Wittich S et al. |
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. |
2002 |
J. Med. Chem. |
pmid:12109913
|
Toyooka S et al. |
Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures. |
2002 |
Clin. Cancer Res. |
pmid:12114433
|
Waterborg JH and Kapros T |
Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa. |
2002 |
Biochem. Cell Biol. |
pmid:12123281
|
Mikkelsen IM et al. |
Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif. |
2002 |
Biochem. Pharmacol. |
pmid:12123752
|
Petti MC et al. |
Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies. |
2002 |
Blood |
pmid:12130525
|
Fang D et al. |
Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. |
2002 |
Nucleic Acids Res. |
pmid:12136092
|
Zschocke J et al. |
Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells. |
2002 |
J. Biol. Chem. |
pmid:12138116
|
Yu Z et al. |
Histone deacetylases augment cytokine induction of the iNOS gene. |
2002 |
J. Am. Soc. Nephrol. |
pmid:12138131
|
Li J et al. |
Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. |
2002 |
Mol. Cell. Biol. |
pmid:12138181
|
Rahman I et al. |
Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. |
2002 May-Jun |
Mol. Cell. Biochem. |
pmid:12162440
|
Noss KR et al. |
Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. |
2002 May-Jun |
Anticancer Res. |
pmid:12168830
|
Rombouts K et al. |
Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. |
2002 |
Exp. Cell Res. |
pmid:12169274
|
Aapola U et al. |
Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. |
2002 |
Nucleic Acids Res. |
pmid:12177302
|
Avram D et al. |
COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. |
2002 |
Biochem. J. |
pmid:12196208
|
Guo Y et al. |
Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. |
2002 |
J. Biol. Chem. |
pmid:12198113
|
Choi HS et al. |
Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:12200149
|
Maecker HL et al. |
Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. |
2002 |
Cancer Cell |
pmid:12204534
|
Kostyniuk CL et al. |
The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. |
2002 |
Oncogene |
pmid:12214274
|
Hall IM et al. |
Establishment and maintenance of a heterochromatin domain. |
2002 |
Science |
pmid:12215653
|
Lynch CA et al. |
Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. |
2002 |
Mol. Cancer |
pmid:12234381
|
Suzuki-Mizushima Y et al. |
Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. |
2002 |
Brain Res. |
pmid:12270499
|
Quivy V et al. |
Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. |
2002 |
J. Virol. |
pmid:12368351
|
Ego T et al. |
The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. |
2002 |
Oncogene |
pmid:12370815
|
Zhang W and Kone BC |
NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases. |
2002 |
Am. J. Physiol. Renal Physiol. |
pmid:12372765
|
Ailenberg M and Silverman M |
Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:12379227
|
Smith WL and Edlind TD |
Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. |
2002 |
Antimicrob. Agents Chemother. |
pmid:12384361
|
Harada K et al. |
Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. |
2002 |
Cancer Res. |
pmid:12384554
|
Hauser C et al. |
Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. |
2002 |
Mol. Cell. Biol. |
pmid:12391151
|
Westendorf JJ et al. |
Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. |
2002 |
Mol. Cell. Biol. |
pmid:12391164
|
Witt O et al. |
Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. |
2003 |
Blood |
pmid:12393499
|
Yang L et al. |
An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. |
2003 |
Biochem. J. |
pmid:12398767
|
Bereshchenko OR et al. |
Acetylation inactivates the transcriptional repressor BCL6. |
2002 |
Nat. Genet. |
pmid:12402037
|
Chen Z et al. |
Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. |
2002 |
Cancer Lett. |
pmid:12406558
|
Gálfi P et al. |
Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. |
2002 |
Cancer Lett. |
pmid:12406559
|
Rössig L et al. |
Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. |
2002 |
Circ. Res. |
pmid:12411399
|
Travers H et al. |
Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. |
2002 |
Exp. Cell Res. |
pmid:12413881
|
Wilson AJ et al. |
Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. |
2002 |
Cancer Res. |
pmid:12414619
|
Choy JS and Kron SJ |
NuA4 subunit Yng2 function in intra-S-phase DNA damage response. |
2002 |
Mol. Cell. Biol. |
pmid:12417725
|
Ghoshal K et al. |
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. |
2002 |
Mol. Cell. Biol. |
pmid:12417732
|
Zhang J et al. |
Establishment of transcriptional competence in early and late S phase. |
2002 |
Nature |
pmid:12432398
|
Kim JY et al. |
Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation. |
2002 |
Anal. Chem. |
pmid:12433071
|
Elaut G et al. |
Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes. |
2002 |
Drug Metab. Dispos. |
pmid:12433798
|
Yáñez RJ and Porter AC |
A chromosomal position effect on gene targeting in human cells. |
2002 |
Nucleic Acids Res. |
pmid:12433992
|
Takechi S et al. |
Chicken HDAC2 down-regulates IgM light chain gene promoter activity. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:12437980
|
Rombouts K et al. |
Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. |
2002 |
J. Hepatol. |
pmid:12445420
|
Guo WH et al. |
Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. |
2002 |
Oncogene |
pmid:12447699
|
Marin-Husstege M et al. |
Histone deacetylase activity is necessary for oligodendrocyte lineage progression. |
2002 |
J. Neurosci. |
pmid:12451133
|
Duharcourt S and Yao MC |
Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. |
2002 |
Eukaryotic Cell |
pmid:12455963
|
Chen T et al. |
Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. |
2002 |
Arch. Biochem. Biophys. |
pmid:12464268
|
Iwata K et al. |
Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. |
2002 Jul-Aug |
