trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Nerve Degeneration D009410 53 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasms D009369 13 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Nasal Polyps D009298 26 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Intellectual Disability D008607 13 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with trichostatin A?

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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Huang W et al. Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. 2005 J. Biol. Chem. pmid:15647279
Choi JH et al. Trichostatin A attenuates airway inflammation in mouse asthma model. 2005 Clin. Exp. Allergy pmid:15649272
Varshochi R et al. ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. 2005 J. Biol. Chem. pmid:15557281
Goeman F et al. Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. 2005 Mol. Cell. Biol. pmid:15601862
Tai HH et al. Dynamic histone acetylation of late embryonic genes during seed germination. 2005 Plant Mol. Biol. pmid:16307366
Marchion DC et al. Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. 2005 Clin. Cancer Res. pmid:16322310
Farrajota K et al. Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. 2005 Arthritis Rheum. pmid:15641079
Noh EJ et al. Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells. 2005 Cancer Res. pmid:16357148
Wetzel M et al. Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis. 2005 J. Neurosurg. pmid:16383255
Place RF et al. HDACs and the senescent phenotype of WI-38 cells. 2005 BMC Cell Biol. pmid:16250917
Lee JH et al. Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1. 2005 J. Endocrinol. pmid:16293776
Hazzalin CA and Mahadevan LC Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. 2005 PLoS Biol. pmid:16262446
Hohl M and Thiel G Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. 2005 Eur. J. Neurosci. pmid:16262660
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Li XX et al. Function of c-Fos-like and c-Jun-like proteins on trichostatin A-induced G2/M arrest in Physarum polycephalum. 2005 Acta Biochim. Biophys. Sin. (Shanghai) pmid:16270156
Francia G et al. Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents. 2005 Mol. Cancer Ther. pmid:16227397
Chou SD et al. Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. 2005 Int. Immunol. pmid:16210330
Bai Y et al. Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. 2005 J. Immunol. pmid:16210620
Chen G et al. [Enhancive effect of histone deacetylase inhibitor trichostatin a on transfection efficiency of adenovirus in ovarian carcinoma cell line A2780]. 2005 Ai Zheng pmid:16219132
Kasper LH et al. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. 2005 EMBO J. pmid:16237459
Chang S and Pikaard CS Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. 2005 J. Biol. Chem. pmid:15516340
Osada H et al. Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. 2005 Mol. Carcinog. pmid:16163707
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Curtin BF et al. Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. 2005 J. Cell. Biochem. pmid:16149071
Chen JS and Faller DV Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. 2005 J. Cell. Physiol. pmid:15389542
Medugno L et al. The Krüppel-like zinc-finger protein ZNF224 represses aldolase A gene transcription by interacting with the KAP-1 co-repressor protein. 2005 Gene pmid:16150558
Frønsdal K and Saatcioglu F Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. 2005 Prostate pmid:15389787
Johnson J et al. Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid. 2005 Cell. Mol. Biol. (Noisy-le-grand) pmid:16171558
Karagiannis TC et al. The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X. 2005 Cancer Biol. Ther. pmid:16082178
Xiong Y et al. Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. 2005 Gynecol. Oncol. pmid:16024066
Somech R et al. The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. 2005 J. Cell. Sci. pmid:16129885
Cho HH et al. Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. 2005 J. Cell. Biochem. pmid:16088945
Lin KT et al. Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. 2005 J. Biomed. Sci. pmid:16132114
Smardová J et al. CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. 2005 Differentiation pmid:16026544
Fandy TE et al. Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. 2005 Neoplasia pmid:16026644
Korutla L et al. The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. 2005 J. Neurochem. pmid:16033423
Shindo N et al. The ESC-E(Z) complex participates in the hedgehog signaling pathway. 2005 Biochem. Biophys. Res. Commun. pmid:15652519
Kemp MG et al. The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. 2005 Nucleic Acids Res. pmid:15653633
Huang H et al. MEIS C termini harbor transcriptional activation domains that respond to cell signaling. 2005 J. Biol. Chem. pmid:15654074
Danam RP et al. Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. 2005 Mol. Cancer Ther. pmid:15657354
Li Y et al. Histone deacetylation is required for progression through mitosis in tobacco cells. 2005 Plant J. pmid:15659094
Zhao Y et al. Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. 2005 J. Exp. Biol. pmid:15695762
Hooven LA et al. Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. 2005 Bioorg. Med. Chem. Lett. pmid:15713371
Chen B et al. Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors. 2005 Bioorg. Med. Chem. Lett. pmid:15713393
Duan H et al. Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. 2005 Mol. Cell. Biol. pmid:15713621
Tong X et al. Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. 2005 J. Biol. Chem. pmid:15713675
Gan Y et al. Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. 2005 J. Biol. Chem. pmid:15722551
Endo M et al. Novel gender-related regulation of CYP2C12 gene expression in rats. 2005 Mol. Endocrinol. pmid:15661834
Ranganathan P and Rangnekar VM Exploiting the TSA connections to overcome apoptosis-resistance. 2005 Cancer Biol. Ther. pmid:15908800
Rincón-Arano H et al. YY1 and GATA-1 interaction modulate the chicken 3'-side alpha-globin enhancer activity. 2005 J. Mol. Biol. pmid:15913647
Galfi P et al. Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. 2005 J. Steroid Biochem. Mol. Biol. pmid:15862948
Choi KH et al. Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine. 2005 Glycoconj. J. pmid:15864436
Touma SE et al. Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. 2005 Clin. Cancer Res. pmid:15867260
Fish JE et al. The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. 2005 J. Biol. Chem. pmid:15870070
Dyson MH et al. MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. 2005 J. Cell. Sci. pmid:15870105
Reid G et al. Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. 2005 Oncogene pmid:15870696
Kim MS et al. Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). 2005 Exp. Cell Res. pmid:15878336
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Robbins AR et al. Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin. 2005 Cell Cycle pmid:15846093
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Magner WJ and Tomasi TB Apoptotic and necrotic cells induced by different agents vary in their expression of MHC and costimulatory genes. 2005 Mol. Immunol. pmid:15829293
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