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Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. |
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2001 |
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Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. |
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Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in Xenopus. |
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Biol. Chem. |
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Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. |
2000 |
Cancer Res. |
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Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |
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Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. |
2000 |
Biol. Chem. |
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Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. |
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Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. |
2000 |
Cell |
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p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. |
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The mouse tumor cell lines EL4 and RMA display mosaic expression of NK-related and certain other surface molecules and appear to have a common origin. |
2000 |
J. Immunol. |
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Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine. |
2000 |
Gene Ther. |
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Stimulation of V(D)J recombination by histone acetylation. |
2000 |
Curr. Biol. |
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Hobbs CA and Gilmour SK |
High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. |
2000 |
J. Cell. Biochem. |
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2000 |
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2000 |
Nucleic Acids Res. |
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Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. |
2000 |
Clin. Exp. Metastasis |
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Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. |
2000 |
Br. J. Haematol. |
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Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. |
2000 |
Mol. Cell. Biol. |
pmid:11046157
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The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. |
2000 |
J. Biol. Chem. |
pmid:10921928
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Chang LK and Liu ST |
Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylation. |
2000 |
Nucleic Acids Res. |
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Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. |
2000 |
Int. J. Cancer |
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Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. |
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J. Biol. Chem. |
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Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. |
2000 |
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Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction. |
2000 |
Dev. Dyn. |
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IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. |
2000 |
Cytokine |
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A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. |
2000 |
Cancer Res. |
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Unique anti-activator protein-1 activity of retinoic acid receptor beta. |
2000 |
Cancer Res. |
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Human Slug is a repressor that localizes to sites of active transcription. |
2000 |
Mol. Cell. Biol. |
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Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10841572
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Claassen GF and Hann SR |
A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10920185
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Mao C and Shapiro DJ |
A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. |
2000 |
Endocrinology |
pmid:10875235
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Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. |
2000 |
EMBO J. |
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Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. |
2000 |
J. Biol. Chem. |
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Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. |
2000 |
Mol. Cell. Biol. |
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Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation. |
2000 |
Gene |
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Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. |
2000 |
Eur. J. Biochem. |
pmid:10691972
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. |
2000 |
Nature |
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Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. |
2000 |
Oncogene |
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BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. |
2000 |
Mol. Cell. Biol. |
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Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene. |
2000 |
Endocrinology |
pmid:11108251
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Eickhoff B et al. |
Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. |
2000 |
Biol. Chem. |
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Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. |
2000 |
Cancer Res. |
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Epigenetic regulation of androgen receptor gene expression in human prostate cancers. |
2000 |
Lab. Invest. |
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Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. |
2000 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:11052988
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Tobias CA et al. |
Improved recombinant retroviral titers utilizing trichostatin A. |
2000 |
BioTechniques |
pmid:11056820
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