trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Adachi T et al. Histone deacetylase inhibitors stimulate the susceptibility of A549 cells to a plasma-activated medium treatment. 2016 Arch. Biochem. Biophys. pmid:27470189
Katula KS et al. Cell cycle specific changes in the human cyclin B1 gene regulatory region as revealed by response to trichostatin A. 2002 Arch. Biochem. Biophys. pmid:12054478
Garrison PM et al. Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. 2000 Arch. Biochem. Biophys. pmid:10666294
Diao JS et al. Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. 2011 Arch. Dermatol. Res. pmid:21400246
Zhu K et al. Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. 2008 Arch. Gynecol. Obstet. pmid:17680259
Hizume K et al. Nano-scale analyses of the chromatin decompaction induced by histone acetylation. 2010 Arch. Histol. Cytol. pmid:22572182
Royce SG et al. Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice. 2012 Arch. Immunol. Ther. Exp. (Warsz.) pmid:22684086
Piotrowska H and Jagodzinski PP Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. 2009 Arch. Med. Res. pmid:19427965
Hou SY et al. Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. 2014 Arch. Med. Res. pmid:24316396
Yu L et al. Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis. 2012 Arch. Med. Res. pmid:22564421
Cunneen TS et al. In vitro effects of histone deacetylase inhibitors and mitomycin C on tenon capsule fibroblasts and conjunctival melanoma cells. 2009 Arch. Ophthalmol. pmid:19365017
Schmidt K et al. Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. 1999 Arch. Pharm. (Weinheim) pmid:10575368
Ahn MR et al. Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. 2004 Arch. Pharm. Res. pmid:15180307
Han SB and Lee JK Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages. 2009 Arch. Pharm. Res. pmid:19407980
Kim SN et al. Regulation of adipocyte differentiation by histone deacetylase inhibitors. 2009 Arch. Pharm. Res. pmid:19407971
Joung KE et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. 2004 Arch. Pharm. Res. pmid:15283467
Min KN et al. Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. 2004 Arch. Pharm. Res. pmid:15202563
Rempel E et al. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. 2015 Arch. Toxicol. pmid:26272509
Balmer NV et al. From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. 2014 Arch. Toxicol. pmid:24935251
Cipriano M et al. The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells. 2017 Arch. Toxicol. pmid:27909741