Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Peng L et al. | Epigenetic inactivation of ADAMTS9 via promoter methylation in multiple myeloma. | 2013 | Mol Med Rep | pmid:23358566 |
Corvetta D et al. | Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. | 2013 | J. Biol. Chem. | pmid:23362253 |
Sato T et al. | Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. | 2013 | PLoS ONE | pmid:23555753 |
Mateen S et al. | Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23461975 |
Hansberg-Pastor V et al. | The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. | 2013 | Steroids | pmid:23474171 |
Arora DS et al. | Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. | 2013 | Neuropsychopharmacology | pmid:23474591 |
Lee AR et al. | Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes. | 2013 | J. Reprod. Dev. | pmid:23474603 |
Lee MS et al. | Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response. | 2013 | Cell Death Differ. | pmid:23238566 |
Kamiya H et al. | Enhanced transgene expression from chromatinized plasmid DNA in mouse liver. | 2013 | Int J Pharm | pmid:23247018 |
Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
Mehdi O et al. | HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). | 2012 Mar-Apr | Pancreatology | pmid:22487525 |
Srirattana K et al. | Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22578161 |
Truong M et al. | Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence. | 2012 | Br. J. Cancer | pmid:22596233 |
Hsu DW et al. | Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. | 2012 | Nucleic Acids Res. | pmid:22600736 |
Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
Balsas P et al. | Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. | 2012 | Leuk. Res. | pmid:21978467 |
Deckmann K et al. | Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. | 2012 | Cell. Signal. | pmid:21983014 |
Hoque MA et al. | Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23021104 |
Zhang L et al. | Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts. | 2012 | J. Biol. Chem. | pmid:23024362 |
Merschbaecher K et al. | Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation. | 2012 | PLoS ONE | pmid:23028801 |
Zhao ZN et al. | TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC. | 2012 | PLoS ONE | pmid:23028803 |
Banik D et al. | Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. | 2012 | PLoS ONE | pmid:23028998 |
Wang HF et al. | Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice. | 2012 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:22992439 |
Ma J et al. | Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. | 2012 | Int. J. Mol. Med. | pmid:22992863 |
Shi YL et al. | Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. | 2012 | J. Dermatol. Sci. | pmid:22999682 |
Tomosugi M et al. | Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. | 2012 | Cancer Sci. | pmid:22957647 |
Zhai FX et al. | RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22179198 |
Sancho-Pelluz J and Paquet-Durand F | HDAC inhibition prevents Rd1 mouse photoreceptor degeneration. | 2012 | Adv. Exp. Med. Biol. | pmid:22183322 |
Chen H et al. | LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. | 2012 | Cancer Lett. | pmid:22743615 |
Vadnal J et al. | Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. | 2012 | Exp Brain Res | pmid:22811216 |
Lin KT et al. | HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. | 2012 | Clin. Cancer Res. | pmid:22811583 |
Sangalli JR et al. | Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle. | 2012 | Cell Reprogram | pmid:22468998 |
Zhang S et al. | [Effect of trichostatin A and paclitaxel on the growth and apoptosis of lung adenocarcinoma cell lines]. | 2012 | Zhonghua Zhong Liu Za Zhi | pmid:22967465 |
Yamamura N and Kishimoto T | Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma. | 2012 | Exp. Mol. Pathol. | pmid:22472323 |
Zhang HN et al. | Endogenous glucocorticoids inhibit myocardial inflammation induced by lipopolysaccharide: involvement of regulation of histone deacetylation. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22472906 |
Qin ZX et al. | [Effect of TSA and VPA treatment on long-tailed macaque (Macaca fascicularis)-pig interspecies somatic cell nuclear transfer]. | 2012 | Yi Chuan | pmid:22425953 |
Zhou X et al. | Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22425986 |
Fleiss B et al. | Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. | 2012 | J Neuroinflammation | pmid:22512781 |
Zhu K et al. | Expression characterization and the promoter activity analysis of zebrafish hdac4. | 2012 | Fish Physiol. Biochem. | pmid:21773810 |
Ikehata M et al. | Different involvement of DNA methylation and histone deacetylation in the expression of solute-carrier transporters in 4 colon cancer cell lines. | 2012 | Biol. Pharm. Bull. | pmid:22382314 |
Andrews KT et al. | Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. | 2012 | PLoS ONE | pmid:22384084 |
Zhu S et al. | TSA-induced JMJD2B downregulation is associated with cyclin B1-dependent survivin degradation and apoptosis in LNCap cells. | 2012 | J. Cell. Biochem. | pmid:22388778 |
Usui T et al. | HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22389387 |
Wang H et al. | Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells. | 2012 | J Neural Transm | pmid:22407380 |
Yang PM et al. | CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1. | 2012 | Epigenetics | pmid:22419072 |
Wang C et al. | Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. | 2012 | Diabetes Metab. Res. Rev. | pmid:22228707 |
Gupta K et al. | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | 2012 | PLoS ONE | pmid:23285096 |