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Ann. Thorac. Surg. |
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High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. |
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Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. |
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Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes. |
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Reproduction |
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Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. |
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Int. J. Radiat. Oncol. Biol. Phys. |
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Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. |
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Oncol. Rep. |
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Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. |
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Mol. Cancer |
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HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. |
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Cancer Res. |
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Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. |
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Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. |
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Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies. |
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Am. J. Hum. Genet. |
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Oncogene |
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BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. |
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Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis? |
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Mol. Cancer Res. |
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B29 gene silencing in pituitary cells is regulated by its 3' enhancer. |
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Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. |
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Nat. Chem. Biol. |
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CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. |
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A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. |
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Genes Dev. |
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Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. |
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Dev. Biol. |
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Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. |
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Mol. Cell. Probes |
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Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. |
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Biochem. Biophys. Res. Commun. |
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Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. |
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Mol. Biol. Cell |
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Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. |
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J. Med. Chem. |
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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. |
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Mol. Cell. Biol. |
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Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. |
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Biochem. Biophys. Res. Commun. |
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Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. |
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Endocr. Relat. Cancer |
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TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome. |
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Cancer Biol. Ther. |
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[Basic research for renal regeneration]. |
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Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells. |
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Neurosci. Lett. |
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Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. |
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J. Neurochem. |
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Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. |
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Histone deacetylase 3 binds to and regulates the GCMa transcription factor. |
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Nucleic Acids Res. |
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Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species. |
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Exp. Hematol. |
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Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. |
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Virchows Arch. |
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Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. |
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J. Cell. Physiol. |
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Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. |
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Proc. Natl. Acad. Sci. U.S.A. |
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A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. |
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Prostate |
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Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. |
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FASEB J. |
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Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. |
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Biol. Chem. |
pmid:16800739
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Wang Y et al. |
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. |
2006 |
Arthritis Rheum. |
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Morinobu A et al. |
Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. |
2006 |
J. Rheumatol. |
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Involvement of caspase activation and mitochondrial stress in trichostatin A-induced apoptosis of Burkitt's lymphoma cell line, Akata. |
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RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. |
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Cancer Res. |
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The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. |
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Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. |
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Cancer Res. |
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Estrogen receptor-alpha methylation predicts melanoma progression. |
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Cancer Res. |
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Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. |
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Int. J. Oncol. |
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Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice. |
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Plant Cell Physiol. |
pmid:16774928
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Kwon O et al. |
NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells. |
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Carcinogenesis |
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Effects of histone deacetylase inhibitors on transcriptional regulation of the hsp70 gene in Drosophila. |
2006 |
Cell Res. |
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Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. |
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Cancer Res. |
pmid:16778215
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Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. |
2006 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:16234266
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Wu Y and Guo SW |
Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. |
2006 |
Gynecol. Obstet. Invest. |
pmid:16778450
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Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line. |
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Trichostatin-A enhances adaptive immune responses to DNA vaccination. |
2006 |
J. Clin. Virol. |
pmid:16765083
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Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. |
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Cancer Res. |
pmid:16740727
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Nusinzon I and Horvath CM |
Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. |
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Mol. Cell. Biol. |
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Identification of novel target genes by an epigenetic reactivation screen of renal cancer. |
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Cancer Res. |
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Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. |
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Cancer Res. |
pmid:16707469
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Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. |
2006 |
Virol. J. |
pmid:16603064
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Lu Z et al. |
E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. |
2006 |
Oncogene |
pmid:16158053
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Hwang DY and Ismail-Beigi F |
Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. |
2006 |
Am. J. Physiol., Cell Physiol. |
pmid:16162661
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In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. |
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Cancer Gene Ther. |
pmid:16167063
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Yu Z and Kone BC |
Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. |
2006 |
Am. J. Physiol. Renal Physiol. |
pmid:16174862
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Kim MY et al. |
Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. |
2006 |
Mol. Endocrinol. |
pmid:16497729
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Leng Y and Chuang DM |
Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. |
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J. Neurosci. |
pmid:16837598
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Aung HT et al. |
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. |
2006 |
FASEB J. |
pmid:16816106
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Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells. |
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Mol. Cancer Ther. |
pmid:17172411
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Kozłowska A and Jagodziński PP |
Effect of Trichostatin A on CD4 surface density in peripheral blood T cells. |
2006 |
Folia Histochem. Cytobiol. |
pmid:17219719
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Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells. |
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J. Huazhong Univ. Sci. Technol. Med. Sci. |
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Trichostatin A regulates hGCN5 expression and cell cycle on Daudi cells in vitro. |
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J. Huazhong Univ. Sci. Technol. Med. Sci. |
pmid:17219960
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[Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. |
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Ai Zheng |
pmid:16965673
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Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. |
2006 |
Clin. Cancer Res. |
pmid:16609009
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Ryu JK et al. |
SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. |
2006 |
Cancer Lett. |
pmid:16009488
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Wang Q et al. |
Histone phosphorylation and pericentromeric histone modifications in oocyte meiosis. |
2006 |
Cell Cycle |
pmid:16969090
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Karvonen U et al. |
Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. |
2006 |
Exp. Cell Res. |
pmid:16860317
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Wagner S et al. |
SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. |
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J. Biol. Chem. |
pmid:16861234
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Zhang X et al. |
Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. |
2006 |
Oncol. Rep. |
pmid:16865256
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Villanueva R et al. |
Histone deacetylase 3 represses HTLV-1 tax transcription. |
2006 |
Oncol. Rep. |
pmid:16865259
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Kim TY et al. |
Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. |
2006 |
Cancer Res. |
pmid:16885346
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Kimura N et al. |
Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. |
2006 |
Protist |
pmid:16839811
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Monte M et al. |
MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16847267
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Zaveri NT et al. |
Regulation of the prepronociceptin gene and its effect on neuronal differentiation. |
2006 |
Gene |
pmid:16935438
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Dokras A et al. |
Epigenetic regulation of maspin expression in the human placenta. |
2006 |
Mol. Hum. Reprod. |
pmid:16936308
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Yamamura K et al. |
Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis. |
2006 |
Br. J. Haematol. |
pmid:16939493
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Das PM et al. |
Methylation mediated silencing of TMS1/ASC gene in prostate cancer. |
2006 |
Mol. Cancer |
pmid:16848908
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Puppin C et al. |
HEX expression and localization in normal mammary gland and breast carcinoma. |
2006 |
BMC Cancer |
pmid:16854221
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Dannenberg LO and Edenberg HJ |
Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. |
2006 |
BMC Genomics |
pmid:16854234
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Bell CW et al. |
The extracellular release of HMGB1 during apoptotic cell death. |
2006 |
Am. J. Physiol., Cell Physiol. |
pmid:16855214
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Olaharski AJ et al. |
The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro. |
2006 |
Toxicol. Sci. |
pmid:16857700
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Lund P et al. |
Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. |
2006 |
Oncogene |
pmid:16568090
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Piacentini P et al. |
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. |
2006 |
Virchows Arch. |
pmid:16568310
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Alao JP et al. |
The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. |
2006 |
Mol. Cancer |
pmid:16503970
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Alao JP et al. |
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. |
2006 |
Mol. Cancer |
pmid:16504004
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Ostapkowicz A et al. |
Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. |
2006 |
Mol. Cancer Ther. |
pmid:16505096
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Hellebrekers DM et al. |
Angiostatic activity of DNA methyltransferase inhibitors. |
2006 |
Mol. Cancer Ther. |
pmid:16505122
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Kong X et al. |
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. |
2006 |
Mol. Cell. Biol. |
pmid:16507982
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