trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Abnormalities, Multiple D000015 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Asthma D001249 52 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Zhang Y and Zhang B Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. 2016 J. Biochem. Mol. Toxicol. pmid:26509796
Ranganathan P et al. Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. 2016 Kidney Int. pmid:26509586
Selokar NL et al. Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. 2016 Zygote pmid:26503476
Nakada Y et al. Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells. 2015 Endocr. J. pmid:26497760
Martini M et al. Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation. 2015 Mediators Inflamm. pmid:26491230
Uchida H and Ito S Differential regulation of expression of RNA-editing enzymes, ADAR1 and ADAR2, by 5-aza-2'-deoxycytidine and trichostatin A in human neuronal SH-SY5Y cells. 2015 Neuroreport pmid:26485095
Barr MP et al. VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach. 2015 Epigenomics pmid:26479311
Li PT et al. Increased Histone Deacetylase Activity Involved in the Suppressed Invasion of Cancer Cells Survived from ALA-Mediated Photodynamic Treatment. 2015 Int J Mol Sci pmid:26473836
Liu J and Li Y Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. 2015 Biochem. Biophys. Res. Commun. pmid:26436206
Cai D et al. Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. 2015 Arthritis Res. Ther. pmid:26408027
Rolando M et al. Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery. 2015 Cytoskeleton (Hoboken) pmid:26403219
Alizadeh E et al. Upregulation of MiR-122 via Trichostatin A Treatments in Hepatocyte-like Cells Derived from Mesenchymal Stem Cells. 2016 Chem Biol Drug Des pmid:26360933
Ma L et al. HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1. 2015 Mol. Endocrinol. pmid:26357899
Feng W et al. Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells. 2015 Biomed. Pharmacother. pmid:26349994
Sobolewski C et al. Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. 2015 Biomolecules pmid:26343742
Kim HJ et al. Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. 2016 Biotechnol. Lett. pmid:26341652
Li YL et al. Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer. 2015 Int J Clin Exp Pathol pmid:26339382
Contreras-Leal E et al. Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. 2016 Mol. Carcinog. pmid:26331238
Uchida H et al. Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. 2015 J. Pharmacol. Sci. pmid:26318673
Zhang P et al. Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. 2015 PLoS ONE pmid:26287365
Perez-Janices N et al. Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis. 2015 Oncotarget pmid:26284587
Keil KP et al. Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. 2015 Dev. Dyn. pmid:26283270
Meng Z et al. PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. 2016 Oncogene pmid:26279303
Hsing CH et al. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. 2015 Mediators Inflamm. pmid:26273133
Rempel E et al. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. 2015 Arch. Toxicol. pmid:26272509
Zhou L et al. Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis. 2015 J. Virol. pmid:26269170
Pang X et al. Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. 2016 Tumour Biol. pmid:26264615
Passeri E et al. Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. 2015 Neurosci. Res. pmid:26260244
Zheng J et al. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). 2015 Eur. J. Immunol. pmid:26255980
Dreser N et al. Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. 2015 Neurotoxicology pmid:26238599
Kim SH et al. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. 2016 Endocrine pmid:26219406
Mehta A et al. HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. 2015 Mol. Cell. Endocrinol. pmid:26213324
Sancak D and Ozden S Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. 2015 Toxicol In Vitro pmid:26208285
Cabanel M et al. Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. 2015 PLoS ONE pmid:26196676
Suo H et al. NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. 2015 Neuropharmacology pmid:26188143
Gutiérrez J et al. Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. 2015 Mol. Cell. Biochem. pmid:26173416
Wu Y et al. Acetylation-dependent function of human single-stranded DNA binding protein 1. 2015 Nucleic Acids Res. pmid:26170237
Hedberg Oldfors C et al. Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. 2015 BMC Genet. pmid:26170120
Ji S et al. [Association of irradiation-induced hippocampal neurogenesis impairment with histone H3 acetylation]. 2015 Zhonghua Yi Xue Za Zhi pmid:26168675
Tan CS et al. Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. 2016 Mol. Neurobiol. pmid:26162318
Liao HF et al. Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. 2015 Reproduction pmid:26159833
Vadie N et al. MYCNOS functions as an antisense RNA regulating MYCN. 2015 RNA Biol pmid:26156430
Ota C et al. Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. 2015 Exp. Lung Res. pmid:26151196
Singh AK et al. Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. 2015 Clin. Cancer Res. pmid:26130461
Lee YR et al. Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. 2015 Oncotarget pmid:26125438
Thangavel J et al. Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. 2015 J. Cell. Sci. pmid:26116574
Kanasaki H et al. Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. 2015 Mol. Cell. Endocrinol. pmid:26116234
Dupré-Aucouturier S et al. Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. 2015 J. Appl. Physiol. pmid:26112243
Brandão FA et al. Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. 2015 Virulence pmid:26103530
