Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Qiang M et al. | Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:25522411 |
Wong CH et al. | CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. | 2014 | Oncogene | pmid:23542171 |
Li G et al. | Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue. | 2014 | J. Nutr. | pmid:25320182 |
Shi QQ et al. | Effect of trichostatin A on anti HepG2 liver carcinoma cells: inhibition of HDAC activity and activation of Wnt/β-Catenin signaling. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25292076 |
Wei N et al. | Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. | 2014 | Mol. Cell | pmid:25284223 |
An JH et al. | The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells. | 2014 | FEBS Lett. | pmid:25281925 |
Han RF et al. | Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. | 2014 | Mol Med Rep | pmid:25269990 |
Boucher J et al. | Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246545 |
Wang BY et al. | Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. | 2014 | Pharmacol. Biochem. Behav. | pmid:25242807 |
Wang B et al. | Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. | 2014 | Oncol. Rep. | pmid:25224651 |
Svegliati S et al. | Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. | 2014 | Sci Signal | pmid:25185156 |
Wilson-Edell KA et al. | RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. | 2014 | Oncotarget | pmid:24970821 |
Yang XL et al. | Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24969901 |
Hu Z and Wang J | Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells. | 2014 | Cell Reprogram | pmid:24945595 |
Ma H et al. | HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. | 2014 | Int J Mol Sci | pmid:24941254 |
Thangavel J et al. | Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. | 2014 | Am. J. Pathol. | pmid:24929240 |
Srirattana K et al. | Effects of trichostatin A on In vitro development and DNA methylation level of the satellite I region of swamp buffalo (Bubalus bubalis) cloned embryos. | 2014 | J. Reprod. Dev. | pmid:24909601 |
Wang Y et al. | Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. | 2014 | Int. J. Mol. Med. | pmid:24888454 |
Chan ST et al. | Oral and intraperitoneal administration of quercetin decreased lymphocyte DNA damage and plasma lipid peroxidation induced by TSA in vivo. | 2014 | Biomed Res Int | pmid:24868531 |
Kiliccioglu I et al. | Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines. | 2014 | Genet. Mol. Res. | pmid:24854658 |
Mathiyalagan P et al. | The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. | 2014 | Nucleic Acids Res. | pmid:24137001 |
Zhang YW et al. | Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. | 2014 | Epigenetics | pmid:24699858 |
Boyer JG et al. | Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. | 2014 | Hum. Mol. Genet. | pmid:24691550 |
Peiffer L et al. | Trichostatin A effectively induces apoptosis in chronic lymphocytic leukemia cells via inhibition of Wnt signaling and histone deacetylation. | 2014 | J. Cancer Res. Clin. Oncol. | pmid:24793644 |
Deneberg S et al. | microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. | 2014 | Epigenetics | pmid:24686393 |
Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
Zuo X et al. | Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. | 2014 | Oncol. Rep. | pmid:24676336 |
Balmer NV et al. | From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. | 2014 | Arch. Toxicol. | pmid:24935251 |
Aune SE et al. | Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. | 2014 | J. Mol. Cell. Cardiol. | pmid:24632412 |
Yuan TF et al. | The epigenetics changes in Parkinson's disease: a novel therapeutic target. | 2014 | CNS Neurosci Ther | pmid:24629108 |
Sun S et al. | Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells. | 2014 | PLoS ONE | pmid:24626188 |
Saayman S et al. | An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription. | 2014 | Mol. Ther. | pmid:24576854 |
McEachern LA and Murphy PR | Chromatin-remodeling factors mediate the balance of sense-antisense transcription at the FGF2 locus. | 2014 | Mol. Endocrinol. | pmid:24552587 |
Sakharkar AJ et al. | Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24528596 |
Kong Q et al. | Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer. | 2014 | Stem Cell Rev | pmid:24510582 |
Felisbino MB et al. | Changes in chromatin structure in NIH 3T3 cells induced by valproic acid and trichostatin A. | 2014 | J. Cell. Biochem. | pmid:24913611 |
Maleszewska M et al. | The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells. | 2014 | Pharmacol Rep | pmid:24905315 |
Fetahu IS et al. | Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. | 2014 | Int. J. Cancer | pmid:24691920 |
Saccone V et al. | HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. | 2014 | Genes Dev. | pmid:24682306 |
Alcarraz-Vizán G et al. | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. | 2014 | Biochim. Biophys. Acta | pmid:24368265 |
Xie M et al. | Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. | 2014 | Circulation | pmid:24396039 |
Koriyama Y et al. | Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. | 2014 | J. Pharmacol. Sci. | pmid:24389816 |
Johnson JL et al. | The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. | 2014 | J. Invest. Dermatol. | pmid:24594668 |
Chu Y et al. | Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. | 2014 | Cell. Mol. Life Sci. | pmid:24531693 |
Herr MJ et al. | Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24747564 |
Cheng X et al. | Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24747804 |
Guo J et al. | Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24763005 |
Blank M et al. | Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus. | 2014 | Neurobiol Learn Mem | pmid:24583371 |
Tran L et al. | Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. | 2013 | Psychoneuroendocrinology | pmid:23084728 |
Yeo M et al. | Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23440186 |