Cell. Immunol. |
pmid:12470611
|
Scott GK et al. |
Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. |
2002 |
Mol. Cancer Ther. |
pmid:12477051
|
Gusterson RJ et al. |
The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. |
2003 |
J. Biol. Chem. |
pmid:12477714
|
Strait KA et al. |
Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. |
2002 |
Mol. Cancer Ther. |
pmid:12479699
|
Blagosklonny MV et al. |
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. |
2002 |
Mol. Cancer Ther. |
pmid:12481415
|
Kondo Y et al. |
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. |
2003 |
Mol. Cell. Biol. |
pmid:12482974
|
Ding Z et al. |
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. |
2003 |
Mol. Cell. Biol. |
pmid:12482978
|
Im H et al. |
Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. |
2002 |
Biochemistry |
pmid:12484752
|
Boutillier AL et al. |
Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. |
2002 |
Ann. N. Y. Acad. Sci. |
pmid:12485907
|
Dogra SC et al. |
Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. |
2003 |
Mol. Pharmacol. |
pmid:12488538
|
Zarnegar R et al. |
Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. |
2002 |
Surgery |
pmid:12490845
|
Lietz M et al. |
RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. |
2003 |
Eur. J. Biochem. |
pmid:12492469
|
Yamashita Y et al. |
Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. |
2003 |
Int. J. Cancer |
pmid:12494463
|
Thomas RM et al. |
Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen. |
2003 |
J. Immunol. |
pmid:12496403
|
Yamashita K et al. |
Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. |
2002 |
Cancer Cell |
pmid:12498717
|
Fahrner JA et al. |
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. |
2002 |
Cancer Res. |
pmid:12499261
|
Wang ZM et al. |
Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. |
2002 |
Ai Zheng |
pmid:12508652
|
Rahman MM et al. |
Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. |
2003 |
Blood |
pmid:12511413
|
Musikacharoen T et al. |
Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. |
2003 |
J. Biol. Chem. |
pmid:12511574
|
Palazzo A et al. |
Cell biology: Tubulin acetylation and cell motility. |
2003 |
Nature |
pmid:12529632
|
Fernandes I et al. |
Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. |
2003 |
Mol. Cell |
pmid:12535528
|
Sonoyama K et al. |
Upregulation of activin A gene by butyrate in human colon cancer cell lines. |
2003 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:12540370
|
Kagoshima M et al. |
Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. |
2003 |
Biochem. Soc. Trans. |
pmid:12546654
|
Teyssier C et al. |
Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. |
2003 |
Mol. Endocrinol. |
pmid:12554755
|
Henderson C et al. |
Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). |
2003 |
J. Biol. Chem. |
pmid:12556448
|
Cheutin T et al. |
Maintenance of stable heterochromatin domains by dynamic HP1 binding. |
2003 |
Science |
pmid:12560555
|
Boutillier AL et al. |
Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. |
2003 |
J. Neurochem. |
pmid:12562525
|
Tomita K et al. |
The effect of oxidative stress on histone acetylation and IL-8 release. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12565901
|
Kao HH et al. |
Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. |
2003 Jan-Feb |
J. Biomed. Sci. |
pmid:12566991
|
Bhat RA et al. |
Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. |
2003 |
Plant J. |
pmid:12581304
|
Jang IC et al. |
Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. |
2003 |
Plant J. |
pmid:12581311
|
Kim Y et al. |
Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. |
2003 |
Oncogene |
pmid:12584561
|
López-Solache I et al. |
Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. |
2002 |
Endocrine |
pmid:12588052
|
Mishra N et al. |
Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. |
2003 |
J. Clin. Invest. |
pmid:12588892
|
Glaser KB et al. |
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. |
2003 |
Mol. Cancer Ther. |
pmid:12589032
|
Bouchain G et al. |
Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. |
2003 |
J. Med. Chem. |
pmid:12593661
|
Castro-Galache MD et al. |
Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. |
2003 |
Int. J. Cancer |
pmid:12594812
|
Ailenberg M and Silverman M |
Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12604329
|
Sakai N et al. |
Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. |
2003 |
J. Biol. Chem. |
pmid:12609987
|
Kim SY et al. |
Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. |
2003 |
J. Virol. |
pmid:12610114
|
Wang S and Zhu J |
Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. |
2003 |
J. Biol. Chem. |
pmid:12611896
|
Shaker S et al. |
Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. |
2003 |
Leuk. Res. |
pmid:12620295
|
Sawa H et al. |
Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. |
2002 |
Brain Tumor Pathol |
pmid:12622137
|
Camarero N et al. |
Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. |
2003 |
Nucleic Acids Res. |
pmid:12626711
|
Huang Y et al. |
Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. |
2003 |
Int. J. Cancer |
pmid:12640681
|
Shi W et al. |
Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. |
2003 |
Biol. Reprod. |
pmid:12646489
|
Murumägi A et al. |
Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. |
2003 |
J. Biol. Chem. |
pmid:12651856
|
Chandler SP et al. |
Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. |
2003 |
BMC Mol. Biol. |
pmid:12659659
|
Kao GD et al. |
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. |
2003 |
J. Cell Biol. |
pmid:12668657
|
Vos MD et al. |
The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. |
2003 |
J. Biol. Chem. |
pmid:12676952
|
Detich N et al. |
The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. |
2003 |
J. Biol. Chem. |
pmid:12676953
|