trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hosseinkhani M et al. | Trichostatin A induces myocardial differentiation of monkey ES cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17368572 |
| Dangond F and Gullans SR | Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647779 |
| Oger F et al. | The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18977200 |
| Ailenberg M and Silverman M | Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604329 |
| Takamatsu G et al. | Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27939885 |
| Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
| Maroni P et al. | Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23085045 |
| Higashi T et al. | Histone H2A mobility is regulated by its tails and acetylation of core histone tails. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17445770 |
| Gan Y et al. | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16338217 |
| Kishigami S et al. | Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16356478 |
| Ailenberg M and Silverman M | Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379227 |
| Ishimaru N et al. | Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20188708 |
| Rossi M et al. | Caspase cleavage of Itch in chronic lymphocytic leukemia cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19073138 |
| Noh EJ and Lee JS | Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2-M transition. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14521905 |
| Heo H et al. | Suppression of caspase-11 expression by histone deacetylase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013432 |
| Liu Z et al. | Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801101 |
| Bigl M et al. | Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18938139 |
| Jang SM et al. | Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916609 |
| Benny Klimek ME et al. | Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20036643 |
| Li H and Wu X | Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474507 |
| Nagaraja SS et al. | Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549Â cells. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28993195 |
| Choi HS et al. | Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12200149 |
| Yamamura A et al. | Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24134849 |
| Sayan BS et al. | Induction of TAp63 by histone deacetylase inhibitors. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20043870 |
| Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
| Ghosh AK et al. | Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17234156 |
| Nadanaka S et al. | Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751852 |
| Gray SG and Ekström TJ | Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9571167 |
| Maehara K et al. | Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12083788 |
| Wang XQ et al. | Histone deacetylase inhibition results in decreased macrophage CD9 expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12056820 |
| Carambula SF et al. | Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19665989 |
| Hejnar J et al. | Demethylation of host-cell DNA at the site of avian retrovirus integration. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14623319 |
| Park J et al. | ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22580278 |
| Hirose N et al. | ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19422799 |
| Brglez V et al. | Secreted phospholipases Aâ‚‚are differentially expressed and epigenetically silenced in human breast cancer cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24508801 |
| Ghosh AK et al. | MBP-1 physically associates with histone deacetylase for transcriptional repression. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403782 |
| Herr MJ et al. | Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24747564 |
| Hasegawa T et al. | Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10066455 |
| Inokoshi J et al. | Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079191 |
| Kim HS et al. | Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14651963 |
| Noh H et al. | Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26768368 |
| Kusakabe M et al. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19878646 |
| Liu J and Li Y | Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26436206 |
| Choi JH et al. | TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19914212 |
| Lu ZP et al. | Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15781251 |
| Iacobazzi V et al. | Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706393 |
| Liu J et al. | Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086099 |
| Gan Y et al. | Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:17996726 |
| Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |
| Hashii M et al. | Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17367762 |