| MeSH term | MeSH ID | Detail |
|---|---|---|
| Chondrosarcoma | D002813 | 9 associated lipids |
| Osteomalacia | D010018 | 5 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Lymphatic Metastasis | D008207 | 10 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lin YC et al. | Effects of trichostatin A on neuronal mu-opioid receptor gene expression. | 2008 | Brain Res. | pmid:18950606 |
| Haffner I et al. | Regulation of arginase-1 expression in macrophages by a protein kinase A type I and histone deacetylase dependent pathway. | 2008 | J. Cell. Biochem. | pmid:17577214 |
| Mizumoto S et al. | The developmental potential of parthenogenetic and somatic cell nuclear-transferred rat oocytes in vitro. | 2008 | Cloning Stem Cells | pmid:19049415 |
| Slack MD et al. | Characterizing heterogeneous cellular responses to perturbations. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19052231 |
| Chittur SV et al. | Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | 2008 | BMC Genomics | pmid:18959802 |
| Ramirez T et al. | Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. | 2008 | Chromosoma | pmid:17999076 |
| Malinen M et al. | Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3. | 2008 | Nucleic Acids Res. | pmid:17999998 |
| Schäfer S et al. | Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). | 2008 | Bioorg. Med. Chem. | pmid:18054239 |
| Politis PK et al. | BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells. | 2008 | FEBS Lett. | pmid:18258204 |
| Isakov E et al. | Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica. | 2008 | Mol. Biochem. Parasitol. | pmid:18191469 |
| Andrews KT et al. | Potent antimalarial activity of histone deacetylase inhibitor analogues. | 2008 | Antimicrob. Agents Chemother. | pmid:18212103 |
| Kimata Y et al. | Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. | 2008 | J. Cell. Sci. | pmid:18354085 |
| Suuronen T et al. | Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90. | 2008 | Neurochem. Res. | pmid:18307035 |
| Jiang Y et al. | Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes. | 2008 | J. Exp. Biol. | pmid:18310117 |
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| Nakao Y et al. | Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18397826 |
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| Yang YN et al. | [Effects of trichostatin A and paclitaxel on apoptosis and mitochondrial membrane potential of human endometrial carcinoma Ark2 cells]. | 2008 | Ai Zheng | pmid:18710614 |
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| Donadelli M et al. | Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. | 2007 | Biochim. Biophys. Acta | pmid:17555830 |
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| Piotrowska H and Jagodzinski PP | Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. | 2007 | Biomed. Pharmacother. | pmid:17498915 |
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