Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tshuikina M et al. | Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. | 2008 | Exp. Hematol. | pmid:18922617 |
Liu F et al. | Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. | 2008 | J. Mol. Cell. Cardiol. | pmid:18926829 |
Bao Y et al. | Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. | 2009 | Atherosclerosis | pmid:18930459 |
Gu Z et al. | Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas. | 2008 | Genes Genet. Syst. | pmid:18931460 |
Bigl M et al. | Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18938139 |
Hayashi K et al. | Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. | 2008 | Cell Stem Cell | pmid:18940731 |
Ridolfi E et al. | Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. | 2008 | Br. J. Cancer | pmid:18941460 |
Katsura T et al. | The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells. | 2009 | Cancer Gene Ther. | pmid:18949013 |
Park H et al. | Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. | 2008 | Int. J. Mol. Med. | pmid:18949380 |
Lin YC et al. | Effects of trichostatin A on neuronal mu-opioid receptor gene expression. | 2008 | Brain Res. | pmid:18950606 |
Wallace DM and Cotter TG | Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina. | 2009 | J. Neurosci. Res. | pmid:18951482 |
Chittur SV et al. | Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | 2008 | BMC Genomics | pmid:18959802 |
Oger F et al. | The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18977200 |
Albertus DL et al. | AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. | 2008 | J Thorac Oncol | pmid:18978557 |
Chou CW and Chen CC | HDAC inhibition upregulates the expression of angiostatic ADAMTS1. | 2008 | FEBS Lett. | pmid:19007777 |
Hostetter CL et al. | Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. | 2009 | Cancer Lett. | pmid:19013015 |
Heo H et al. | Suppression of caspase-11 expression by histone deacetylase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013432 |
McCulloch MW et al. | Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. | 2009 | Bioorg. Med. Chem. | pmid:19022675 |
Noh EJ et al. | An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19038231 |
Kong X et al. | HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. | 2009 | J. Mol. Cell. Cardiol. | pmid:19041327 |
Setiadi AF et al. | Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. | 2008 | Cancer Res. | pmid:19047136 |
Mizumoto S et al. | The developmental potential of parthenogenetic and somatic cell nuclear-transferred rat oocytes in vitro. | 2008 | Cloning Stem Cells | pmid:19049415 |
Slack MD et al. | Characterizing heterogeneous cellular responses to perturbations. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19052231 |
Dowling DP et al. | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. | 2008 | Biochemistry | pmid:19053282 |
Gao J et al. | Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site. | 2009 | Glia | pmid:19062177 |
Ishii T et al. | [Epigenetic regulation in alcohol-related brain damage]. | 2008 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:19068777 |
Rossi M et al. | Caspase cleavage of Itch in chronic lymphocytic leukemia cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19073138 |
Gray SG et al. | Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. | 2008 | Clin Lung Cancer | pmid:19073520 |
Pollack BP et al. | Ultraviolet radiation-induced transcription is associated with gene-specific histone acetylation. | 2009 May-Jun | Photochem. Photobiol. | pmid:19076306 |
Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP]. | 2008 | Ai Zheng | pmid:19079988 |
Usami M et al. | Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. | 2008 | Nutr Res | pmid:19083427 |
Kishigami S and Wakayama T | Somatic cell nuclear transfer in the mouse. | 2009 | Methods Mol. Biol. | pmid:19085136 |
Jiang SJ et al. | [Effects of trichostatin A and paclitaxel on apoptosis and microtubule stabilization in endometrial carcinoma cells: an in vitro research]. | 2008 | Zhonghua Yi Xue Za Zhi | pmid:19087722 |
Azzi A et al. | Schistosoma mansoni: developmental arrest of miracidia treated with histone deacetylase inhibitors. | 2009 | Exp. Parasitol. | pmid:19094990 |
Hambach L et al. | Hypomethylating drugs convert HA-1-negative solid tumors into targets for stem cell-based immunotherapy. | 2009 | Blood | pmid:19096014 |
Sibinga NE | Stable protein, unstable plaque? | 2009 | J. Mol. Cell. Cardiol. | pmid:19101562 |
Niu F et al. | Trichostatin A enhances OGD-astrocyte viability by inhibiting inflammatory reaction mediated by NF-kappaB. | 2009 | Brain Res. Bull. | pmid:19103266 |
Santiago A et al. | Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions. | 2009 | Cell Cycle | pmid:19106612 |
Wang X et al. | Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes. | 2009 | Growth Factors | pmid:19107653 |
Trunzer M et al. | Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation. | 2009 | J. Med. Chem. | pmid:19108654 |
Smil DV et al. | Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19111466 |
Zhang S et al. | Effect of trichostatin a on viability and microRNA expression in human pancreatic cancer cell line BxPC-3. | 2008 | Exp. Oncol. | pmid:19112422 |
Kim TY et al. | Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. | 2008 | Exp. Mol. Med. | pmid:19116449 |
Cowell RM et al. | Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19118529 |
Wiesen JL and Tomasi TB | Dicer is regulated by cellular stresses and interferons. | 2009 | Mol. Immunol. | pmid:19118902 |
Togi S et al. | HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19121623 |
Dje N'Guessan P et al. | Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19122173 |
Zhou Q et al. | Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. | 2008 | Mol. Vis. | pmid:19122829 |
Yamada N et al. | Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. | 2009 | Br. J. Cancer | pmid:19127263 |
Giustiniani J et al. | Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53. | 2009 | Cell. Signal. | pmid:19136058 |
Chen Y et al. | 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. | 2009 | Eur J Med Chem | pmid:19136179 |
Glenn DJ et al. | Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. | 2009 | Hypertension | pmid:19139378 |
