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Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. |
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Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. |
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2003 |
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An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
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2003 |
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Oncogene |
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2003 |
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Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. |
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Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation. |
2003 |
Oncogene |
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Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. |
2003 |
Glia |
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The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. |
2003 |
BMC Cancer |
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2003 |
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2003 |
Carcinogenesis |
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2003 |
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2003 |
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Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. |
2003 |
Blood |
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2003 |
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Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. |
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Oncogene |
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2003 |
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2003 |
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Oncogene |
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2003 |
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2003 |
Oncogene |
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2003 |
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Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. |
2003 |
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A multistep mechanism for the activation of rearrangement in the immune system. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
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Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. |
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J. Hematother. Stem Cell Res. |
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2003 |
Biochem. Biophys. Res. Commun. |
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The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. |
2003 |
Am. J. Respir. Cell Mol. Biol. |
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Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. |
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Biol. Chem. |
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Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. |
2003 |
Cancer Sci. |
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Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. |
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Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. |
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Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation. |
2003 |
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Histone deacetylase inhibitors activate p21(WAF1) expression via ATM. |
2003 |
Cancer Res. |
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The transcriptional enhancer of the pea plastocyanin gene associates with the nuclear matrix and regulates gene expression through histone acetylation. |
2003 |
Plant Cell |
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Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A. |
2003 |
Electrophoresis |
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2003 |
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Ab initio study of the binding of Trichostatin A (TSA) in the active site of histone deacetylase like protein (HDLP). |
2003 |
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2003 |
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Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. |
2003 |
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Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. |
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Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. |
2003 |
Gut |
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Generation of hepatocyte-like cells from human embryonic stem cells. |
2003 |
Cell Transplant |
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2003 |
Mol. Immunol. |
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Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. |
2003 |
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Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. |
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Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. |
2003 |
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Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. |
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Histone acetylation and gastrointestinal carcinogenesis. |
2003 |
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Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. |
2003 |
Mol. Cell. Biol. |
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The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. |
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The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. |
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Anticancer drug shows promise against lupus. |
2003 |
Drug Discov. Today |
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Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. |
2003 |
Int. J. Oncol. |
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Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. |
2003 |
J. Steroid Biochem. Mol. Biol. |
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Histone acetylation-mediated regulation of genes in leukaemic cells. |
2003 |
Eur. J. Cancer |
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The mechanism of 3'-azido-2',3'-dideoxythymidine resistance to human lymphoid cells. |
2003 |
Int. J. Mol. Med. |
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