Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lu L et al. | Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. | 2010 | J. Immunol. | pmid:20304828 |
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Tokési N et al. | TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. | 2010 | J. Biol. Chem. | pmid:20308065 |
Zhou Q et al. | TGFbeta mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylation. | 2010 | J. Cell. Physiol. | pmid:20232294 |
Chen WP et al. | Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. | 2010 | Mol. Biol. Rep. | pmid:20237852 |
Urbinati G et al. | Liposomes loaded with histone deacetylase inhibitors for breast cancer therapy. | 2010 | Int J Pharm | pmid:20603204 |
Sharma P et al. | Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells. | 2010 | Mol. Cancer | pmid:20609221 |
Mizutani H et al. | Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide. | 2010 | Cancer Sci. | pmid:20624163 |
Yang J et al. | A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. | 2010 | J. Biol. Chem. | pmid:20630860 |
Wang XH et al. | S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. | 2010 | Am. J. Pathol. | pmid:20581057 |
Terhune SS et al. | Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. | 2010 | PLoS Pathog. | pmid:20585571 |
Luo W et al. | Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer. | 2010 | Cancer Res. | pmid:20587525 |
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Li J et al. | Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. | 2010 | Autophagy | pmid:20543569 |
Vamadevan AS et al. | Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. | 2010 | Innate Immun | pmid:19710105 |
Kaichi S et al. | Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. | 2010 | Cardiovasc. Res. | pmid:20547733 |
Her S et al. | Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. | 2010 | J. Mol. Neurosci. | pmid:19728174 |
Yoshikawa M et al. | Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. | 2010 | Eur. J. Pharmacol. | pmid:20553909 |
Mousa SA et al. | Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. | 2010 | Cancer Lett. | pmid:19733430 |
Russell SB et al. | Epigenetically altered wound healing in keloid fibroblasts. | 2010 | J. Invest. Dermatol. | pmid:20555348 |
Repouskou A et al. | The circadian expression of c-MYC is modulated by the histone deacetylase inhibitor trichostatin A in synchronized murine neuroblastoma cells. | 2010 | Chronobiol. Int. | pmid:20560708 |
Tessema M et al. | Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. | 2010 | Oncogene | pmid:20562917 |
Kashiwagi Y et al. | Trichostatin A-induced TGF-beta type II receptor expression in retinoblastoma cell lines. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19737884 |
Kaimori A et al. | Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. | 2010 | Hepatology | pmid:20564330 |
Dai X et al. | Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor. | 2010 | J. Biol. Chem. | pmid:20566633 |
Sudo H and Baas PW | Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. | 2010 | J. Neurosci. | pmid:20505088 |
Yoshizawa Y et al. | Impaired active demethylation of the paternal genome in pronuclear-stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection. | 2010 | Mol. Reprod. Dev. | pmid:19743475 |
Bui HT et al. | Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos. | 2010 | Biol. Reprod. | pmid:20505166 |
Kim IA et al. | HDAC inhibitor-mediated radiosensitization in human carcinoma cells: a general phenomenon? | 2010 | J. Radiat. Res. | pmid:20505264 |
Chen J et al. | Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes. | 2010 | Epigenetics | pmid:20505343 |
Liu YW et al. | Inhibition of LPS-induced C/EBP delta by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells. | 2010 | J. Cell. Biochem. | pmid:20506344 |
Gay S et al. | Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions. | 2010 | EMBO Rep. | pmid:20671737 |
Okada T et al. | TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer. | 2010 | Genes Chromosomes Cancer | pmid:20140954 |
Shahabi S et al. | Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. | 2010 | Gynecol. Oncol. | pmid:20674962 |
Wessels I et al. | Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis. | 2010 | Immunology | pmid:20141541 |
Zhang C et al. | Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. | 2010 | J. Hepatol. | pmid:20675009 |
Swingler TE et al. | MMP28 gene expression is regulated by Sp1 transcription factor acetylation. | 2010 | Biochem. J. | pmid:20144149 |
Liu Z et al. | Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801101 |
Liu TY et al. | EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis. | 2010 | Mol. Cancer | pmid:20144199 |
Nam HJ et al. | Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. | 2010 | J. Biol. Chem. | pmid:20696758 |
Awe S and Renkawitz-Pohl R | Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster. | 2010 | Syst Biol Reprod Med | pmid:20170286 |
Jichan Nie SW et al. | Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent. | 2010 | Reprod Sci | pmid:20697142 |
Akiba Y et al. | Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20170631 |
Costa-Borges N et al. | Comparison between the effects of valproic acid and trichostatin A on the in vitro development, blastocyst quality, and full-term development of mouse somatic cell nuclear transfer embryos. | 2010 | Cell Reprogram | pmid:20698782 |
Angst E et al. | Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. | 2010 | Pancreas | pmid:20173668 |
Lee HS et al. | Enhanced histone acetylation in somatic cells induced by a histone deacetylase inhibitor improved inter-generic cloned leopard cat blastocysts. | 2010 | Theriogenology | pmid:20708232 |
Zhang L et al. | Histone deacetylase inhibitors attenuate acute lung injury during cecal ligation and puncture-induced polymicrobial sepsis. | 2010 | World J Surg | pmid:20177680 |
Tokoro M et al. | Deposition of acetylated histones by RNAP II promoter clearance may occur at onset of zygotic gene activation in preimplantation mouse embryos. | 2010 | J. Reprod. Dev. | pmid:20710121 |
