trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Osteomalacia D010018 5 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Progeria D011371 3 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Radiation Injuries D011832 14 associated lipids
Retinoblastoma D012175 12 associated lipids
Rubinstein-Taybi Syndrome D012415 1 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Mogal AP et al. Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation. 2007 J. Biol. Chem. pmid:17602165
Kang JH et al. Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. 2007 Exp. Mol. Med. pmid:17603295
Subramanian C et al. CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A. 2007 Neoplasia pmid:17603632
Chen B and Cepko CL Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. 2007 BMC Dev. Biol. pmid:17603891
Glenisson W et al. Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. 2007 Biochim. Biophys. Acta pmid:17610967
Ehrenkaufer GM et al. Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. 2007 BMC Genomics pmid:17612405
Platta CS et al. The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. 2007 J. Surg. Res. pmid:17612559
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Kato N et al. Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells. 2007 Leukemia pmid:17625602
Bu Y and Gelman IH v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. 2007 J. Biol. Chem. pmid:17626016
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Ho AK et al. Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. 2007 Endocrinology pmid:17628002
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Kaida D et al. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. 2007 Nat. Chem. Biol. pmid:17643111
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Wu Y et al. The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. 2007 Genes Cells pmid:17663720
Huber LC et al. Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. 2007 Arthritis Rheum. pmid:17665426
El-Khoury V et al. The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model. 2007 Br. J. Cancer pmid:17667922
Khaw AK et al. Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells. 2007 Mutat. Res. pmid:17669439
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Gahr S et al. The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. 2007 Int. J. Oncol. pmid:17671683
Tomita A et al. Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy. 2007 Int. J. Hematol. pmid:17675267
Wang J et al. Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. 2007 J. Biol. Chem. pmid:17675290
Tuncel M et al. The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. 2007 Cancer Biother. Radiopharm. pmid:17679169
Zhu K et al. Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. 2008 Arch. Gynecol. Obstet. pmid:17680259
Sun DF et al. [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. 2007 Zhonghua Yi Xue Yi Chuan Xue Za Zhi pmid:17680526
Zhou X et al. The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. 2007 Cancer Genet. Cytogenet. pmid:17693185
Ragno R et al. Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies. 2008 Eur J Med Chem pmid:17698257
Jamaluddin MD et al. Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. 2007 Blood pmid:17698632
Hong S et al. Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A. 2007 Anticancer Drugs pmid:17704650
Byers J and Eichinger D Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. 2008 Int. J. Parasitol. pmid:17706222
Robertson DM et al. Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium. 2007 Exp. Eye Res. pmid:17709104
Chen WY et al. Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1). 2007 Mol. Cell. Biol. pmid:17709382
D'Alessio AC et al. Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. 2007 Mol. Cell. Biol. pmid:17709385
Tsaprouni LG et al. Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. 2007 Clin. Exp. Immunol. pmid:17711487
Yasukawa K et al. Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts. 2007 Br. J. Dermatol. pmid:17711521
Frye M et al. Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. 2007 PLoS ONE pmid:17712411
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Zhang Y et al. Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. 2007 Radiat. Res. pmid:17722998
Campanero MR et al. The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. 2008 Oncogene pmid:17724474
Manning J et al. Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. 2008 Immunology pmid:17725605
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Pryzbylkowski P et al. Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. 2008 Breast Cancer Res. Treat. pmid:17891453
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Kim EJ et al. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. 2007 Mol. Cell pmid:17964266
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Putnik J et al. The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60. 2007 Biochim. Biophys. Acta pmid:17980166
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Gan Y et al. Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. 2008 Biochem. Biophys. Res. Commun. pmid:17996726
Ramirez T et al. Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. 2008 Chromosoma pmid:17999076
Malinen M et al. Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3. 2008 Nucleic Acids Res. pmid:17999998