| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenocarcinoma, Papillary | D000231 | 2 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Biliary Tract Neoplasms | D001661 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Cat Diseases | D002371 | 12 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sasaki Y et al. | p53 negatively regulates the hepatoma growth factor HDGF. | 2011 | Cancer Res. | pmid:22006999 |
| Aoyama K et al. | Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. | 2011 | Exp. Cell Res. | pmid:22001646 |
| Jeon HG et al. | Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. | 2011 | J. Urol. | pmid:21944112 |
| Sanders YY et al. | Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20724553 |
| Zhou S et al. | Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. | 2011 | Circ. Res. | pmid:21778425 |
| Sar P et al. | 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. | 2011 | PLoS ONE | pmid:21687737 |
| Cosner CC and Helquist P | Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. | 2011 | Org. Lett. | pmid:21688856 |
| Kojima S et al. | Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. | 2011 | Plant Cell Physiol. | pmid:21700721 |
| Chik CL et al. | Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes. | 2011 | Mol. Cell. Endocrinol. | pmid:21704117 |
| Zhang L et al. | ABA treatment of germinating maize seeds induces VP1 gene expression and selective promoter-associated histone acetylation. | 2011 | Physiol Plant | pmid:21679193 |
| Lin S et al. | HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells. | 2011 | Curr. HIV Res. | pmid:21631428 |
| Jugová A et al. | Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. | 2011 | Cell Biol. Int. | pmid:21635225 |
| Wong CY et al. | Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. | 2011 | J. Biol. Chem. | pmid:21636851 |
| Shi G et al. | The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells. | 2011 | J. Cell. Physiol. | pmid:21321941 |
| Fan Y et al. | Derivation of cloned human blastocysts by histone deacetylase inhibitor treatment after somatic cell nuclear transfer with β-thalassemia fibroblasts. | 2011 | Stem Cells Dev. | pmid:21322785 |
| Kim YJ et al. | Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos. | 2011 | In Vitro Cell. Dev. Biol. Anim. | pmid:21359816 |
| Jang ER et al. | Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. | 2011 | Mol. Cell. Biochem. | pmid:21380726 |
| Fan T et al. | EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. | 2011 | Mol. Cancer Res. | pmid:21383005 |
| Yang J et al. | [Study of RASSF1A expression and promoter demethylation in Hep-2 cell line]. | 2011 | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:21473137 |
| Cui XS et al. | Trichostatin A modulates apoptotic-related gene expression and improves embryo viability in cloned bovine embryos. | 2011 | Cell Reprogram | pmid:21473694 |
| Chen X et al. | Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents. | 2011 | Molecules | pmid:22048700 |
| Sun JY et al. | Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia. | 2011 | Clin Lymphoma Myeloma Leuk | pmid:21454220 |
| Kong QR et al. | [TSA improve transgenic porcine cloned embryo development and transgene expression]. | 2011 | Yi Chuan | pmid:22049689 |
| Min XJ et al. | Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21454376 |
| Belakavadi M et al. | Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. | 2011 | Mol. Cell. Endocrinol. | pmid:21458529 |
| Dávalos-Salas M et al. | Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. | 2011 | BMC Cancer | pmid:21663659 |
| El-Serafi AT et al. | Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A. | 2011 | Differentiation | pmid:20970916 |
| Zhang FQ et al. | Cell-cycle-dependent variations in the FTIR spectroscopy of HeLa cells treated with trichostatin A. | 2011 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:22007388 |
| da Costa Prando E et al. | Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. | 2011 | Epigenetics | pmid:22139571 |
| Nagamine MK et al. | In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor. | 2011 | Vet. Res. Commun. | pmid:21472452 |
| Maruoka H et al. | Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons. | 2011 | J. Biochem. | pmid:21908547 |
| Biermann J et al. | Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells. | 2011 | Mol. Vis. | pmid:21311741 |
| Li S et al. | Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. | 2011 | Mol. Cancer | pmid:21314984 |
| Akagi S et al. | Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos. | 2011 | J. Reprod. Dev. | pmid:20962457 |
| Mayor R et al. | Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. | 2011 | Epigenetics | pmid:21852760 |
| Kumar A et al. | γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. | 2011 | Int. J. Radiat. Biol. | pmid:21815748 |
| Tan L et al. | Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells. | 2011 | Cancer | pmid:20925046 |
| Jackson K et al. | Epigenetic silencing of somatostatin in gastric cancer. | 2011 | Dig. Dis. Sci. | pmid:20927589 |
| Sahu GK and Cloyd MW | Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors. | 2011 | Virol. J. | pmid:21838863 |
| Yu D et al. | Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21840716 |
| Atanackovic D et al. | Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. | 2011 | Am. J. Hematol. | pmid:21898529 |
| Paterson S et al. | Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. | 2011 | Drug Metab. Dispos. | pmid:20870783 |
| Wang JP et al. | Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. | 2011 | PLoS ONE | pmid:21901157 |
| Pianta A et al. | Nucleophosmin delocalization in thyroid tumour cells. | 2011 | Endocr. Pathol. | pmid:21258971 |
| Yin H et al. | Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. | 2011 | Mol. Biol. Rep. | pmid:21181272 |
| Stoppani E et al. | Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature. | 2011 | Biochim. Biophys. Acta | pmid:21182936 |
| Puppin C et al. | Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. | 2011 | Oncol. Rep. | pmid:21152868 |
| Tsai PF et al. | Interplay between PKCδ and Sp1 on histone deacetylase inhibitor-mediated Epstein-Barr virus reactivation. | 2011 | J. Virol. | pmid:21159880 |
| Nandakumar V et al. | (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. | 2011 | Carcinogenesis | pmid:21209038 |
| Kang H and Roh S | Extended exposure to trichostatin A after activation alters the expression of genes important for early development in nuclear transfer murine embryos. | 2011 | J. Vet. Med. Sci. | pmid:21187677 |