| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Lupus Vulgaris | D008177 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xin C et al. | FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism. | 2007 | Br. J. Pharmacol. | pmid:17325654 |
| Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |
| Ishihara K et al. | Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils. | 2004 | Br. J. Pharmacol. | pmid:15210580 |
| Chen CZ et al. | The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well. | 2009 | Br. J. Pharmacol. | pmid:19785660 |
| Gaub P et al. | The histone acetyltransferase p300 promotes intrinsic axonal regeneration. | 2011 | Brain | pmid:21705428 |
| Li KK et al. | MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). | 2013 | Brain Pathol. | pmid:23227829 |
| Li KK et al. | MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. | 2013 | Brain Pathol. | pmid:23252729 |
| Lin YC et al. | Effects of trichostatin A on neuronal mu-opioid receptor gene expression. | 2008 | Brain Res. | pmid:18950606 |
| Suzuki-Mizushima Y et al. | Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. | 2002 | Brain Res. | pmid:12270499 |
| Sano M and Kitajima S | Inhibition of the nerve growth factor-induced outgrowth of neurites by trichostatin A requires protein synthesis de novo in PC12D cells. | 1996 | Brain Res. | pmid:9117395 |
| Wei L et al. | Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. | 2016 | Brain Res. | pmid:27312092 |
| Hou X et al. | HDAC inhibitor TSA ameliorates mechanical hypersensitivity and potentiates analgesic effect of morphine in a rat model of bone cancer pain by restoring μ-opioid receptor in spinal cord. | 2017 | Brain Res. | pmid:28559159 |
| Sharifulina SA et al. | Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact. | 2014 | Brain Res. Bull. | pmid:24502940 |
| Niu F et al. | Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-kappaB. | 2009 | Brain Res. Bull. | pmid:19103266 |
| Sakharkar AJ et al. | A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. | 2016 | Brain Struct Funct | pmid:26941165 |
| Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. | 2002 | Brain Tumor Pathol | pmid:12622137 |
| Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. | 2001 | Brain Tumor Pathol | pmid:11908866 |
| Zych J et al. | The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells. | 2013 | Braz. J. Med. Biol. Res. | pmid:23797495 |
| Kim SH et al. | Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein. | 2010 | Breast Cancer Res. | pmid:20388208 |
| Xu J et al. | CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors. | 2010 | Breast Cancer Res. Treat. | pmid:19466541 |
| Motevalli A et al. | The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines. | 2014 | Breast Cancer Res. Treat. | pmid:24807106 |
| Domingo-Domènech J et al. | Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. | 2008 | Breast Cancer Res. Treat. | pmid:18064564 |
| Huang KT et al. | Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer. | 2011 | Breast Cancer Res. Treat. | pmid:21755341 |
| Pryzbylkowski P et al. | Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. | 2008 | Breast Cancer Res. Treat. | pmid:17891453 |
| Auer D et al. | Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer. | 2009 | Breast Cancer Res. Treat. | pmid:18618240 |
| Guo W et al. | Aberrant methylation and decreased expression of the TGF-β/Smad target gene FBXO32 in esophageal squamous cell carcinoma. | 2014 | Cancer | pmid:24798237 |
| Pan L et al. | Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. | 2007 | Cancer | pmid:17330857 |
| Tan L et al. | Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells. | 2011 | Cancer | pmid:20925046 |
| Chen MY et al. | Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. | 2011 | Cancer | pmid:21491416 |
| Kim MK and Carroll WL | Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2. | 2004 | Cancer | pmid:15382088 |
| El-Awady RA et al. | Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. | 2015 | Cancer Biol. Ther. | pmid:25962089 |
| Lo PK et al. | Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. | 2006 | Cancer Biol. Ther. | pmid:16410723 |
| Taghiyev AF et al. | TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome. | 2006 | Cancer Biol. Ther. | pmid:17110788 |
| David GL et al. | MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine. | 2004 | Cancer Biol. Ther. | pmid:15034303 |
| Sangster-Guity N et al. | Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment. | 2004 | Cancer Biol. Ther. | pmid:15467438 |
| Song K et al. | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. | 2011 | Cancer Biol. Ther. | pmid:21709440 |
| Karagiannis TC et al. | The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X. | 2005 | Cancer Biol. Ther. | pmid:16082178 |
| Mazzarelli P et al. | Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? | 2007 | Cancer Biol. Ther. | pmid:18253084 |
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| Taghiyev AF et al. | Trichostatin A (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment. | 2005 | Cancer Biol. Ther. | pmid:15846101 |
| Chatterjee N et al. | Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. | 2013 | Cancer Biol. Ther. | pmid:23792638 |
| Anantharaju PG et al. | Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). | 2017 | Cancer Biol. Ther. | pmid:28506198 |
| Chakravarty G et al. | Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. | 2011 | Cancer Biol. Ther. | pmid:21084857 |
| Honda H et al. | Regulation of the CLDN3 gene in ovarian cancer cells. | 2007 | Cancer Biol. Ther. | pmid:17986852 |
| Zhang XH et al. | Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer. | 2008 | Cancer Biol. Ther. | pmid:18708766 |
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| Dowling M et al. | Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. | 2005 | Cancer Biol. Ther. | pmid:15753652 |
| Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
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