| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Vulgaris | D008177 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu TC et al. | Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22626855 |
| Dar RD et al. | Transcriptional burst frequency and burst size are equally modulated across the human genome. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23064634 |
| Cho JS et al. | Epigenetic regulation of myofibroblast differentiation and extracellular matrix production in nasal polyp-derived fibroblasts. | 2012 | Clin. Exp. Allergy | pmid:22239687 |
| Shen YC et al. | The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. | 2012 | Dev. Biol. | pmid:22210003 |
| Huang D et al. | A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study. | 2012 | Eur J Med Chem | pmid:22465091 |
| SustáÄková G et al. | Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. | 2012 | J. Cell. Physiol. | pmid:21732356 |
| Nepelska M et al. | Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. | 2012 | PLoS ONE | pmid:23300800 |
| Mostovich LA et al. | Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. | 2011 Sep-Oct | Cell Adh Migr | pmid:21975548 |
| Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
| Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
| Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
| Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
| Bo F et al. | Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. | 2011 | Zygote | pmid:20569515 |
| Majumdar G et al. | Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. | 2011 | Physiol. Genomics | pmid:21954451 |
| Hirata H et al. | Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. | 2011 | Int. J. Cancer | pmid:20549706 |
| Tsai KW et al. | Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. | 2011 | Int. J. Cancer | pmid:21960261 |
| Ohtani K et al. | Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. | 2011 | Circ. Res. | pmid:21980126 |
| Hagiwara H et al. | Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22019851 |
| Jafari S et al. | Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos. | 2011 | J. Assist. Reprod. Genet. | pmid:22020531 |
| Tseng AS et al. | HDAC activity is required during Xenopus tail regeneration. | 2011 | PLoS ONE | pmid:22022609 |
| Rajak H et al. | 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21875796 |
| He HM et al. | [The effects of a histone deacetylase (HDAC) inhibitor on endotoxin-induced endothelial cell injury]. | 2011 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22005560 |
| Kaichi S et al. | Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. | 2011 | J. Cell. Physiol. | pmid:20665673 |
| Marrazzo A et al. | Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. | 2011 | Eur J Med Chem | pmid:21055848 |
| Gao A et al. | Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression. | 2011 | Cell Biol. Int. | pmid:21143203 |
| Wang YS et al. | Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. | 2011 | Theriogenology | pmid:21144561 |
| Shiratsuki S et al. | Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. | 2011 | Theriogenology | pmid:21144563 |
| Xia B et al. | Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. | 2011 | Toxicol. Lett. | pmid:21641978 |
| Seo SK et al. | Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. | 2011 | J Thorac Oncol | pmid:21642861 |
| Acun T et al. | SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. | 2011 | BMC Cancer | pmid:21645397 |
| Hou J et al. | Structure-based optimization of click-based histone deacetylase inhibitors. | 2011 | Eur J Med Chem | pmid:21621883 |
| Johansson AS et al. | Valproic acid phase shifts the rhythmic expression of Period2::Luciferase. | 2011 | J. Biol. Rhythms | pmid:22215612 |
| Gaub P et al. | The histone acetyltransferase p300 promotes intrinsic axonal regeneration. | 2011 | Brain | pmid:21705428 |
| Song K et al. | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. | 2011 | Cancer Biol. Ther. | pmid:21709440 |
| Hauff KD et al. | Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1. | 2011 | Lipids | pmid:21710238 |
| Zhang Y et al. | ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. | 2011 | Toxicon | pmid:21419152 |
| WEI Q et al. | [Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:21421475 |
| Jergil M et al. | Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. | 2011 | Toxicol. Sci. | pmid:21427059 |
| Diao JS et al. | Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. | 2011 | Arch. Dermatol. Res. | pmid:21400246 |
| Zhang J et al. | Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. | 2011 | Endocrinology | pmid:21406501 |
| Kawasaki H et al. | Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. | 2011 | PLoS ONE | pmid:21407806 |
| Li Z et al. | Epigenetic inactivation of PCDH10 in human prostate cancer cell lines. | 2011 | Cell Biol. Int. | pmid:21314642 |
| Saiyed ZM et al. | HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). | 2011 | Neurochem. Int. | pmid:21315782 |
| Fang Y et al. | Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. | 2011 | Cancer Invest. | pmid:21345073 |
| Qian Y et al. | DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. | 2011 | J. Biol. Chem. | pmid:21317427 |
| Zhang F et al. | Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. | 2011 | PLoS ONE | pmid:21346816 |
| Hizaki K et al. | Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. | 2011 | Mod. Pathol. | pmid:21317879 |
| Zhou X et al. | Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. | 2011 | J. Clin. Immunol. | pmid:21305388 |
| Meli M et al. | Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. | 2011 | Int. J. Oncol. | pmid:21318222 |
