| MeSH term | MeSH ID | Detail |
|---|---|---|
| Enteritis | D004751 | 8 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Immunologic Deficiency Syndromes | D007153 | 8 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Biliary Tract Neoplasms | D001661 | 7 associated lipids |
| Cytomegalovirus Infections | D003586 | 7 associated lipids |
| Carcinoma, Pancreatic Ductal | D021441 | 6 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Leukemia, Myelomonocytic, Acute | D015479 | 6 associated lipids |
| Polycystic Kidney, Autosomal Dominant | D016891 | 6 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tomita K et al. | The effect of oxidative stress on histone acetylation and IL-8 release. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565901 |
| Tong X et al. | Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15063780 |
| Bai L and Merchant JL | ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17560543 |
| Takechi S et al. | Chicken HDAC2 down-regulates IgM light chain gene promoter activity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437980 |
| Kitamoto S et al. | Promoter hypomethylation contributes to the expression of MUC3A in cancer cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20510874 |
| Sakata R et al. | Trichostatin A activates the osteopontin gene promoter through AP1 site. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14985105 |
| Steiner E et al. | SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047174 |
| Togi S et al. | HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19121623 |
| Nan X et al. | Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15465025 |
| Jang SM et al. | Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916609 |
| Harada Y et al. | A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11396961 |
| Nagaraja SS et al. | Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549Â cells. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28993195 |
| Sowa Y et al. | Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9405248 |
| Nadanaka S et al. | Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751852 |
| Hu JF et al. | The role of histone acetylation in the allelic expression of the imprinted human insulin-like growth factor II gene. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792787 |
| Korhonen P et al. | Expression of transcriptional repressor protein mSin3A but not mSin3B is induced during neuronal apoptosis. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9813182 |
| Park KK et al. | Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788094 |
| Noh H et al. | Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26768368 |
| Oshima M et al. | Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17949687 |
| Liu J et al. | Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086099 |