| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Biliary Tract Neoplasms | D001661 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen WP et al. | Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. | 2011 | Rheumatol. Int. | pmid:20390279 |
| Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
| Ohnishi K | [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | 2006 | Rinsho Ketsueki | pmid:16986710 |
| Katsuno M et al. | [Dysfunction of dynactin 1 in motor neuron degeneration]. | 2013 | Rinsho Shinkeigaku | pmid:24291886 |
| Vadie N et al. | MYCNOS functions as an antisense RNA regulating MYCN. | 2015 | RNA Biol | pmid:26156430 |
| Gavin DP et al. | Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. | 2008 | Schizophr. Res. | pmid:18539439 |
| Inoue K et al. | Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. | 2015 | Sci Rep | pmid:25974394 |
| Rong X et al. | Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. | 2016 | Sci Rep | pmid:27703255 |
| Liu J et al. | Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. | 2013 | Sci Rep | pmid:23378917 |
| Cai MH et al. | Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine. | 2018 | Sci Rep | pmid:29374219 |
| Ikeda K et al. | In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model. | 2017 | Sci Rep | pmid:28300163 |
| Gupta DK et al. | DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. | 2016 | Sci Rep | pmid:27033103 |
| Deguise MO et al. | Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. | 2016 | Sci Rep | pmid:27349908 |
| Svegliati S et al. | Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. | 2014 | Sci Signal | pmid:25185156 |
| Cheutin T et al. | Maintenance of stable heterochromatin domains by dynamic HP1 binding. | 2003 | Science | pmid:12560555 |
| Chen Lf W et al. | Duration of nuclear NF-kappaB action regulated by reversible acetylation. | 2001 | Science | pmid:11533489 |
| Nambu Y et al. | Transcription-coupled events associating with immunoglobulin switch region chromatin. | 2003 | Science | pmid:14684824 |
| Wang H et al. | Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. | 2001 | Science | pmid:11387442 |
| Bakin AV and Curran T | Role of DNA 5-methylcytosine transferase in cell transformation by fos. | 1999 | Science | pmid:9888853 |
| Jung J and Bonini N | CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. | 2007 | Science | pmid:17332375 |