trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Medulloblastoma D008527 22 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Banwell CM et al. Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors. 2004 J. Steroid Biochem. Mol. Biol. pmid:15225779
Fang JY et al. Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116. 2004 Cell Res. pmid:15225415
Sumer H et al. Effects of scaffold/matrix alteration on centromeric function and gene expression. 2004 J. Biol. Chem. pmid:15220334
Jia S et al. RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. 2004 Science pmid:15218150
Ishihara K et al. Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils. 2004 Br. J. Pharmacol. pmid:15210580
Korzus E et al. CBP histone acetyltransferase activity is a critical component of memory consolidation. 2004 Neuron pmid:15207240
Min KN et al. Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. 2004 Arch. Pharm. Res. pmid:15202563
Moldenhauer A et al. Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins. 2004 J. Leukoc. Biol. pmid:15197237
Lu H et al. Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. 2004 J. Virol. pmid:15194748
Ng Y et al. Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. 2004 J. Biol. Chem. pmid:15194684
Sakamoto S et al. Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. 2004 J. Biol. Chem. pmid:15194680
Brieger A et al. In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. 2004 Biochem. Pharmacol. pmid:15183120
Ishiguro K and Sartorelli AC Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. 2004 Eur. J. Biochem. pmid:15182353
Vanhaecke T et al. Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. 2004 Curr. Med. Chem. pmid:15180568
Ahn MR et al. Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. 2004 Arch. Pharm. Res. pmid:15180307
Flørenes VA et al. Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. 2004 Melanoma Res. pmid:15179185
Lee YJ et al. Mechanism of transcriptional repression by TEL/RUNX1 fusion protein. 2004 Mol. Cells pmid:15179033
Zhang X et al. Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. 2004 Mol. Cell. Biol. pmid:15169878
Ronai D et al. The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature. 2004 Genetics pmid:15166165
Glenn MP et al. Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. 2004 J. Med. Chem. pmid:15163181
Zhang Y et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. 2004 Radiat. Res. pmid:15161353
Wang LG et al. Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. 2004 Oncogene pmid:15156193
Zoumpoulidou G et al. Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). 2004 Mol. Endocrinol. pmid:15155784
Kato N et al. Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. 2004 Cell Death Differ. pmid:15153943
Kim YH et al. Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. 2004 Carcinogenesis pmid:15142888
Kurtev V et al. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. 2004 J. Biol. Chem. pmid:15140878
Jin YH et al. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. 2004 J. Biol. Chem. pmid:15138260
Winn RA and Heasley LE Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. 2004 Chest pmid:15136458
Ishii S et al. Aberrant dynamics of histone deacetylation at the thyrotropin-releasing hormone gene in resistance to thyroid hormone. 2004 Mol. Endocrinol. pmid:15131262
Bort R et al. Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. 2004 Arch. Biochem. Biophys. pmid:15130783
Iezzi S et al. Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin. 2004 Dev. Cell pmid:15130492
Phan D et al. Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. 2004 Cancer Res. pmid:15126343
Fu M et al. The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. 2004 J. Biol. Chem. pmid:15123687
Klampfer L et al. Requirement of histone deacetylase activity for signaling by STAT1. 2004 J. Biol. Chem. pmid:15123634
Mizukami T et al. Effects of trichostatin a, a histone deacetylase inhibitor, on mouse gonadal development in vitro. 2004 J. Reprod. Dev. pmid:15118250
Arapshian A et al. Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. 2004 Mol. Cancer pmid:15113415
Marson CM et al. Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. 2004 Bioorg. Med. Chem. Lett. pmid:15109636
Nishino N et al. Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. 2004 Bioorg. Med. Chem. Lett. pmid:15109626
McGarry LC et al. Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes. 2004 Oncogene pmid:15107823
Yokota T et al. Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. 2004 Oncogene pmid:15107822
Lasa A et al. MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. 2004 Leukemia pmid:15103390
Jansen MS et al. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15103026
Tani M et al. Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells. 2004 Genes Chromosomes Cancer pmid:15101048
Munro J et al. Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. 2004 Exp. Cell Res. pmid:15093749
Chang HC et al. Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. 2004 Cell. Signal. pmid:15093608
Milutinovic S et al. DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation. 2004 J. Biol. Chem. pmid:15087453
Amor DJ et al. Human centromere repositioning "in progress". 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15084747
Ahmed S et al. A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast. 2004 Mol. Cell. Biol. pmid:15082762
Romanski A et al. Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. 2004 Haematologica pmid:15075075
Margueron R et al. Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. 2004 J. Mol. Endocrinol. pmid:15072561
Ganslmayer M et al. A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. 2004 Oncol. Rep. pmid:15069530