| Turovets N et al. | Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment. | 2011 | Differentiation | pmid:21306817 |
| Xiao J et al. | Discovery, synthesis, and biological evaluation of novel SMN protein modulators. | 2011 | J. Med. Chem. | pmid:21819082 |
| Yang H et al. | Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. | 2011 | Hepatology | pmid:21319187 |
| Patel T et al. | Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. | 2011 | Immunol. Cell Biol. | pmid:21321581 |
| Chaurasia P et al. | Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. | 2011 | Blood | pmid:21355088 |
| Shi G et al. | The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells. | 2011 | J. Cell. Physiol. | pmid:21321941 |
| Furuta K et al. | The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. | 2011 | Plant Cell Physiol. | pmid:21357580 |
| Fortson WS et al. | Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. | 2011 | Int. J. Oncol. | pmid:21519790 |
| Inoue H et al. | Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: roles of epigenetic modifications in transcriptional regulation. | 2011 | Mol. Cell. Endocrinol. | pmid:21756973 |
| Wang Y et al. | The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. | 2011 | Cell Reprogram | pmid:21486115 |
| Watanabe Y and Tanaka M | p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. | 2011 | J. Cell. Sci. | pmid:21771882 |
| Hattori N et al. | Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. | 2011 | Cancer Sci. | pmid:21489049 |
| Miller L et al. | Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. | 2011 | Physiol. Behav. | pmid:21463644 |
| Tost J et al. | Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. | 2011 | Epigenetics | pmid:21775817 |
| Law AY et al. | Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. | 2011 | J. Cell. Biochem. | pmid:21465530 |
| Blanquart C et al. | Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. | 2011 | Curr Cancer Drug Targets | pmid:21762083 |
| Pang M et al. | Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. | 2011 | J. Cell. Biochem. | pmid:21465537 |
| Wan Y et al. | Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. | 2011 | FEBS Lett. | pmid:21763693 |
| Kimura T et al. | Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. | 2011 | J Toxicol Sci | pmid:21467744 |
| Zhang CZ et al. | Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. | 2011 | Apoptosis | pmid:21468663 |
| Hu Y et al. | Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. | 2011 | PLoS ONE | pmid:21811564 |
| Chen YT et al. | Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. | 2011 | Spine | pmid:21343850 |
| Lee MJ et al. | Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos. | 2011 | J. Reprod. Dev. | pmid:20834196 |
| Amoêdo ND et al. | Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. | 2011 | PLoS ONE | pmid:21789245 |
| Sengupta S et al. | Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. | 2011 | Oncogene | pmid:20856196 |
| Arzenani MK et al. | Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. | 2011 | Mol. Cell. Biol. | pmid:21791605 |
| Costa VL et al. | TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. | 2011 | Epigenetics | pmid:21847011 |
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| Cai HH et al. | Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. | 2011 | HBPD INT | pmid:21269942 |
| Lee SC et al. | HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. | 2011 | J. Biomed. Biotechnol. | pmid:21253530 |
| Chen WP et al. | Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. | 2011 | Rheumatol. Int. | pmid:20390279 |
| Yoon CY et al. | The histone deacetylase inhibitor trichostatin A synergistically resensitizes a cisplatin resistant human bladder cancer cell line. | 2011 | J. Urol. | pmid:21255805 |
| Choi E et al. | Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21256006 |
| Mizuno S et al. | Inhibition of histone deacetylase causes emphysema. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21224215 |
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| Nakamura J et al. | Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. | 2011 | Am. J. Pathol. | pmid:21281785 |
| Puppin C et al. | In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription. | 2011 | Cell Oncol (Dordr) | pmid:21290209 |
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| Ma AN et al. | Histone deacetylation directs DNA methylation in survivin gene silencing. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21130077 |
| Pianta A et al. | Nucleophosmin delocalization in thyroid tumour cells. | 2011 | Endocr. Pathol. | pmid:21258971 |
| Gómez MC et al. | Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. | 2011 | Cell Reprogram | pmid:21718106 |
| Whitehead L et al. | Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. | 2011 | Bioorg. Med. Chem. | pmid:21723733 |
| Puppin C et al. | Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines. | 2011 | Oncol. Rep. | pmid:21617864 |
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| Vojdani Z et al. | Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract. | 2011 | Hum. Cell | pmid:21547694 |
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| Ververis K et al. | Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. | 2011 | Cell. Mol. Life Sci. | pmid:21584806 |
| Misaki K et al. | Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. | 2011 | Arthritis Res. Ther. | pmid:21592365 |
| Selinger CI et al. | Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. | 2011 | J Thorac Oncol | pmid:21597389 |