trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ji Z et al. | Integrating genomics and proteomics data to predict drug effects using binary linear programming. | 2014 | PLoS ONE | pmid:25036040 |
| Lv W et al. | Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. | 2014 | PLoS ONE | pmid:25412078 |
| Lu HK et al. | Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. | 2014 | PLoS ONE | pmid:25409334 |
| Yang W et al. | Effect of trichostatin A on gelsolin levels, proteolysis of amyloid precursor protein, and amyloid beta-protein load in the brain of transgenic mouse model of Alzheimer's disease. | 2014 | Curr Alzheimer Res | pmid:25387339 |
| Ying H et al. | Pressure overload-induced cardiac hypertrophy response requires janus kinase 2-histone deacetylase 2 signaling. | 2014 | Int J Mol Sci | pmid:25380525 |
| Nishida N et al. | Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking. | 2014 | Dig Dis | pmid:25376292 |
| Quan H et al. | Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. | 2014 | Oncogene | pmid:23770846 |
| Saini M et al. | Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro. | 2014 | Theriogenology | pmid:25151601 |
| Tomioka T et al. | The histone deacetylase inhibitor trichostatin A induces neurite outgrowth in PC12 cells via the epigenetically regulated expression of the nur77 gene. | 2014 | Neurosci. Res. | pmid:25128386 |
| Zhang Q et al. | Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis. | 2014 | Cancer Lett. | pmid:25109451 |
| Helm D et al. | Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics. | 2014 | Mol. Cell Proteomics | pmid:25106551 |
| Yoshida T et al. | Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity. | 2014 | J. Biol. Chem. | pmid:25100730 |
| Dubois-Pot-Schneider H et al. | Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. | 2014 | Hepatology | pmid:25098666 |
| Wu TH et al. | Melatonin prevents neonatal dexamethasone induced programmed hypertension: histone deacetylase inhibition. | 2014 | J. Steroid Biochem. Mol. Biol. | pmid:25090636 |
| Shi Q et al. | [Inhibitory effect of trichostatin A on HepG2 cell proliferation and the mechanisms]. | 2014 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:25057056 |
| Tsuji M et al. | Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation. | 2014 | J. Pharmacol. Sci. | pmid:25048113 |
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| Sun DF et al. | Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. | 2014 | Cell Biol. Int. | pmid:24030871 |
| Skoge RH et al. | Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. | 2014 | DNA Repair (Amst.) | pmid:24814981 |
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| Guo W et al. | Aberrant methylation and decreased expression of the TGF-β/Smad target gene FBXO32 in esophageal squamous cell carcinoma. | 2014 | Cancer | pmid:24798237 |
| Palii CG et al. | Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes. | 2014 | Cell Stem Cell | pmid:24792117 |
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| Rafehi H et al. | Vascular histone deacetylation by pharmacological HDAC inhibition. | 2014 | Genome Res. | pmid:24732587 |
| Hassan MK et al. | Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. | 2014 | PLoS ONE | pmid:24728004 |
| Drela K et al. | Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. | 2014 | Cytotherapy | pmid:24726658 |
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| Song BS et al. | Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. | 2014 | Reprod. Fertil. Dev. | pmid:23506644 |
| Fang J et al. | Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy. | 2014 | Neurol. Sci. | pmid:23925573 |
| Xie L et al. | Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFβ2-induced lens epithelial-to-mesenchymal cell transition. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:24994865 |
| Bitman M et al. | Valproate activates ERK signaling pathway in primary human hepatocytes. | 2014 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23073524 |
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| Sassi Fde A et al. | Inhibitory activities of trichostatin a in U87 glioblastoma cells and tumorsphere-derived cells. | 2014 | J. Mol. Neurosci. | pmid:24464841 |
| Li H et al. | The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte. | 2014 | Plant Cell | pmid:24464291 |
| Xiao W et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. | 2014 | J. Cell. Mol. Med. | pmid:24456602 |
| Oride A et al. | Trichostatin A specifically stimulates gonadotropin FSHβ gene expression in gonadotroph LβT2 cells. | 2014 | Endocr. J. | pmid:24430728 |
| Sugimoto K et al. | Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors. | 2014 | Transpl. Int. | pmid:24410777 |
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| Jin YX et al. | Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro. | 2014 | Reprod. Fertil. Dev. | pmid:23759302 |
| Yang W et al. | Trichostatin A increases the levels of plasma gelsolin and amyloid beta-protein in a transgenic mouse model of Alzheimer's disease. | 2014 | Life Sci. | pmid:24486299 |
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| Smith S et al. | Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. | 2014 | PLoS ONE | pmid:24466340 |
| Chen HY et al. | Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. | 2014 | Pharmazie | pmid:24601225 |
| Kilinc V et al. | Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism? | 2014 | Tumour Biol. | pmid:24622883 |
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| Barr MP et al. | VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach. | 2015 | Epigenomics | pmid:26479311 |
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