Liu J et al. Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. 2015 Biochem. Biophys. Res. Commun. pmid:26086099
Huang J et al. Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway. 2015 Int. J. Mol. Med. pmid:26080623
Huan Y et al. Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. 2015 PLoS ONE pmid:26068219
Huan Y et al. Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. 2015 Cell Reprogram pmid:26053519
Iancu-Rubin C and Hoffman R Role of epigenetic reprogramming in hematopoietic stem cell function. 2015 Curr. Opin. Hematol. pmid:26049747
Kaldre D et al. Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. 2015 Bioorg. Med. Chem. pmid:26048026
Liu Y and Li S A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. 2015 ORL J. Otorhinolaryngol. Relat. Spec. pmid:26022499
Jost JO et al. A miniaturized readout strategy for endogenous histone deacetylase activity. 2015 Mol Biosyst pmid:26009008
Singh RD et al. Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. 2015 Toxicol. Lett. pmid:26008221
Koppaka V et al. Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. 2015 Mol. Vis. pmid:25999677
Ukaegbu UE et al. A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. 2015 PLoS Genet. pmid:25993442
Chen Z et al. Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment. 2015 Anticancer Agents Med Chem pmid:25991546
Nayak S et al. Superior Versus Inferior Vestibular Neuritis: Are There Intrinsic Differences in Infection, Reactivation, or Production of Infectious Particles Between the Vestibular Ganglia? 2015 Otol. Neurotol. pmid:25978655
Chen MH et al. A new trichostatin analog from Streptomyces sp. CPCC 203909. 2015 J Asian Nat Prod Res pmid:25977996
Inoue K et al. Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. 2015 Sci Rep pmid:25974394
El-Awady RA et al. Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. 2015 Cancer Biol. Ther. pmid:25962089
Huan Y et al. Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. 2015 PLoS ONE pmid:25962071
Koumbadinga GA et al. Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. 2015 Biochim. Biophys. Acta pmid:25959059
Meschini R et al. Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. 2015 Mutat. Res. pmid:25942615
Ooi JY et al. HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. 2015 Epigenetics pmid:25941940
Marquardt JU et al. Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. 2015 J. Hepatol. pmid:25937435
Han Y et al. Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors. 2015 Exp. Cell Res. pmid:25933513
Mishra DR et al. Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. 2015 PLoS ONE pmid:25923237
Zhao W et al. A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation. 2015 J Chin Med Assoc pmid:25913212
Lin S et al. IL-4 Modulates Macrophage Polarization in Ankylosing Spondylitis. 2015 Cell. Physiol. Biochem. pmid:25896783
Di Zanni E et al. Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells. 2015 Exp. Cell Res. pmid:25882494
Nordström L et al. DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. 2015 BMC Cancer pmid:25880212
Samiec M et al. Trichostatin A-mediated epigenetic transformation of adult bone marrow-derived mesenchymal stem cells biases the in vitro developmental capability, quality, and pluripotency extent of porcine cloned embryos. 2015 Biomed Res Int pmid:25866813
Hou H et al. Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model. 2015 Biomed Res Int pmid:25866784
Devaney JM et al. Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. 2015 Epigenetics pmid:25864488
Ganatra DA et al. Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells. 2015 Eye (Lond) pmid:25853442
Tao W et al. Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. 2015 Mol. Pharmacol. pmid:25852071
Bieluszewski T et al. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. 2015 BMC Plant Biol. pmid:25849764
Rumbaugh G et al. Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. 2015 Neuropsychopharmacology pmid:25837283
Acun T et al. PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. 2015 OMICS pmid:25831062
Huisman C et al. Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. 2015 Epigenetics pmid:25830725
Fujii K et al. Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. 2015 J. Cell. Physiol. pmid:25820447
Pandey SC et al. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. 2015 Neurobiol. Dis. pmid:25814047
Ji M et al. HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. 2015 Oncol. Rep. pmid:25813246
Chan N et al. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. 2015 PLoS ONE pmid:25807249
Asaoka N et al. Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. 2015 Neurosci. Lett. pmid:25796177
Tao Y et al. HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. 2015 PLoS ONE pmid:25789466
Butler PL et al. Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. 2015 J. Biol. Chem. pmid:25787079
Yamanegi K et al. Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. 2015 Int. J. Oncol. pmid:25778932
Pinz S et al. Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. 2015 Nucleic Acids Res. pmid:25769527
Cao QF et al. TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. 2015 Cancer Biother. Radiopharm. pmid:25760728
Fukui T et al. Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. 2015 Toxicology pmid:25758465
Mackmull MT et al. Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). 2015 Mol. Cell Proteomics pmid:25755299
Zelko IN and Folz RJ Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. 2015 Am. J. Respir. Cell Mol. Biol. pmid:25749103
Cao K et al. Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. 2015 Oncogene pmid:25745993
Mostafavi-Pour Z et al. Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer. 2015 Pathol. Oncol. Res. pmid:25743258