Li X and Bai XZ | [NF-kappaB modulates activation of the BMP-2 gene by trichostatin A]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140318 |
Kir'ianov GI et al. | [Nucleosome positioning within neomycinphosphotransferase gene (NPTII) on yeast plasmid in repressed and active state]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140324 |
Golyshev SA et al. | [The role of DNA methylation and histone modifications in structural maintainance of heterochromatin domains (chromocenters)]. | 2008 | Tsitologiia | pmid:19140344 |
Chen FQ et al. | Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea. | 2009 | J. Neurochem. | pmid:19141081 |
Zhao W et al. | Histone deacetylase inhibitor, trichostatin A, affects gene expression patterns during morphogenesis of chicken limb buds in vivo. | 2009 | Cells Tissues Organs (Print) | pmid:19147985 |
Chen Z et al. | BCL11A represses HBG transcription in K562 cells. | 2009 Mar-Apr | Blood Cells Mol. Dis. | pmid:19153051 |
Kekatpure VD et al. | HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. | 2009 | J. Biol. Chem. | pmid:19158084 |
Sutcliffe EL et al. | Dynamic histone variant exchange accompanies gene induction in T cells. | 2009 | Mol. Cell. Biol. | pmid:19158270 |
Bagui TK et al. | Inhibition of p27Kip1 gene transcription by mitogens. | 2009 | Cell Cycle | pmid:19158484 |
Chakravorty M et al. | IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. | 2009 | Int. J. Biochem. Cell Biol. | pmid:19166966 |
Sharma A et al. | Trichostatin a inhibits corneal haze in vitro and in vivo. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19168895 |
Zubia A et al. | Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. | 2009 | Oncogene | pmid:19169274 |
Yeh JR et al. | Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. | 2009 | Nat. Chem. Biol. | pmid:19172146 |
Wang L et al. | Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. | 2009 Mar-Apr | Immunol. Cell Biol. | pmid:19172156 |
Popova EY et al. | Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. | 2009 | Chromosome Res. | pmid:19172406 |
Tsuji Y et al. | The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2009 | Zygote | pmid:19175955 |
Gavin DP et al. | Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. | 2009 | J Psychiatr Res | pmid:19187942 |
Meng Q et al. | Live birth of somatic cell-cloned rabbits following trichostatin A treatment and cotransfer of parthenogenetic embryos. | 2009 | Cloning Stem Cells | pmid:19196041 |
Maalouf WE et al. | Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term. | 2009 | BMC Dev. Biol. | pmid:19210795 |
Sakurai T et al. | Induction of endogenous interferon tau gene transcription by CDX2 and high acetylation in bovine nontrophoblast cells. | 2009 | Biol. Reprod. | pmid:19211809 |
Deng G et al. | Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. | 2009 | Clin. Cancer Res. | pmid:19223499 |
Halaban R et al. | Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. | 2009 | PLoS ONE | pmid:19234609 |
Shao GB et al. | Effect of trychostatin A treatment on gene expression in cloned mouse embryos. | 2009 | Theriogenology | pmid:19246084 |
Zhang F et al. | Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. | 2009 | Cancer Biol. Ther. | pmid:19270532 |
Tan HH and Porter AG | p21(WAF1) negatively regulates DNMT1 expression in mammalian cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19275888 |
Mittal MK et al. | Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. | 2010 | Mol. Biol. Rep. | pmid:19277896 |
Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
Luo SF et al. | Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19281832 |
Giannini G et al. | N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19285395 |
Suo L et al. | Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development. | 2010 | Fertil. Steril. | pmid:19285668 |
Seo J et al. | Differential expression of stromal cell-derived factor 1 in human brain microvascular endothelial cells and pericytes involves histone modifications. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19289100 |
Cecconi D et al. | Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. | 2009 | Proteomics | pmid:19294695 |
Chen J et al. | E1A has no effect on LPS-induced IL-6 secretion in rat alveolar epithelial cells. | 2009 | Respiration | pmid:19299891 |
Ueda JY et al. | JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634. | 2009 | J. Antibiot. | pmid:19300468 |
Noro R et al. | The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application. | 2009 | J Nippon Med Sch | pmid:19305113 |
Patel V et al. | Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. | 2009 | J. Med. Chem. | pmid:19317450 |
GarcÃa-Villegas R et al. | Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na(x) gene (Scn7a). | 2009 | J. Neurosci. Res. | pmid:19326446 |
Derks S et al. | Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. | 2009 | Carcinogenesis | pmid:19329758 |
Liu X et al. | The improvement of adenovirus vector production by increased expression of coxsackie adenovirus receptor. | 2009 | Biotechnol. Lett. | pmid:19330491 |
Hollosi P et al. | Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. | 2009 | Int. J. Cancer | pmid:19330836 |
Yap OW et al. | Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells. | 2009 | Anticancer Res. | pmid:19331143 |
Yang X et al. | CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. | 2009 | PLoS ONE | pmid:19340297 |
Slattery EL et al. | Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. | 2009 | J. Assoc. Res. Otolaryngol. | pmid:19340485 |
Vilar E et al. | Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. | 2009 | Clin. Cancer Res. | pmid:19351759 |
Ikeda S et al. | Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts. | 2009 | Zygote | pmid:19356267 |
Morita K et al. | Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. | 2009 | J. Neurosci. Res. | pmid:19360904 |
von Burstin J et al. | E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. | 2009 | Gastroenterology | pmid:19362090 |
Cunneen TS et al. | In vitro effects of histone deacetylase inhibitors and mitomycin C on tenon capsule fibroblasts and conjunctival melanoma cells. | 2009 | Arch. Ophthalmol. | pmid:19365017 |