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The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. |
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Oncogene |
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The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. |
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Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. |
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Clin. Cancer Res. |
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Cancer Res. |
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A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
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Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. |
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Nucleic Acids Res. |
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Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. |
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Carcinogenesis |
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Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. |
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Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. |
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Int. J. Cancer |
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Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. |
2003 |
Oncogene |
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Nucleic Acids Res. |
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Nucleic Acids Res. |
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Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. |
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Nucleic Acids Res. |
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The histone code regulating expression of the imprinted mouse Igf2r gene. |
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Endocrinology |
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Identification of novel isoform-selective inhibitors within class I histone deacetylases. |
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J. Pharmacol. Exp. Ther. |
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EMBO J. |
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Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. |
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Biol. Reprod. |
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Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. |
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Bioorg. Med. Chem. Lett. |
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Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. |
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Cancer Res. |
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Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. |
2003 |
Gut |
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Generation of hepatocyte-like cells from human embryonic stem cells. |
2003 |
Cell Transplant |
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