Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Park H et al. | Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. | 2008 | Int. J. Mol. Med. | pmid:18949380 |
Dowling DP et al. | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. | 2008 | Biochemistry | pmid:19053282 |
Ishii T et al. | [Epigenetic regulation in alcohol-related brain damage]. | 2008 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:19068777 |
Gray SG et al. | Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. | 2008 | Clin Lung Cancer | pmid:19073520 |
Zhu K et al. | Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. | 2008 | Arch. Gynecol. Obstet. | pmid:17680259 |
Chou CW and Chen CC | HDAC inhibition upregulates the expression of angiostatic ADAMTS1. | 2008 | FEBS Lett. | pmid:19007777 |
Nair S et al. | Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. | 2008 | Pharm. Res. | pmid:17657594 |
Setiadi AF et al. | Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. | 2008 | Cancer Res. | pmid:19047136 |
Mizumoto S et al. | The developmental potential of parthenogenetic and somatic cell nuclear-transferred rat oocytes in vitro. | 2008 | Cloning Stem Cells | pmid:19049415 |
Zhou Q et al. | Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. | 2008 | Mol. Vis. | pmid:19122829 |
Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP]. | 2008 | Ai Zheng | pmid:19079988 |
Usami M et al. | Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. | 2008 | Nutr Res | pmid:19083427 |
Krämer OH et al. | Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. | 2008 | Oncogene | pmid:17653085 |
Tanaka M et al. | The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination. | 2008 | Plant Physiol. | pmid:18024558 |
Ramirez T et al. | Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. | 2008 | Chromosoma | pmid:17999076 |
Arany I et al. | Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18094030 |
Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
Nasu Y et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. | 2008 | Osteoarthr. Cartil. | pmid:18226559 |
Lim HG et al. | Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. | 2008 | Mol. Ther. | pmid:18227841 |
Ruau D et al. | Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. | 2008 | Stem Cells | pmid:18203677 |
Serrano E et al. | Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. | 2008 | Leuk. Res. | pmid:18206229 |
Hamner JB et al. | The efficacy of combination therapy using adeno-associated virus--interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. | 2008 | J. Pediatr. Surg. | pmid:18206478 |
Duhamel M et al. | Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. | 2008 | FEBS Lett. | pmid:18206652 |
Joseph RA et al. | Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking. | 2008 | Hepatology | pmid:18161881 |
Shi LH et al. | Trichostatin A and nuclear reprogramming of cloned rabbit embryos. | 2008 | J. Anim. Sci. | pmid:18245503 |
Paris M et al. | Histone deacetylase inhibitors: from bench to clinic. | 2008 | J. Med. Chem. | pmid:18247554 |
Gupta MP et al. | HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. | 2008 | J. Biol. Chem. | pmid:18250163 |
Politis PK et al. | BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells. | 2008 | FEBS Lett. | pmid:18258204 |
Byers J and Eichinger D | Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. | 2008 | Int. J. Parasitol. | pmid:17706222 |
Campanero MR et al. | The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. | 2008 | Oncogene | pmid:17724474 |
Manning J et al. | Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. | 2008 | Immunology | pmid:17725605 |
Balakrishnan L and Milavetz B | HDAC inhibitors stimulate viral transcription by multiple mechanisms. | 2008 | Virol. J. | pmid:18353181 |
Pan J et al. | TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells. | 2008 | Mol. Cancer Res. | pmid:18505930 |
Hou J et al. | Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation. | 2008 | BMC Dev. Biol. | pmid:18507869 |
Dalgard CL et al. | Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. | 2008 | Clin. Cancer Res. | pmid:18483379 |
Egler V et al. | Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death. | 2008 | Clin. Cancer Res. | pmid:18483381 |
Chen Y et al. | A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. | 2008 | J. Med. Chem. | pmid:18494463 |
Oliva J et al. | Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. | 2008 | Exp. Mol. Pathol. | pmid:18280469 |
Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
Yu WP et al. | Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells. | 2008 | Cell Prolif. | pmid:18211287 |
Kikuno N et al. | Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. | 2008 | Int. J. Cancer | pmid:18431742 |
van West P et al. | Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling. | 2008 | Microbiology (Reading, Engl.) | pmid:18451057 |
Zhang HJ et al. | Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. | 2008 | Placenta | pmid:18440631 |
Liu Z et al. | Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells. | 2008 | Oncol. Rep. | pmid:18575731 |
Meja KK et al. | Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18421014 |
Plouffe D et al. | In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18579783 |
Sebastián C et al. | Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. | 2008 | J. Immunol. | pmid:18424709 |
Sun Y et al. | Modulation of transcription parameters in glucocorticoid receptor-mediated repression. | 2008 | Mol. Cell. Endocrinol. | pmid:18583028 |
Tshuikina M et al. | Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. | 2008 | Exp. Hematol. | pmid:18922617 |
Biacsi R et al. | SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. | 2008 | PLoS Genet. | pmid:18369442 |
Hishikawa K and Fujita T | [Kidney regeneration update]. | 2008 | Nippon Rinsho | pmid:18464514 |
