Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Strait KA et al. | Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. | 2002 | Mol. Cancer Ther. | pmid:12479699 |
Suenaga M et al. | Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. | 2002 | Int. J. Cancer | pmid:11807787 |
Fu M et al. | Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. | 2002 | Mol. Cell. Biol. | pmid:11971970 |
Quivy V et al. | Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. | 2002 | J. Virol. | pmid:12368351 |
Smith WL and Edlind TD | Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. | 2002 | Antimicrob. Agents Chemother. | pmid:12384361 |
Sourlingas TG et al. | The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. | 2002 Jan-Mar | Exp. Gerontol. | pmid:11772521 |
Iwata K et al. | Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470611 |
Noss KR et al. | Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. | 2002 May-Jun | Anticancer Res. | pmid:12168830 |
Rahman I et al. | Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. | 2002 May-Jun | Mol. Cell. Biochem. | pmid:12162440 |
Fernandes I et al. | Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. | 2003 | Mol. Cell | pmid:12535528 |
Cheutin T et al. | Maintenance of stable heterochromatin domains by dynamic HP1 binding. | 2003 | Science | pmid:12560555 |
Boutillier AL et al. | Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. | 2003 | J. Neurochem. | pmid:12562525 |
Tomita K et al. | The effect of oxidative stress on histone acetylation and IL-8 release. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565901 |
Kim Y et al. | Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. | 2003 | Oncogene | pmid:12584561 |
Mishra N et al. | Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. | 2003 | J. Clin. Invest. | pmid:12588892 |
Glaser KB et al. | Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. | 2003 | Mol. Cancer Ther. | pmid:12589032 |
Kondo Y et al. | Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. | 2003 | Mol. Cell. Biol. | pmid:12482974 |
Ding Z et al. | Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. | 2003 | Mol. Cell. Biol. | pmid:12482978 |
Obata T et al. | Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. | 2003 | Clin. Cancer Res. | pmid:14695142 |
Terui T et al. | Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. | 2003 | Cancer Res. | pmid:14695212 |
Liu A et al. | Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. | 2003 | Glia | pmid:14603467 |
Moreira JM et al. | The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. | 2003 | BMC Cancer | pmid:14606959 |
Remiszewski SW et al. | N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824). | 2003 | J. Med. Chem. | pmid:14521422 |
Ryu JR and Arnosti DN | Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. | 2003 | Nucleic Acids Res. | pmid:12888527 |
Pivot-Pajot C et al. | Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. | 2003 | Mol. Cell. Biol. | pmid:12861021 |
Grassi G et al. | Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. | 2003 | Carcinogenesis | pmid:12869421 |
Ammanamanchi S et al. | Acetylated sp3 is a transcriptional activator. | 2003 | J. Biol. Chem. | pmid:12837748 |
Krämer OH et al. | The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. | 2003 | EMBO J. | pmid:12840003 |
Kishikawa S et al. | Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. | 2003 | Nucleic Acids Res. Suppl. | pmid:14510503 |
Wegener D et al. | Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. | 2003 | Anal. Biochem. | pmid:14511685 |
Kim MS et al. | Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. | 2003 | Cancer Res. | pmid:14612526 |
Miller TA et al. | Histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14613312 |
Hitomi T et al. | p15(INK4b) in HDAC inhibitor-induced growth arrest. | 2003 | FEBS Lett. | pmid:14623092 |
Camarero N et al. | Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. | 2003 | Nucleic Acids Res. | pmid:12626711 |
Park KK et al. | Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788094 |
Marks J et al. | Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter. | 2003 | J. Biol. Chem. | pmid:12791684 |
Valls E et al. | The SV40 T antigen modulates CBP histone acetyltransferase activity. | 2003 | Nucleic Acids Res. | pmid:12799439 |
Ferguson M et al. | Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. | 2003 | Nucleic Acids Res. | pmid:12799440 |
Ji Y et al. | A multistep mechanism for the activation of rearrangement in the immune system. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12802019 |
Nemajerová A et al. | Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. | 2003 | J. Hematother. Stem Cell Res. | pmid:12804181 |
Park PH et al. | Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12804592 |
Kim H et al. | The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816733 |
Craig JM et al. | Centromeric chromatin pliability and memory at a human neocentromere. | 2003 | EMBO J. | pmid:12743043 |
Enright BP et al. | Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. | 2003 | Biol. Reprod. | pmid:12748129 |
Van Ommeslaeghe K et al. | Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12749885 |
Zhao S et al. | Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. | 2003 | Cancer Res. | pmid:12750289 |
Schauber J et al. | Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. | 2003 | Gut | pmid:12692061 |
Rambhatla L et al. | Generation of hepatocyte-like cells from human embryonic stem cells. | 2003 | Cell Transplant | pmid:12693659 |
Lee SC et al. | Activation of terminal B cell differentiation by inhibition of histone deacetylation. | 2003 | Mol. Immunol. | pmid:12695118 |
Chandler SP et al. | Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. | 2003 | BMC Mol. Biol. | pmid:12659659 |