Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. |
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Mol. Cell. Biol. |
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Identification of novel target genes by an epigenetic reactivation screen of renal cancer. |
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Cancer Res. |
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Neuroscience |
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Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. |
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Mol. Cell. Biol. |
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Oncogene |
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Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. |
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Int. J. Cancer |
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Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. |
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Mol. Endocrinol. |
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Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. |
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J. Neurosci. |
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5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. |
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Leuk. Res. |
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Epigenetic regulation of lentiviral transgene vectors in a large animal model. |
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Mol. Ther. |
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Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. |
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Mol. Endocrinol. |
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Exp. Mol. Med. |
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Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. |
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NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. |
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Pharmacol. Res. |
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Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. |
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Arterioscler. Thromb. Vasc. Biol. |
pmid:17008592
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Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. |
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Cloning Stem Cells |
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[Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. |
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Ai Zheng |
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Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. |
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Cancer Lett. |
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Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. |
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Biochem. Biophys. Res. Commun. |
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Synthesis of rigid trichostatin A analogs as HDAC inhibitors. |
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Bioorg. Med. Chem. Lett. |
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Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). |
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J. Atheroscler. Thromb. |
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Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. |
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J. Leukoc. Biol. |
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Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. |
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Endocr. Relat. Cancer |
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Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. |
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Mol. Hum. Reprod. |
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Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells. |
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Pharmazie |
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A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. |
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BMC Cancer |
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Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. |
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J. Med. Chem. |
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Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. |
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Cancer Res. |
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Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. |
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Protist |
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MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Regulation of the prepronociceptin gene and its effect on neuronal differentiation. |
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Gene |
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An ex vivo method for rapid generation of monoclonal antibodies (ADLib system). |
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Nat Protoc |
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Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. |
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Int. J. Oncol. |
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Telomere position effect and silencing of transgenes near telomeres in the mouse. |
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Mol. Cell. Biol. |
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Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer. |
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Biol. Reprod. |
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Role of histone deacetylase in the expression of CTP:phosphocholine cytidylyltransferase alpha. |
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J. Biol. Chem. |
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Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. |
2006 |
Cancer Chemother. Pharmacol. |
pmid:16435155
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Deng G et al. |
Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. |
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Int. J. Cancer |
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Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. |
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Neurosci. Lett. |
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Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. |
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Clin. Cancer Res. |
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Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. |
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Clin. Gastroenterol. Hepatol. |
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Tumor suppressor p53 regulates heparanase gene expression. |
2006 |
Oncogene |
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Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. |
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Nucleic Acids Res. |
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