| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Toscano MG et al. | SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. | 2015 | Mol. Ther. | pmid:25292191 |
| Devaney JM et al. | Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. | 2015 | Epigenetics | pmid:25864488 |
| Ganatra DA et al. | Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells. | 2015 | Eye (Lond) | pmid:25853442 |
| Iancu-Rubin C and Hoffman R | Role of epigenetic reprogramming in hematopoietic stem cell function. | 2015 | Curr. Opin. Hematol. | pmid:26049747 |
| Tao W et al. | Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. | 2015 | Mol. Pharmacol. | pmid:25852071 |
| Bieluszewski T et al. | AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. | 2015 | BMC Plant Biol. | pmid:25849764 |
| Rumbaugh G et al. | Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. | 2015 | Neuropsychopharmacology | pmid:25837283 |
| Acun T et al. | PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. | 2015 | OMICS | pmid:25831062 |
| Huisman C et al. | Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. | 2015 | Epigenetics | pmid:25830725 |
| Fujii K et al. | Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. | 2015 | J. Cell. Physiol. | pmid:25820447 |
| Pandey SC et al. | Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. | 2015 | Neurobiol. Dis. | pmid:25814047 |
| Chan N et al. | Attenuation of choroidal neovascularization by histone deacetylase inhibitor. | 2015 | PLoS ONE | pmid:25807249 |
| Dagnas M et al. | Post-training, intrahippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice. | 2015 | Hippocampus | pmid:25530477 |
| Qiao Y et al. | Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. | 2015 | J. Biol. Chem. | pmid:25519907 |
| Mataki H et al. | Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. | 2015 | J. Hum. Genet. | pmid:25518741 |
| Jeong SG and Cho GW | Trichostatin A modulates intracellular reactive oxygen species through SOD2 and FOXO1 in human bone marrow-mesenchymal stem cells. | 2015 | Cell Biochem. Funct. | pmid:25515622 |
| Hartman H et al. | Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice. | 2015 | Dig. Dis. Sci. | pmid:25492506 |
| Jiang H et al. | Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process. | 2015 | Acta Histochem. | pmid:25480399 |
| Rempel E et al. | A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. | 2015 | Arch. Toxicol. | pmid:26272509 |
| Dreser N et al. | Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. | 2015 | Neurotoxicology | pmid:26238599 |
| Wu Y et al. | Acetylation-dependent function of human single-stranded DNA binding protein 1. | 2015 | Nucleic Acids Res. | pmid:26170237 |
| Singh RD et al. | Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. | 2015 | Toxicol. Lett. | pmid:26008221 |
| Fukui T et al. | Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. | 2015 | Toxicology | pmid:25758465 |
| Pinz S et al. | Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. | 2015 | Nucleic Acids Res. | pmid:25769527 |
| Wang Y et al. | Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. | 2015 | Chem. Biol. | pmid:25699604 |
| Chahine MN et al. | Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. | 2015 | Cardiovasc. Res. | pmid:25341891 |
| Sobolewski C et al. | Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. | 2015 | Biomolecules | pmid:26343742 |
| Ji M et al. | HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. | 2015 | Oncol. Rep. | pmid:25813246 |
| Brandão FA et al. | Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. | 2015 | Virulence | pmid:26103530 |
| Sugimoto H et al. | Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits. | 2015 | Zygote | pmid:24666637 |
| Li Z et al. | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. | 2015 | Gastric Cancer | pmid:24481854 |
| Alvarez AA et al. | The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells. | 2015 | J. Mol. Neurosci. | pmid:24874578 |
| Rodrigues MF et al. | Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. | 2015 | J. Cell. Biochem. | pmid:25510910 |
| Ma L et al. | HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1. | 2015 | Mol. Endocrinol. | pmid:26357899 |
| Uchida H et al. | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. | 2015 | J. Pharmacol. Sci. | pmid:26318673 |
| Zhang Y et al. | Effect of histone deacetylase on prostate carcinoma. | 2015 | Int J Clin Exp Pathol | pmid:26823840 |
| Feng W et al. | Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells. | 2015 | Biomed. Pharmacother. | pmid:26349994 |
| Li YL et al. | Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer. | 2015 | Int J Clin Exp Pathol | pmid:26339382 |
| Zhang P et al. | Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. | 2015 | PLoS ONE | pmid:26287365 |
| Perez-Janices N et al. | Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis. | 2015 | Oncotarget | pmid:26284587 |
| Keil KP et al. | Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. | 2015 | Dev. Dyn. | pmid:26283270 |
| Lee YR et al. | Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. | 2015 | Oncotarget | pmid:26125438 |
| Thangavel J et al. | Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. | 2015 | J. Cell. Sci. | pmid:26116574 |
| Kanasaki H et al. | Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. | 2015 | Mol. Cell. Endocrinol. | pmid:26116234 |
| Dupré-Aucouturier S et al. | Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. | 2015 | J. Appl. Physiol. | pmid:26112243 |
| Liu J et al. | Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086099 |
| Huang J et al. | Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway. | 2015 | Int. J. Mol. Med. | pmid:26080623 |
| Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
| Huan Y et al. | Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. | 2015 | Cell Reprogram | pmid:26053519 |
| Kaldre D et al. | Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. | 2015 | Bioorg. Med. Chem. | pmid:26048026 |