Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lim Y et al. | Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. | 2002 | J. Biol. Chem. | pmid:11821402 |
Ego T et al. | The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. | 2002 | Oncogene | pmid:12370815 |
Kikuchi T et al. | Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. | 2002 | Int. J. Cancer | pmid:11774276 |
Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
Sourlingas TG et al. | The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. | 2002 Jan-Mar | Exp. Gerontol. | pmid:11772521 |
Iwata K et al. | Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470611 |
Noss KR et al. | Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. | 2002 May-Jun | Anticancer Res. | pmid:12168830 |
Rahman I et al. | Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. | 2002 May-Jun | Mol. Cell. Biochem. | pmid:12162440 |
Glaser KB et al. | Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. | 2003 | Mol. Cancer Ther. | pmid:12589032 |
Ailenberg M and Silverman M | Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604329 |
Sakai N et al. | Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. | 2003 | J. Biol. Chem. | pmid:12609987 |
Kim SY et al. | Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. | 2003 | J. Virol. | pmid:12610114 |
Wang S and Zhu J | Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. | 2003 | J. Biol. Chem. | pmid:12611896 |
Shaker S et al. | Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. | 2003 | Leuk. Res. | pmid:12620295 |
McGhee L et al. | Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. | 2003 | J. Cell. Biochem. | pmid:12874834 |
Chun AC and Jin DY | Transcriptional regulation of mitotic checkpoint gene MAD1 by p53. | 2003 | J. Biol. Chem. | pmid:12876282 |
Grisolano JL et al. | An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12881486 |
Moreira JM et al. | The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. | 2003 | BMC Cancer | pmid:14606959 |
Noh EJ and Lee JS | Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2-M transition. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14521905 |
Li C et al. | Effect and comparison of sodium butyrate and trichostatin A on the proliferation/differentiation of K562. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:14526425 |
Hejnar J et al. | Demethylation of host-cell DNA at the site of avian retrovirus integration. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14623319 |
Margueron R et al. | Oestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells. | 2003 | J. Endocrinol. | pmid:14529564 |
Witt O et al. | Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. | 2003 | Blood | pmid:12393499 |
Yang L et al. | An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. | 2003 | Biochem. J. | pmid:12398767 |
Klisovic DD et al. | Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12766035 |
Zhang Q et al. | Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14575637 |
Usenko T et al. | Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. | 2003 | Oncogene | pmid:14576829 |
Vasudevan A et al. | Heterocyclic ketones as inhibitors of histone deacetylase. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592473 |
Chung YL et al. | A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. | 2003 | Mol. Ther. | pmid:14599803 |
Lu F et al. | Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. | 2003 | J. Virol. | pmid:14557628 |
Siddiqui H et al. | Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. | 2003 | Mol. Cell. Biol. | pmid:14560017 |
Martin D et al. | Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines. | 2003 | J. Biol. Chem. | pmid:14565956 |
Kim H et al. | The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816733 |
Klan N et al. | Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. | 2003 | Biol. Chem. | pmid:12817474 |
Yamada Y et al. | Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. | 2003 | Cancer Sci. | pmid:12824880 |
Shi W et al. | Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. | 2003 | Biol. Reprod. | pmid:12646489 |
Murumägi A et al. | Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. | 2003 | J. Biol. Chem. | pmid:12651856 |
Kang J et al. | Nickel-induced histone hypoacetylation: the role of reactive oxygen species. | 2003 | Toxicol. Sci. | pmid:12773760 |
Maatouk DM and Resnick JL | Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation. | 2003 | Dev. Biol. | pmid:12781693 |
Ju R and Muller MT | Histone deacetylase inhibitors activate p21(WAF1) expression via ATM. | 2003 | Cancer Res. | pmid:12782595 |
Zika E et al. | Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. | 2003 | Mol. Cell. Biol. | pmid:12697811 |
Mihaylova VT et al. | Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. | 2003 | Mol. Cell. Biol. | pmid:12697826 |
Kao GD et al. | Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. | 2003 | J. Cell Biol. | pmid:12668657 |
Yasui W et al. | Histone acetylation and gastrointestinal carcinogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12724227 |
Jedrusik MA and Schulze E | Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. | 2003 | Mol. Cell. Biol. | pmid:12724425 |
Vos MD et al. | The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. | 2003 | J. Biol. Chem. | pmid:12676952 |
Detich N et al. | The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. | 2003 | J. Biol. Chem. | pmid:12676953 |
Foubister V | Anticancer drug shows promise against lupus. | 2003 | Drug Discov. Today | pmid:12681930 |
Park WH et al. | Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. | 2003 | Int. J. Oncol. | pmid:12684681 |