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Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. |
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Zygote |
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Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. |
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ACS Med Chem Lett |
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Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. |
2011 |
Physiol. Genomics |
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Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. |
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Int. J. Cancer |
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Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. |
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Int. J. Cancer |
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Circ. Res. |
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Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. |
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Biochem. Biophys. Res. Commun. |
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J. Assist. Reprod. Genet. |
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HDAC activity is required during Xenopus tail regeneration. |
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PLoS ONE |
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2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. |
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[The effects of a histone deacetylase (HDAC) inhibitor on endotoxin-induced endothelial cell injury]. |
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PLoS ONE |
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Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. |
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Eur J Nutr |
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Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. |
2011 |
Eur J Med Chem |
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2011 |
Cell Biol. Int. |
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Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. |
2011 |
Theriogenology |
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Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. |
2011 |
Theriogenology |
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Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. |
2011 |
Neuro Endocrinol. Lett. |
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HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. |
2011 |
Ann. N. Y. Acad. Sci. |
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Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. |
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Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. |
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J Thorac Oncol |
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SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. |
2011 |
BMC Cancer |
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Structure-based optimization of click-based histone deacetylase inhibitors. |
2011 |
Eur J Med Chem |
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Valproic acid phase shifts the rhythmic expression of Period2::Luciferase. |
2011 |
J. Biol. Rhythms |
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The histone acetyltransferase p300 promotes intrinsic axonal regeneration. |
2011 |
Brain |
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p53 in trichostatin A induced C6 glioma cell death. |
2011 |
Biochim. Biophys. Acta |
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Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells. |
2011 |
J. Biomed. Biotechnol. |
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Photosensitization by iodinated DNA minor groove binding ligands: Evaluation of DNA double-strand break induction and repair. |
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J. Photochem. Photobiol. B, Biol. |
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Classical Hodgkin's lymphoma shows epigenetic features of abortive plasma cell differentiation. |
2011 |
Haematologica |
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Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). |
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Alcohol. Clin. Exp. Res. |
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ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. |
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Toxicon |
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[Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. |
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Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. |
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Arch. Dermatol. Res. |
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Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. |
2011 |
Endocrinology |
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Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. |
2011 |
PLoS ONE |
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Epigenetic inactivation of PCDH10 in human prostate cancer cell lines. |
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Cell Biol. Int. |
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HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). |
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Neurochem. Int. |
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Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. |
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Cancer Invest. |
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DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. |
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J. Biol. Chem. |
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Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. |
2011 |
PLoS ONE |
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Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. |
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Mod. Pathol. |
pmid:21317879
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Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. |
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J. Clin. Immunol. |
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Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. |
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Int. J. Oncol. |
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Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment. |
2011 |
Differentiation |
pmid:21306817
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Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. |
2011 |
Hepatology |
pmid:21319187
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Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. |
2011 |
Toxicol In Vitro |
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Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. |
2011 |
Cancer Res. |
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Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. |
2011 |
J Negat Results Biomed |
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Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation. |
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Oncogene |
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PTTG1 attenuates drug-induced cellular senescence. |
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PLoS ONE |
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Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. |
2011 |
Biol. Reprod. |
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Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. |
2011 |
Int. J. Oncol. |
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Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer. |
2011 |
Breast Cancer Res. Treat. |
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Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: roles of epigenetic modifications in transcriptional regulation. |
2011 |
Mol. Cell. Endocrinol. |
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Wang Y et al. |
The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. |
2011 |
Cell Reprogram |
pmid:21486115
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p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. |
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J. Cell. Sci. |
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Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. |
2011 |
Cancer Sci. |
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Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. |
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Physiol. Behav. |
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Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. |
2011 |
Epigenetics |
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Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. |
2011 |
J. Cell. Biochem. |
pmid:21465530
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Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. |
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Curr Cancer Drug Targets |
pmid:21762083
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Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. |
2011 |
J. Cell. Biochem. |
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Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. |
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FEBS Lett. |
pmid:21763693
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Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. |
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J Toxicol Sci |
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Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. |
2011 |
Apoptosis |
pmid:21468663
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Hu Y et al. |
Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. |
2011 |
PLoS ONE |
pmid:21811564
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Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. |
2011 |
Spine |
pmid:21343850
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Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos. |
2011 |
J. Reprod. Dev. |
pmid:20834196
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Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. |
2011 |
PLoS ONE |
pmid:21789245
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Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. |
2011 |
Mol. Cell. Biol. |
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Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. |
2011 |
PLoS ONE |
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Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. |
2011 |
Am. J. Respir. Crit. Care Med. |
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Somatic cell-induced hyperacetylation, but not hypomethylation, positively and reversibly affects the efficiency of in vitro cloned blastocyst production in cattle. |
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Cell Reprogram |
pmid:21919704
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Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment. |
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Cancer Sci. |
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[Effect of trichostatin alone and combination with imatinb on the proliferation and apoptosis of the K562R cells]. |
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Zhong Nan Da Xue Xue Bao Yi Xue Ban |
pmid:21937807
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Cai HH et al. |
Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. |
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HBPD INT |
pmid:21269942
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HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. |
2011 |
J. Biomed. Biotechnol. |
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Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. |
2011 |
Rheumatol. Int. |
pmid:20390279
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The histone deacetylase inhibitor trichostatin A synergistically resensitizes a cisplatin resistant human bladder cancer cell line. |
2011 |
J. Urol. |
pmid:21255805
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Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. |
2011 |
Bioorg. Med. Chem. Lett. |
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Inhibition of histone deacetylase causes emphysema. |
2011 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:21224215
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Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. |
2011 |
Cell Reprogram |
pmid:21241188
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Nakamura J et al. |
Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. |
2011 |
Am. J. Pathol. |
pmid:21281785
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Puppin C et al. |
In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription. |
2011 |
Cell Oncol (Dordr) |
pmid:21290209
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Chen MY et al. |
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. |
2011 |
Cancer |
pmid:21491416
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Chakravarty G et al. |
Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. |
2011 |
Cancer Biol. Ther. |
pmid:21084857
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Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma. |
2011 |
Dig. Dis. Sci. |
pmid:21567192
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Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines. |
2011 |
Oncol. Rep. |
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Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. |
2011 |
Cell Death Differ. |
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Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract. |
2011 |
Hum. Cell |
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Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. |
2011 |
J. Med. Chem. |
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Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A. |
2011 |
Cell Reprogram |
pmid:21548828
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Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. |
2011 |
Cell. Mol. Life Sci. |
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Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. |
2011 |
Arthritis Res. Ther. |
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Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. |
2011 |
J Thorac Oncol |
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