Wu X et al. | Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development. | 2008 | Anim. Biotechnol. | pmid:18855246 |
Lindström TM et al. | Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells. | 2008 | Mol. Pharmacol. | pmid:18375836 |
Kato A et al. | Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. | 2008 | Exp. Cell Res. | pmid:18588874 |
Li J et al. | High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos. | 2008 | Theriogenology | pmid:18573521 |
Xu ZM et al. | The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage. | 2008 | BMB Rep | pmid:18377727 |
Chen CJ et al. | Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells. | 2008 | Eur. J. Pharmacol. | pmid:18590721 |
Karantzali E et al. | Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis. | 2008 | Genome Biol. | pmid:18394158 |
Marengo E et al. | Evaluation of the variables characterized by significant discriminating power in the application of SIMCA classification method to proteomic studies. | 2008 | J. Proteome Res. | pmid:18543959 |
Ree AH et al. | HDAC2 deficiency and histone acetylation. | 2008 | Nat. Genet. | pmid:18583969 |
Galiová G et al. | Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. | 2008 | Eur. J. Cell Biol. | pmid:18396346 |
Zhu X et al. | Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18544619 |
Liu Y et al. | Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines. | 2008 | Cancer Invest. | pmid:18584348 |
Gaviraghi M et al. | Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene. | 2008 | BMC Mol. Biol. | pmid:18549468 |
Nakao Y et al. | Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18397826 |
Mühlethaler-Mottet A et al. | Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. | 2008 | Mol. Cancer | pmid:18549473 |
Chen PC et al. | Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group. | 2008 | Bioorg. Med. Chem. | pmid:18397827 |
Kim B et al. | Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. | 2008 | Eur. J. Pharmacol. | pmid:18550052 |
Tavera-Mendoza LE et al. | Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18550844 |
Lee TB et al. | Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. | 2008 | BMC Gastroenterol | pmid:18673531 |
Xiang N et al. | Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. | 2008 | Carcinogenesis | pmid:18676679 |
Northrop JK et al. | Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells. | 2008 | J. Immunol. | pmid:18606637 |
Iager AE et al. | Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos. | 2008 | Cloning Stem Cells | pmid:18419249 |
Liu TC et al. | Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. | 2008 | Mol. Ther. | pmid:18388912 |
Reilly CM et al. | The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. | 2008 | J. Autoimmun. | pmid:18650065 |
Pluemsampant S et al. | Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. | 2008 | Int. J. Cancer | pmid:17935135 |
Law AY et al. | Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation. | 2008 | Exp. Cell Res. | pmid:18652825 |
Bosisio D et al. | Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. | 2008 | J. Leukoc. Biol. | pmid:18780875 |
Yang L et al. | [Effect of decitabine combined with Trichostatin A on MDS cell line SKM-1 in vitro]. | 2008 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18718068 |
Zou XM et al. | Gastric cancer cell lines induced by trichostatin A. | 2008 | World J. Gastroenterol. | pmid:18720545 |
Nishino N et al. | Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides. | 2008 | Bioorg. Med. Chem. | pmid:17900911 |
Duan H et al. | Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. | 2008 | Oncogene | pmid:18695675 |
Ding X et al. | Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A. | 2008 | Theriogenology | pmid:18556056 |
Jia J and Chen J | Histone hyperacetylation is involved in the quercetin-induced human leukemia cell death. | 2008 | Pharmazie | pmid:18557424 |
Su RC et al. | Epigenetic regulation of established human type 1 versus type 2 cytokine responses. | 2008 | J. Allergy Clin. Immunol. | pmid:17980413 |
Narver HL et al. | Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. | 2008 | Ann. Neurol. | pmid:18661558 |
Yu J et al. | Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. | 2008 | Hepatology | pmid:18666234 |
Iacobazzi V et al. | Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706393 |
Falk M et al. | Chromatin structure influences the sensitivity of DNA to gamma-radiation. | 2008 | Biochim. Biophys. Acta | pmid:18706456 |
Zhang XH et al. | Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer. | 2008 | Cancer Biol. Ther. | pmid:18708766 |
Liu F et al. | Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. | 2008 | J. Mol. Cell. Cardiol. | pmid:18926829 |
Gu Z et al. | Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas. | 2008 | Genes Genet. Syst. | pmid:18931460 |
Yoshioka H et al. | Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. | 2008 | J. Biol. Chem. | pmid:18801729 |
Wu Y and Guo SW | Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. | 2008 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17376583 |
Jin B et al. | DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. | 2008 | Hum. Mol. Genet. | pmid:18029387 |
Han JQ et al. | [Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18822204 |
Lee EJ et al. | Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. | 2008 | Int. J. Oncol. | pmid:18813790 |
Van Wagoner DR and Nattel S | Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. | 2008 | J. Mol. Cell. Cardiol. | pmid:18817781 |
Pellicciotta I et al. | Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. | 2008 | Cancer Res. | pmid:18829567 |
Hitchler MJ et al. | Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells. | 2008 | Free Radic. Biol. Med. | pmid:18845242 |