| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Vulgaris | D008177 | 1 associated lipids |
| Rubinstein-Taybi Syndrome | D012415 | 1 associated lipids |
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang XH et al. | S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. | 2010 | Am. J. Pathol. | pmid:20581057 |
| Thangavel J et al. | Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. | 2014 | Am. J. Pathol. | pmid:24929240 |
| Miyatake Y et al. | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. | 2013 | Am. J. Pathol. | pmid:23474084 |
| Nakamura J et al. | Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. | 2011 | Am. J. Pathol. | pmid:21281785 |
| Sato TA and Mitchell MD | Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234266 |
| Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
| Yang H et al. | Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11208539 |
| Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
| Wu JT et al. | Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11171632 |
| Pender SL et al. | Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11052988 |
| Sonoyama K et al. | Upregulation of activin A gene by butyrate in human colon cancer cell lines. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12540370 |
| Gang H et al. | Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23585133 |
| Davis FJ et al. | Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15388503 |
| Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
| Usui T et al. | HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22389387 |
| Zhang LX et al. | Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20382965 |
| Yang Q et al. | Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23043075 |
| Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
| Kuang PP et al. | Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17209135 |
| Mizuno S et al. | Inhibition of histone deacetylase causes emphysema. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21224215 |