Wu Y et al. | Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A. | 2010 | Gynecol. Obstet. Invest. | pmid:20130413 |
Torres J et al. | Biological effects of induced MYCN hyper-expression in MYCN-amplified neuroblastomas. | 2010 | Int. J. Oncol. | pmid:20811720 |
Zhao J et al. | Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. | 2010 | Cell Reprogram | pmid:20132015 |
Chuang C et al. | Acetylation of RNA processing proteins and cell cycle proteins in mitosis. | 2010 | J. Proteome Res. | pmid:20812760 |
Martinez-Diaz MA et al. | Pre- and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases. | 2010 | Cell Reprogram | pmid:20132016 |
Yang F et al. | Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize. | 2010 | BMC Plant Biol. | pmid:20718950 |
Host L et al. | Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. | 2010 | J. Neurochem. | pmid:20132486 |
Wu Y et al. | Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. | 2010 | BMC Cancer | pmid:20132554 |
Kim TH et al. | The histone deacetylase inhibitor, trichostatin A, inhibits the development of 2,4-dinitrofluorobenzene-induced dermatitis in NC/Nga mice. | 2010 | Int. Immunopharmacol. | pmid:20728595 |
Aoyama M et al. | Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. | 2010 | Nutrition | pmid:20004081 |
Ji P et al. | Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. | 2010 | Haematologica | pmid:20823130 |
Nunes MJ et al. | Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription. | 2010 | J. Neurochem. | pmid:20096088 |
Weng YI et al. | Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20678512 |
Wang J et al. | Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20089874 |
Hutt DM et al. | Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. | 2010 | Nat. Chem. Biol. | pmid:19966789 |
Islam NM et al. | Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20045316 |
Benny Klimek ME et al. | Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20036643 |
Peng CY et al. | Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines. | 2010 | Leuk. Lymphoma | pmid:20038232 |
Li RJ et al. | Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance. | 2010 | Ann. Oncol. | pmid:20038517 |
Nordén R et al. | Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression. | 2010 | Arch. Virol. | pmid:20039087 |
Emonds E et al. | Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells. | 2010 | World J. Gastroenterol. | pmid:20419833 |
Xu J et al. | CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors. | 2010 | Breast Cancer Res. Treat. | pmid:19466541 |
Sayan BS et al. | Induction of TAp63 by histone deacetylase inhibitors. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20043870 |
Tian F et al. | NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons. | 2010 | Amino Acids | pmid:19565326 |
Watson JA et al. | Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. | 2010 | J. Cell. Mol. Med. | pmid:19583812 |
Wang X et al. | Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells. | 2010 | Blood | pmid:20858855 |
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Liu YL et al. | Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma. | 2010 | Autophagy | pmid:20962572 |
McKenzie L et al. | p53-dependent repression of polo-like kinase-1 (PLK1). | 2010 | Cell Cycle | pmid:20962589 |
Mittal MK et al. | Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. | 2010 | Mol. Biol. Rep. | pmid:19277896 |
Zein S et al. | Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20975082 |
Chao KC et al. | Anti-tumor activity of histone deacetylase inhibitors and the effect on ATP-binding cassette in ovarian carcinoma cells. | 2010 | Eur. J. Gynaecol. Oncol. | pmid:20882882 |
MacTavish H et al. | Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. | 2010 | PLoS ONE | pmid:21283510 |
Varma A and Kwon-Chung KJ | Heteroresistance of Cryptococcus gattii to fluconazole. | 2010 | Antimicrob. Agents Chemother. | pmid:20385871 |
Yang H et al. | Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20404016 |
Lei L et al. | Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells. | 2010 | Chin. Med. Sci. J. | pmid:21232178 |
Wang G et al. | The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. | 2010 | Regen Med | pmid:20210581 |
Obier N et al. | Inhibition of histone deacetylases by Trichostatin A leads to a HoxB4-independent increase of hematopoietic progenitor/stem cell frequencies as a result of selective survival. | 2010 | Cytotherapy | pmid:20210674 |
Krishnan M et al. | HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. | 2010 | Oncogene | pmid:19881542 |
Trtková K et al. | Formation of AR-SMRT binding in prostate cancer cells treated with natural histone deacetylase inhibitor. | 2010 | Cancer Biomark | pmid:21178266 |
Ninios YP et al. | Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. | 2010 | Apoptosis | pmid:19882353 |
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Marumo T et al. | Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19906951 |
Yakovlev A et al. | Epigenetic regulation of caspase-3 gene expression in rat brain development. | 2010 | Gene | pmid:19909801 |
Zhao H et al. | New biomarkers probing depth of cell senescence assessed by laser scanning cytometry. | 2010 | Cytometry A | pmid:20939035 |
Wang L et al. | Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. | 2010 | Neuropsychopharmacology | pmid:20010550 |
Fernandez G and Zeichner SL | Cell line-dependent variability in HIV activation employing DNMT inhibitors. | 2010 | Virol. J. | pmid:20942961 |
Lee CS et al. | Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines. | 2010 | Mol. Cell. Biochem. | pmid:20020183 |
Ibanez de Caceres I et al. | IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. | 2010 | Oncogene | pmid:20023704 |
Kuribayashi T et al. | Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. | 2010 | Int. J. Mol. Med. | pmid:19956898 |
Hui KF and Chiang AK | Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death. | 2010 | Int. J. Cancer | pmid:19816947 |
Li X et al. | Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. | 2010 | Br. J. Haematol. | pmid:19807731 |