Tong X et al. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. 2004 Biochem. Biophys. Res. Commun. pmid:15063780
Vorontsova M et al. Effect of 5-azacytidine and trichostatin A on somatic centromere association in wheat. 2004 Genome pmid:15060593
Hildmann C et al. A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. 2004 J. Bacteriol. pmid:15060035
Chen YX et al. [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. 2004 Zhonghua Yi Xue Za Zhi pmid:15059516
Kypreou KP et al. Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A. 2004 Exp. Gerontol. pmid:15050280
Steiner E et al. SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. 2004 Biochem. Biophys. Res. Commun. pmid:15047174
Liu X et al. Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. 2004 Biochem. Pharmacol. pmid:15041467
David GL et al. MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine. 2004 Cancer Biol. Ther. pmid:15034303
Burton GR et al. Microarray analysis of differentiation-specific gene expression during 3T3-L1 adipogenesis. 2004 Gene pmid:15033539
Chung YL et al. Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy. 2004 Mol. Cancer Ther. pmid:15026552
Knobbe CB et al. Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. 2004 J. Natl. Cancer Inst. pmid:15026474
Aapola U et al. Epigenetic modifications affect Dnmt3L expression. 2004 Biochem. J. pmid:15015937
Huang H et al. Expression of P53, P21 in human lung adenocarcinoma A549 cell strains under hypoxia conditions and the effect of TSA on their expression. 2003 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:15015635
Gray SG et al. Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. 2004 Int. J. Oncol. pmid:15010814
Astrand C et al. Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure. 2004 Eur. J. Biochem. pmid:15009194
Hwang CK et al. Transcriptional regulation of mouse mu opioid receptor gene by PU.1. 2004 J. Biol. Chem. pmid:14998994
Ragno R et al. 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. 2004 J. Med. Chem. pmid:14998325
Khan AN et al. An epigenetically altered tumor cell vaccine. 2004 Cancer Immunol. Immunother. pmid:14997346
Chua YL et al. Microarray analysis of chromatin-immunoprecipitated DNA identifies specific regions of tobacco genes associated with acetylated histones. 2004 Plant J. pmid:14996214
Nojima H et al. Increase in DNA methylation downregulates conceptus interferon-tau gene expression. 2004 Mol. Reprod. Dev. pmid:14991730
Lu XC et al. [Effect of inhibitors for demethylation and histone deacetylase on proliferation of cell line K562 and expression of tumor related genes]. 2004 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:14989767
Sakata R et al. Trichostatin A activates the osteopontin gene promoter through AP1 site. 2004 Biochem. Biophys. Res. Commun. pmid:14985105
Agostinho M et al. Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis. 2004 Mol. Biol. Cell pmid:14978217
Milhem M et al. Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A. 2004 Blood pmid:14976039
Mai A et al. 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. 2004 J. Med. Chem. pmid:14971890
Reifenberger J et al. Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. 2004 Int. J. Cancer pmid:14961576
Takai N et al. Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. 2004 Clin. Cancer Res. pmid:14871994
García I et al. Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. 2004 Eukaryotic Cell pmid:14871945
Um SJ et al. In vitro antitumor potential of 4-BPRE, a butyryl aminophenyl ester of retinoic acid: role of the butyryl group. 2004 Oncol. Rep. pmid:14767528
Hattori N et al. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. 2004 J. Biol. Chem. pmid:14761969
Lemonde S et al. Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. 2004 J. Neurochem. pmid:14756806
Lee JH et al. Histone deacetylase activity is required for embryonic stem cell differentiation. 2004 Genesis pmid:14755802
Parekh-Olmedo H et al. The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. 2003 Ann. N. Y. Acad. Sci. pmid:14751821
Wang DF et al. QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids. 2004 Bioorg. Med. Chem. Lett. pmid:14741273
Nishikawa J et al. Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line. 2004 Virus Genes pmid:14739656
Christian M et al. Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. 2004 J. Biol. Chem. pmid:14736873
Sugimoto S et al. Expression and regulation of tumor suppressor gene maspin in human bladder cancer. 2004 Cancer Lett. pmid:14732229
Yan C et al. A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. 2004 FASEB J. pmid:14715692
Pagans S et al. Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. 2004 J. Biol. Chem. pmid:14701830
Haggarty SJ et al. Small molecule modulation of the human chromatid decatenation checkpoint. 2003 Chem. Biol. pmid:14700634
Leu TH et al. Participation of p97Eps8 in Src-mediated transformation. 2004 J. Biol. Chem. pmid:14699156
Terui T et al. Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. 2003 Cancer Res. pmid:14695212
Obata T et al. Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. 2003 Clin. Cancer Res. pmid:14695142
Nambu Y et al. Transcription-coupled events associating with immunoglobulin switch region chromatin. 2003 Science pmid:14684824
Vaisburg A et al. (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. 2004 Bioorg. Med. Chem. Lett. pmid:14684344
Jang ER et al. The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen. 2004 Oncogene pmid:14676837
Brush MH et al. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 2004 J. Biol. Chem. pmid:14670976
Kim DK et al. Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. 2003 J. Med. Chem. pmid:14667227
Shim JS et al. Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. 2004 Oncogene pmid:14661058