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Monaldi Arch Chest Dis |
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Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. |
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Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). |
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Cell biology: Tubulin acetylation and cell motility. |
2003 |
Nature |
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2003 |
Mol. Cell |
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Maintenance of stable heterochromatin domains by dynamic HP1 binding. |
2003 |
Science |
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2003 |
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The effect of oxidative stress on histone acetylation and IL-8 release. |
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RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. |
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Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. |
2003 |
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Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. |
2003 |
Blood |
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Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. |
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The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. |
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Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. |
2003 |
Mol. Cell. Biol. |
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Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. |
2003 |
Cancer Res. |
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Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. |
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The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. |
2003 |
Ann. N. Y. Acad. Sci. |
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Transcription-coupled events associating with immunoglobulin switch region chromatin. |
2003 |
Science |
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Small molecule modulation of the human chromatid decatenation checkpoint. |
2003 |
Chem. Biol. |
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Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. |
2003 |
J. Med. Chem. |
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Expression of P53, P21 in human lung adenocarcinoma A549 cell strains under hypoxia conditions and the effect of TSA on their expression. |
2003 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
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Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. |
2003 |
Clin. Cancer Res. |
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Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. |
2003 |
Cancer Res. |
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Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes. |
2003 |
J. Hepatol. |
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Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. |
2003 |
J. Biol. Chem. |
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Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation. |
2003 |
Oncogene |
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Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation. |
2003 |
Recent Results Cancer Res. |
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Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. |
2003 |
Toxicol. Appl. Pharmacol. |
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Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation. |
2003 |
Oncogene |
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Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma. |
2003 |
Biochem. Biophys. Res. Commun. |
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Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. |
2003 |
J. Biol. Chem. |
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Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B. |
2003 |
Mol. Cell. Biol. |
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Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. |
2003 |
Mol. Cell. Biol. |
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Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. |
2003 |
Oncogene |
pmid:12917630
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A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12886011
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Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. |
2003 |
Nucleic Acids Res. |
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2003 |
Mol. Cell. Biol. |
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Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. |
2003 |
Carcinogenesis |
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Acetylated sp3 is a transcriptional activator. |
2003 |
J. Biol. Chem. |
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Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen. |
2003 |
J. Immunol. |
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SHP-1 sensitizes MCF-7 cells to trichostatin A-induced apoptosis by modulating PI3K-dependent events. |
2003 |
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Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells. |
2003 |
Mol. Carcinog. |
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MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. |
2003 |
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Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. |
2003 |
Int. J. Cancer |
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Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. |
2003 |
Nucleic Acids Res. Suppl. |
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Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. |
2003 |
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2003 |
Pharmacol. Res. |
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Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. |
2003 |
Chem. Biol. |
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Repressors of androgen and progesterone receptor action. |
2003 |
J. Biol. Chem. |
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Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. |
2003 |
Int. J. Cancer |
pmid:12640681
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The thyroid hormone receptor antagonizes CREB-mediated transcription. |
2003 |
EMBO J. |
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Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression. |
2003 |
Circ. Res. |
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Bhakat KK and Mitra S |
CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. |
2003 |
Carcinogenesis |
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Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. |
2003 |
Biochem. Biophys. Res. Commun. |
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Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. |
2003 |
Cancer Res. |
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Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. |
2003 |
Oncogene |
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Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. |
2003 |
Oncogene |
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Changes in histone acetylation during mouse oocyte meiosis. |
2003 |
J. Cell Biol. |
pmid:12835313
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Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. |
2003 |
Nucleic Acids Res. |
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Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. |
2003 |
Biochem. Biophys. Res. Commun. |
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Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12788094
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Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. |
2003 |
Oncogene |
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Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter. |
2003 |
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The SV40 T antigen modulates CBP histone acetyltransferase activity. |
2003 |
Nucleic Acids Res. |
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Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. |
2003 |
Oncogene |
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Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. |
2003 |
Nucleic Acids Res. |
pmid:12799440
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Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. |
2003 |
Cancer Res. |
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Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. |
2003 |
J. Med. Chem. |
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p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. |
2003 |
Exp. Hematol. |
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Role of promoter methylation in regulation of the mammalian heparanase gene. |
2003 |
Oncogene |
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p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. |
2003 |
Oncogene |
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Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. |
2003 |
Int. J. Mol. Med. |
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Ab initio study of the binding of Trichostatin A (TSA) in the active site of histone deacetylase like protein (HDLP). |
2003 |
Org. Biomol. Chem. |
pmid:12968347
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[HDAC1 expression and effect of TSA on proliferation and apoptosis of A549 cells]. |
2003 |
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Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas. |
2003 |
Cancer Lett. |
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Deacetylase activity is required for cAMP activation of a subset of CREB target genes. |
2003 |
J. Biol. Chem. |
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A composite motif of the Drosophila morphogenetic protein bicoid critical to transcription control. |
2003 |
J. Biol. Chem. |
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Silencing of CDX2 expression in colon cancer via a dominant repression pathway. |
2003 |
J. Biol. Chem. |
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Epigenetic assembly of centromeric chromatin at ectopic alpha-satellite sites on human chromosomes. |
2003 |
J. Cell. Sci. |
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Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. |
2003 |
Nucleic Acids Res. |
pmid:12954772
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Brugarolas JB et al. |
TSC2 regulates VEGF through mTOR-dependent and -independent pathways. |
2003 |
Cancer Cell |
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Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. |
2003 |
Mol. Biol. Cell |
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Autoregulation of mouse histone deacetylase 1 expression. |
2003 |
Mol. Cell. Biol. |
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The histone code regulating expression of the imprinted mouse Igf2r gene. |
2003 |
Endocrinology |
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Identification of novel isoform-selective inhibitors within class I histone deacetylases. |
2003 |
J. Pharmacol. Exp. Ther. |
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Centromeric chromatin pliability and memory at a human neocentromere. |
2003 |
EMBO J. |
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Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. |
2003 |
Biol. Reprod. |
pmid:12748129
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Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. |
2003 |
Bioorg. Med. Chem. Lett. |
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Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. |
2003 |
Cancer Res. |
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Histone acetylation-mediated regulation of genes in leukaemic cells. |
2003 |
Eur. J. Cancer |
pmid:12736119
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The mechanism of 3'-azido-2',3'-dideoxythymidine resistance to human lymphoid cells. |
2003 |
Int. J. Mol. Med. |
pmid:12736716
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Valenta T et al. |
HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. |
2003 |
Nucleic Acids Res. |
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PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. |
2003 |
J. Biol. Chem. |
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Upregulation of activin A gene by butyrate in human colon cancer cell lines. |
2003 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:12540370
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Kagoshima M et al. |
Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. |
2003 |
Biochem. Soc. Trans. |
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Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. |
2003 |
Plant J. |
pmid:12581304
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Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. |
2003 |
Plant J. |
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Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. |
2003 |
J. Med. Chem. |
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Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. |
2003 |
Int. J. Cancer |
pmid:12594812
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Teyssier C et al. |
Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. |
2003 |
Mol. Endocrinol. |
pmid:12554755
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