Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Bence M et al. | Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. | 2012 | J Neural Transm | pmid:21785940 |
Suh HS et al. | Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. | 2010 | J Neuroimmune Pharmacol | pmid:20157787 |
Fleiss B et al. | Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. | 2012 | J Neuroinflammation | pmid:22512781 |
Noro R et al. | The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application. | 2009 | J Nippon Med Sch | pmid:19305113 |
Por ED et al. | Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. | 2016 | J Ocul Pharmacol Ther | pmid:27494828 |
Sun G et al. | Insights into the lysine acetylproteome of human sperm. | 2014 | J Proteomics | pmid:25038526 |
Gavin DP et al. | Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. | 2009 | J Psychiatr Res | pmid:19187942 |
Gavin DP et al. | Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. | 2009 | J Psychiatry Neurosci | pmid:19448855 |
Albertus DL et al. | AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. | 2008 | J Thorac Oncol | pmid:18978557 |
Seo SK et al. | Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. | 2011 | J Thorac Oncol | pmid:21642861 |
Selinger CI et al. | Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. | 2011 | J Thorac Oncol | pmid:21597389 |
Kakihana M et al. | Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition. | 2009 | J Thorac Oncol | pmid:20009910 |
Kimura T et al. | Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. | 2011 | J Toxicol Sci | pmid:21467744 |
Simões-Pires CA et al. | Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. | 2017 | J Vis Exp | pmid:28829415 |
Azuma R et al. | Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer. | 2018 | J Vis Exp | pmid:29757287 |
Valapour M et al. | Histone deacetylation inhibits IL4 gene expression in T cells. | 2002 | J. Allergy Clin. Immunol. | pmid:11842291 |
Su RC et al. | Epigenetic regulation of established human type 1 versus type 2 cytokine responses. | 2008 | J. Allergy Clin. Immunol. | pmid:17980413 |
Milagre I et al. | Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. | 2010 | J. Alzheimers Dis. | pmid:20930312 |
Kudo K et al. | Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. | 2017 | J. Am. Chem. Soc. | pmid:28497964 |
Ren C et al. | Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:16099169 |
Yoshikawa M et al. | Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. | 2007 | J. Am. Soc. Nephrol. | pmid:17135397 |
Yu Z et al. | Histone deacetylases augment cytokine induction of the iNOS gene. | 2002 | J. Am. Soc. Nephrol. | pmid:12138131 |
Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
Fenic I et al. | In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. | 2008 Mar-Apr | J. Androl. | pmid:18046049 |
Fenic I et al. | In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. | 2004 Sep-Oct | J. Androl. | pmid:15292114 |
Shi LH et al. | Trichostatin A and nuclear reprogramming of cloned rabbit embryos. | 2008 | J. Anim. Sci. | pmid:18245503 |
Ueda JY et al. | JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. | 2009 | J. Antibiot. | pmid:19300468 |
Yoshida M et al. | Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells. | 1990 | J. Antibiot. | pmid:2211374 |
Otoguro K et al. | Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of trichostatin A. | 1988 | J. Antibiot. | pmid:3372352 |
Takahashi I et al. | Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase. | 1996 | J. Antibiot. | pmid:8682722 |
Komatsu Y and Hayashi H | Histone deacetylase inhibitors up-regulate the expression of cell surface MHC class-I molecules in B16/BL6 cells. | 1998 | J. Antibiot. | pmid:9531994 |
Koguchi Y et al. | Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor. | 1997 | J. Antibiot. | pmid:9592573 |
Kim YB et al. | Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. | 2000 | J. Antibiot. | pmid:11132966 |
Dupré-Aucouturier S et al. | Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. | 2015 | J. Appl. Physiol. | pmid:26112243 |
Jafari S et al. | Epigenetic modification does not determine the time of POU5F1 transcription activation in cloned bovine embryos. | 2011 | J. Assist. Reprod. Genet. | pmid:22020531 |
Slattery EL et al. | Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. | 2009 | J. Assoc. Res. Otolaryngol. | pmid:19340485 |
Azechi T et al. | Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. | 2013 | J. Atheroscler. Thromb. | pmid:23518467 |
Okamoto H et al. | Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). | 2006 | J. Atheroscler. Thromb. | pmid:16908950 |
Reilly CM et al. | The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. | 2008 | J. Autoimmun. | pmid:18650065 |
Hildmann C et al. | A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. | 2004 | J. Bacteriol. | pmid:15060035 |
Maruoka H et al. | Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons. | 2011 | J. Biochem. | pmid:21908547 |
Yamamoto I et al. | Histone hyperacetylation plays a role in augmentation of IL-4-induced IgE production in LPS-stimulated murine B-lymphocytes by sodium butyrate. | 1996 | J. Biochem. | pmid:8827437 |
Zhao W et al. | The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. | 2005 | J. Biochem. | pmid:15809347 |
Kook SH et al. | Epstein-Barr virus-infected Akata cells are sensitive to histone deacetylase inhibitor TSA-provoked apoptosis. | 2005 | J. Biochem. Mol. Biol. | pmid:16336792 |
Zhang Y and Zhang B | Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26509796 |
Jin B and Ryu DY | Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes. | 2004 | J. Biochem. Mol. Toxicol. | pmid:15252868 |
Tokési N et al. | TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. | 2010 | J. Biol. Chem. | pmid:20308065 |
Liou JS et al. | Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. | 2000 | J. Biol. Chem. | pmid:10967125 |
Wee G et al. | Inheritable histone H4 acetylation of somatic chromatins in cloned embryos. | 2006 | J. Biol. Chem. | pmid:16371357 |
