| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteomalacia | D010018 | 5 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Progeria | D011371 | 3 associated lipids |
| Prostatic Hyperplasia | D011470 | 20 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Radiation Injuries | D011832 | 14 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Mast-Cell Sarcoma | D012515 | 9 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen T et al. | Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. | 2002 | Arch. Biochem. Biophys. | pmid:12464268 |
| Rombouts K et al. | Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. | 2002 | J. Hepatol. | pmid:12445420 |
| Guo WH et al. | Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. | 2002 | Oncogene | pmid:12447699 |
| Marin-Husstege M et al. | Histone deacetylase activity is necessary for oligodendrocyte lineage progression. | 2002 | J. Neurosci. | pmid:12451133 |
| Wang ZM et al. | Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. | 2002 | Ai Zheng | pmid:12508652 |
| Duharcourt S and Yao MC | Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. | 2002 | Eukaryotic Cell | pmid:12455963 |
| Strait KA et al. | Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. | 2002 | Mol. Cancer Ther. | pmid:12479699 |
| Kiefer SM et al. | Murine Sall1 represses transcription by recruiting a histone deacetylase complex. | 2002 | J. Biol. Chem. | pmid:11836251 |
| Roddie PH et al. | Primary acute myeloid leukaemia blasts resistant to cytokine-induced differentiation to dendritic-like leukaemia cells can be forced to differentiate by the addition of bryostatin-1. | 2002 | Leukemia | pmid:11840267 |
| Taniura S et al. | Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells. | 2002 | J. Biol. Chem. | pmid:11877441 |
| Heltweg B and Jung M | A microplate reader-based nonisotopic histone deacetylase activity assay. | 2002 | Anal. Biochem. | pmid:11878795 |
| Kamitani H et al. | Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced. | 2002 | Neuro-oncology | pmid:11916500 |
| Kishikawa S et al. | Roles of histone acetylation in the Dnmt1 gene expression. | 2002 | Nucleic Acids Res. Suppl. | pmid:12903179 |
| Ginjala V et al. | Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. | 2002 | J. Biol. Chem. | pmid:11777900 |
| Cabral AL et al. | Regulation of the cellular prion protein gene expression depends on chromatin conformation. | 2002 | J. Biol. Chem. | pmid:11739375 |
| Park SH et al. | Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. | 2002 | J. Biol. Chem. | pmid:11744689 |
| Suenaga M et al. | Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. | 2002 | Int. J. Cancer | pmid:11807787 |
| Choi HS et al. | Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12200149 |
| Maecker HL et al. | Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. | 2002 | Cancer Cell | pmid:12204534 |
| Fang D et al. | Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. | 2002 | Nucleic Acids Res. | pmid:12136092 |
| Zschocke J et al. | Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells. | 2002 | J. Biol. Chem. | pmid:12138116 |
| Yu Z et al. | Histone deacetylases augment cytokine induction of the iNOS gene. | 2002 | J. Am. Soc. Nephrol. | pmid:12138131 |
| Li J et al. | Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. | 2002 | Mol. Cell. Biol. | pmid:12138181 |
| Aapola U et al. | Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. | 2002 | Nucleic Acids Res. | pmid:12177302 |
| Chang TH and Szabo E | Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. | 2002 | Clin. Cancer Res. | pmid:11948134 |
| Ventura A et al. | The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. | 2002 | J. Biol. Chem. | pmid:11948181 |
| Gradoville L et al. | Protein kinase C-independent activation of the Epstein-Barr virus lytic cycle. | 2002 | J. Virol. | pmid:11991990 |
| Uesato S et al. | Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11992774 |
| Nambiar MP et al. | Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling. | 2002 | J. Cell. Biochem. | pmid:11967985 |
| Fu M et al. | Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. | 2002 | Mol. Cell. Biol. | pmid:11971970 |
| Bharadwaj S and Prasad GL | Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. | 2002 | Cancer Lett. | pmid:12065096 |
| Ito K et al. | A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12070353 |
| Katula KS et al. | Cell cycle specific changes in the human cyclin B1 gene regulatory region as revealed by response to trichostatin A. | 2002 | Arch. Biochem. Biophys. | pmid:12054478 |
| Wang XQ et al. | Histone deacetylase inhibition results in decreased macrophage CD9 expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12056820 |
| Rahmani M et al. | The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process. | 2002 | Exp. Cell Res. | pmid:12061815 |
| Woo SH et al. | Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. | 2002 | J. Med. Chem. | pmid:12061890 |
| Chen Y et al. | On the epigenetic regulation of the human reelin promoter. | 2002 | Nucleic Acids Res. | pmid:12087179 |
| Zhang Y and Dufau ML | Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. | 2002 | J. Biol. Chem. | pmid:12091390 |
| Danbara M et al. | DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. | 2002 | Mol. Immunol. | pmid:12044782 |
| Lin HM et al. | Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. | 2002 | J. Biol. Chem. | pmid:12048199 |
| Quivy V et al. | Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. | 2002 | J. Virol. | pmid:12368351 |
| Smith WL and Edlind TD | Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. | 2002 | Antimicrob. Agents Chemother. | pmid:12384361 |
| Im H et al. | Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. | 2002 | Biochemistry | pmid:12484752 |
| Gong XQ and Li L | Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. | 2002 | J. Biol. Chem. | pmid:11809751 |
| Rössig L et al. | Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. | 2002 | Circ. Res. | pmid:12411399 |
| McGuinness MC et al. | Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. | 2001 Sep-Oct | Mol. Genet. Metab. | pmid:11592822 |
| Rombouts K et al. | Trichostatin A, lead compound for development of antifibrogenic drugs. | 2001 Jul-Sep | Acta Gastroenterol. Belg. | pmid:11680040 |
| Jorgensen JS and Nilson JH | AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. | 2001 | Mol. Endocrinol. | pmid:11518798 |
| Wang H et al. | Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. | 2001 | Science | pmid:11387442 |
| Feng YQ et al. | Position effects are influenced by the orientation of a transgene with respect to flanking chromatin. | 2001 | Mol. Cell. Biol. | pmid:11113204 |