| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Vulgaris | D008177 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nordström L et al. | DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. | 2015 | BMC Cancer | pmid:25880212 |
| Tong JH et al. | Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. | 2010 | BMC Cancer | pmid:20525238 |
| Moreira JM et al. | The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. | 2003 | BMC Cancer | pmid:14606959 |
| Dávalos-Salas M et al. | Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. | 2011 | BMC Cancer | pmid:21663659 |
| Place RF et al. | HDACs and the senescent phenotype of WI-38 cells. | 2005 | BMC Cell Biol. | pmid:16250917 |
| Snykers S et al. | Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. | 2007 | BMC Dev. Biol. | pmid:17407549 |
| Kan R et al. | Potential role for PADI-mediated histone citrullination in preimplantation development. | 2012 | BMC Dev. Biol. | pmid:22712504 |
| Chen B and Cepko CL | Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. | 2007 | BMC Dev. Biol. | pmid:17603891 |
| Hou J et al. | Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation. | 2008 | BMC Dev. Biol. | pmid:18507869 |
| Maalouf WE et al. | Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term. | 2009 | BMC Dev. Biol. | pmid:19210795 |
| Lee TB et al. | Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. | 2008 | BMC Gastroenterol | pmid:18673531 |
| Hedberg Oldfors C et al. | Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. | 2015 | BMC Genet. | pmid:26170120 |
| Wu J et al. | Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing. | 2007 | BMC Genomics | pmid:17524140 |
| Chittur SV et al. | Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | 2008 | BMC Genomics | pmid:18959802 |
| Aseem O et al. | Cubilin expression is monoallelic and epigenetically augmented via PPARs. | 2013 | BMC Genomics | pmid:23773363 |
| Ehrenkaufer GM et al. | Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. | 2007 | BMC Genomics | pmid:17612405 |
| Scholl C et al. | Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain. | 2012 | BMC Genomics | pmid:22748179 |
| Majumdar G et al. | Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. | 2012 | BMC Genomics | pmid:23249388 |
| Ma X et al. | Identification of genes regulated by histone acetylation during root development in Populus trichocarpa. | 2016 | BMC Genomics | pmid:26847576 |
| Hosseini SM et al. | Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. | 2016 | BMC Genomics | pmid:26725231 |
| Dannenberg LO and Edenberg HJ | Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. | 2006 | BMC Genomics | pmid:16854234 |
| Ferreira R et al. | Site-specific acetylation of ISWI by GCN5. | 2007 | BMC Mol. Biol. | pmid:17760996 |
| Balaguer TM et al. | Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines. | 2012 | BMC Mol. Biol. | pmid:22846052 |
| Gaviraghi M et al. | Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene. | 2008 | BMC Mol. Biol. | pmid:18549468 |
| Chandler SP et al. | Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. | 2003 | BMC Mol. Biol. | pmid:12659659 |
| Marshall H et al. | Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice. | 2010 | BMC Mol. Biol. | pmid:20429939 |
| Mercer TR et al. | Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. | 2010 | BMC Neurosci | pmid:20137068 |
| Bieluszewski T et al. | AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. | 2015 | BMC Plant Biol. | pmid:25849764 |
| Yang F et al. | Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize. | 2010 | BMC Plant Biol. | pmid:20718950 |
| Huynh NC et al. | Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells. | 2017 | Bone | pmid:27871909 |
| Truong M et al. | Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence. | 2012 | Br. J. Cancer | pmid:22596233 |
| Meng F et al. | Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. | 2013 | Br. J. Cancer | pmid:23370212 |
| Zaman MS et al. | The functional significance of microRNA-145 in prostate cancer. | 2010 | Br. J. Cancer | pmid:20588276 |
| Ridolfi E et al. | Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. | 2008 | Br. J. Cancer | pmid:18941460 |
| El-Khoury V et al. | The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model. | 2007 | Br. J. Cancer | pmid:17667922 |
| Yamada N et al. | Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. | 2009 | Br. J. Cancer | pmid:19127263 |
| Chang J et al. | Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. | 2012 | Br. J. Cancer | pmid:22158273 |
| Frame FM et al. | HDAC inhibitor confers radiosensitivity to prostate stem-like cells. | 2013 | Br. J. Cancer | pmid:24220693 |
| Moreaux J et al. | Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors. | 2013 | Br. J. Cancer | pmid:23868005 |
| Carén H et al. | Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. | 2007 | Br. J. Cancer | pmid:17940511 |
| Dote H et al. | Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. | 2005 | Br. J. Cancer | pmid:15770214 |
| Yasukawa K et al. | Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts. | 2007 | Br. J. Dermatol. | pmid:17711521 |
| Amin HM et al. | Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). | 2001 | Br. J. Haematol. | pmid:11703323 |
| Vinatzer U et al. | The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase. | 2001 | Br. J. Haematol. | pmid:11552981 |
| Welch MD et al. | Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia. | 2013 | Br. J. Haematol. | pmid:23772794 |
| Kitamura K et al. | Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. | 2000 | Br. J. Haematol. | pmid:10792271 |
| Yamamura K et al. | Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis. | 2006 | Br. J. Haematol. | pmid:16939493 |
| Li X et al. | Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. | 2010 | Br. J. Haematol. | pmid:19807731 |
| Kiefer J et al. | Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. | 2006 | Br. J. Nutr. | pmid:17092367 |
| Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |