| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Biliary Tract Neoplasms | D001661 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Cat Diseases | D002371 | 12 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chuang HC et al. | Histone deacetylase 3 binds to and regulates the GCMa transcription factor. | 2006 | Nucleic Acids Res. | pmid:16528103 |
| Vinken M et al. | Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. | 2006 | Toxicol. Sci. | pmid:16531468 |
| Gastaldi T et al. | Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation. | 2006 | Carcinogenesis | pmid:16537559 |
| Tada Y et al. | Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. | 2006 | J. Natl. Cancer Inst. | pmid:16537832 |
| Bishop CL et al. | Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA. | 2006 | Mol. Cell. Biol. | pmid:16537904 |
| Hsiao CH et al. | Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species. | 2006 | Exp. Hematol. | pmid:16543060 |
| Gagnon JF et al. | Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. | 2006 | Clin. Cancer Res. | pmid:16551870 |
| Rebbaa A et al. | The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. | 2006 | Cell Death Differ. | pmid:16557274 |
| Lund P et al. | Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. | 2006 | Oncogene | pmid:16568090 |
| Piacentini P et al. | Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. | 2006 | Virchows Arch. | pmid:16568310 |
| Woo HJ et al. | Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells. | 2007 | Exp. Mol. Pathol. | pmid:16574101 |
| Nusinzon I and Horvath CM | Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. | 2006 | Mol. Cell. Biol. | pmid:16581785 |
| Stefanovsky V and Moss T | Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count. | 2006 | Cell Cycle | pmid:16582637 |
| Wang Q et al. | Histone deacetylation is required for orderly meiosis. | 2006 | Cell Cycle | pmid:16582639 |
| Jaalouk DE et al. | Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. | 2006 | Virol. J. | pmid:16603064 |
| Banwell CM et al. | Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. | 2006 | Clin. Cancer Res. | pmid:16609009 |
| Januchowski R et al. | Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. | 2007 | Cancer Lett. | pmid:16624484 |
| Magnaghi-Jaulin L and Jaulin C | Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis. | 2006 | Chromosome Res. | pmid:16628502 |
| Pavan Kumar P et al. | Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. | 2006 | Mol. Cell | pmid:16630892 |
| Uchida H et al. | Human endometrial cytodifferentiation by histone deacetylase inhibitors. | 2006 | Hum. Cell | pmid:16643606 |
| Jung EJ et al. | Lytic induction and apoptosis of Epstein-Barr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir. | 2007 | Cancer Lett. | pmid:16647201 |
| Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
| Hernandez M et al. | A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. | 2006 | Prostate | pmid:16652385 |
| Armstrong K et al. | NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. | 2006 | Prostate | pmid:16683270 |
| Wischnewski F et al. | Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. | 2006 | Mol. Cancer Res. | pmid:16687489 |
| Ibanez de Caceres I et al. | Identification of novel target genes by an epigenetic reactivation screen of renal cancer. | 2006 | Cancer Res. | pmid:16707423 |
| Imre G et al. | Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. | 2006 | Cancer Res. | pmid:16707469 |
| Nygård M et al. | Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. | 2006 | J. Mol. Endocrinol. | pmid:16720720 |
| Yamada N et al. | MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. | 2006 | Int. J. Cancer | pmid:16721789 |
| Kim Y et al. | Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. | 2006 | J. Steroid Biochem. Mol. Biol. | pmid:16723222 |
| Santander VS et al. | Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. | 2006 | Mol. Cell. Biochem. | pmid:16733802 |
| Kong Y et al. | Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. | 2006 | Circulation | pmid:16735673 |
| Dannenberg LO et al. | Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. | 2006 | Alcohol. Clin. Exp. Res. | pmid:16737450 |
| Cabrero JR et al. | Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. | 2006 | Mol. Biol. Cell | pmid:16738306 |
| Vulcano F et al. | HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. | 2006 | Exp. Cell Res. | pmid:16739251 |
| Qi H and Ratnam M | Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. | 2006 | Cancer Res. | pmid:16740727 |
| Rouhi A et al. | Plasticity of Ly49g expression is due to epigenetics. | 2007 | Mol. Immunol. | pmid:16750269 |
| Morinobu A et al. | Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. | 2006 | J. Rheumatol. | pmid:16755652 |
| Kwon HS et al. | Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. | 2006 Mar-Apr | Biochim. Biophys. Acta | pmid:16757381 |
| Vanniasinkam T et al. | Trichostatin-A enhances adaptive immune responses to DNA vaccination. | 2006 | J. Clin. Virol. | pmid:16765083 |
| Li GC et al. | Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. | 2006 | Int. J. Urol. | pmid:16771729 |
| Zhou C et al. | Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. | 2006 | Int. J. Oncol. | pmid:16773209 |
| Tsuji H et al. | Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice. | 2006 | Plant Cell Physiol. | pmid:16774928 |
| Kwon O et al. | NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells. | 2006 | Carcinogenesis | pmid:16774937 |
| Zhao YM et al. | Effects of histone deacetylase inhibitors on transcriptional regulation of the hsp70 gene in Drosophila. | 2006 | Cell Res. | pmid:16775628 |
| Sharma D et al. | Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. | 2006 | Cancer Res. | pmid:16778215 |
| Wu Y and Guo SW | Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. | 2006 | Gynecol. Obstet. Invest. | pmid:16778450 |
| Iacomino G et al. | Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line. | 2006 | J. Cell. Biochem. | pmid:16795040 |
| Suuronen T et al. | Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia. | 2006 | Neurochem. Int. | pmid:16797784 |
| Wallace DM et al. | Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16799012 |