Hsu MC et al. | HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. | 2006 | J. Biol. Chem. | pmid:16377629 |
Yang J et al. | A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. | 2010 | J. Biol. Chem. | pmid:20630860 |
Kurschat P et al. | Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. | 2006 | J. Biol. Chem. | pmid:16330548 |
Ooi L et al. | BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. | 2006 | J. Biol. Chem. | pmid:17023429 |
Topark-Ngarm A et al. | CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. | 2006 | J. Biol. Chem. | pmid:16950772 |
Sekimata M et al. | Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. | 2001 | J. Biol. Chem. | pmid:11553631 |
Kuno A et al. | Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein. | 2013 | J. Biol. Chem. | pmid:23297412 |
Musikacharoen T et al. | Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. | 2003 | J. Biol. Chem. | pmid:12511574 |
Dai X et al. | Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor. | 2010 | J. Biol. Chem. | pmid:20566633 |
Leu TH et al. | Participation of p97Eps8 in Src-mediated transformation. | 2004 | J. Biol. Chem. | pmid:14699156 |
Pagans S et al. | Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. | 2004 | J. Biol. Chem. | pmid:14701830 |
Hwang CK et al. | Transcriptional regulation of mouse mu opioid receptor gene by PU.1. | 2004 | J. Biol. Chem. | pmid:14998994 |
Kiefer SM et al. | Murine Sall1 represses transcription by recruiting a histone deacetylase complex. | 2002 | J. Biol. Chem. | pmid:11836251 |
Taniura S et al. | Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells. | 2002 | J. Biol. Chem. | pmid:11877441 |
Senawong T et al. | Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. | 2003 | J. Biol. Chem. | pmid:12930829 |
Ginjala V et al. | Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. | 2002 | J. Biol. Chem. | pmid:11777900 |
Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
Nam HJ et al. | Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. | 2010 | J. Biol. Chem. | pmid:20696758 |
Shan J et al. | ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. | 2012 | J. Biol. Chem. | pmid:22955275 |
Fu M et al. | p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. | 2000 | J. Biol. Chem. | pmid:10779504 |
Diamond SE and Gutierrez-Hartmann A | The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. | 2000 | J. Biol. Chem. | pmid:10921928 |
Spallotta F et al. | A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair. | 2013 | J. Biol. Chem. | pmid:23463510 |
Di-Poï N et al. | Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. | 2005 | J. Biol. Chem. | pmid:16166081 |
Chen CS et al. | Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. | 2005 | J. Biol. Chem. | pmid:16186112 |
Zschocke J et al. | Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells. | 2002 | J. Biol. Chem. | pmid:12138116 |
Ventura A et al. | The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. | 2002 | J. Biol. Chem. | pmid:11948181 |
Kang J et al. | Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. | 2000 | J. Biol. Chem. | pmid:10913161 |
Qian Y et al. | DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. | 2011 | J. Biol. Chem. | pmid:21317427 |
Shimazu T et al. | Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. | 2007 | J. Biol. Chem. | pmid:17172643 |
Ohoka N et al. | Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. | 2007 | J. Biol. Chem. | pmid:17872950 |
Tong X et al. | Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. | 2005 | J. Biol. Chem. | pmid:15713675 |
Gan Y et al. | Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. | 2005 | J. Biol. Chem. | pmid:15722551 |
Kijima M et al. | Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. | 1993 | J. Biol. Chem. | pmid:8226751 |
Zhang Y and Dufau ML | Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. | 2002 | J. Biol. Chem. | pmid:12091390 |
Gong XQ and Li L | Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. | 2002 | J. Biol. Chem. | pmid:11809751 |
Tominaga K et al. | MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. | 2003 | J. Biol. Chem. | pmid:14506250 |
Schuetz A et al. | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. | 2008 | J. Biol. Chem. | pmid:18285338 |
Gradin K et al. | Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt. | 1999 | J. Biol. Chem. | pmid:10224119 |
Agoulnik IU et al. | Repressors of androgen and progesterone receptor action. | 2003 | J. Biol. Chem. | pmid:12771131 |
Gray SG et al. | Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. | 2005 | J. Biol. Chem. | pmid:15927959 |
Asthana J et al. | Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells. | 2013 | J. Biol. Chem. | pmid:23798680 |
Wagner S et al. | SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. | 2006 | J. Biol. Chem. | pmid:16861234 |
Hayakawa K et al. | Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. | 2013 | J. Biol. Chem. | pmid:23625921 |
Tagami T et al. | Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor. | 1999 | J. Biol. Chem. | pmid:10428804 |
Fass DM et al. | Deacetylase activity is required for cAMP activation of a subset of CREB target genes. | 2003 | J. Biol. Chem. | pmid:12939274 |
Zhao C et al. | A composite motif of the Drosophila morphogenetic protein bicoid critical to transcription control. | 2003 | J. Biol. Chem. | pmid:12939280 |
Hinoi T et al. | Silencing of CDX2 expression in colon cancer via a dominant repression pathway. | 2003 | J. Biol. Chem. | pmid:12947088 |
Hichino A et al. | Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. | 2017 | J. Biol. Chem. | pmid:28057758 |
Frescas D et al. | Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. | 2005 | J. Biol. Chem. | pmid:15788402 |
Levenson JM et al. | Regulation of histone acetylation during memory formation in the hippocampus. | 2004 | J. Biol. Chem. | pmid:15273246 |
Arora T et al. | PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. | 2003 | J. Biol. Chem. | pmid:12716907 |