trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kawamura T et al. | Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. | 2005 | J. Biol. Chem. | pmid:15764815 |
| Dote H et al. | Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. | 2005 | Br. J. Cancer | pmid:15770214 |
| Laberge RM and Boissonneault G | On the nature and origin of DNA strand breaks in elongating spermatids. | 2005 | Biol. Reprod. | pmid:15772260 |
| McKenzie GJ et al. | Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. | 2005 | J. Neurochem. | pmid:15773917 |
| Subramanian C et al. | Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15778293 |
| Lu ZP et al. | Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15781251 |
| Nishigaki M et al. | Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. | 2005 | Cancer Res. | pmid:15781621 |
| Bai J et al. | Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. | 2005 | Cancer Res. | pmid:15781649 |
| Rahmani M et al. | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. | 2005 | Cancer Res. | pmid:15781658 |
| Frescas D et al. | Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. | 2005 | J. Biol. Chem. | pmid:15788402 |
| Li X et al. | Regulation of histone acetylation and apoptosis by trichostatin in HL-60 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15791844 |
| Kang J et al. | Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. | 2005 | Biochem. Pharmacol. | pmid:15794941 |
| Narayanan R et al. | Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. | 2005 | Mol. Cell. Biol. | pmid:15798179 |
| Xiong Y et al. | Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. | 2005 | Cancer Res. | pmid:15805266 |
| Kumakura S et al. | Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. | 2005 | Cancer Res. | pmid:15805278 |
| Zhao W et al. | The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. | 2005 | J. Biochem. | pmid:15809347 |
| Komata T et al. | Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. | 2005 | Int. J. Oncol. | pmid:15809727 |
| Blais M et al. | Synergy between deacetylase inhibitors and IL-1beta in activation of the serum amyloid A2 gene promoter. | 2005 | DNA Cell Biol. | pmid:15812237 |
| Young DA et al. | Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. | 2005 | FEBS J. | pmid:15819885 |
| Xu S et al. | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. | 2005 | J. Hum. Genet. | pmid:15824892 |
| Strait KA et al. | Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. | 2005 | Mol. Cancer Ther. | pmid:15827334 |
| Magner WJ and Tomasi TB | Apoptotic and necrotic cells induced by different agents vary in their expression of MHC and costimulatory genes. | 2005 | Mol. Immunol. | pmid:15829293 |
| Gonçalves J et al. | Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells. | 2005 | Clin. Chem. Lab. Med. | pmid:15843208 |
| Robbins AR et al. | Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin. | 2005 | Cell Cycle | pmid:15846093 |
| Taghiyev AF et al. | Trichostatin A (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment. | 2005 | Cancer Biol. Ther. | pmid:15846101 |
| Barki-Celli L et al. | Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements. | 2005 | Genes Chromosomes Cancer | pmid:15846776 |
| Song Y et al. | [The mechanisms of p21WAF1/Cip-1 expression in MOLT-4 cell line induced by TSA]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15854272 |
| Xu ZM et al. | [Analysis of the methylation in the promoter of LRP15 gene and its expression]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15854274 |
| Mai A et al. | Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. | 2005 | J. Med. Chem. | pmid:15857140 |
| Galfi P et al. | Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862948 |
| Choi KH et al. | Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine. | 2005 | Glycoconj. J. | pmid:15864436 |
| Touma SE et al. | Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. | 2005 | Clin. Cancer Res. | pmid:15867260 |
| Fish JE et al. | The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. | 2005 | J. Biol. Chem. | pmid:15870070 |
| Dyson MH et al. | MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. | 2005 | J. Cell. Sci. | pmid:15870105 |
| Reid G et al. | Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. | 2005 | Oncogene | pmid:15870696 |
| Kim MS et al. | Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). | 2005 | Exp. Cell Res. | pmid:15878336 |
| Rosenqvist N et al. | Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain. | 2005 | Cell Transplant | pmid:15881422 |
| Camelo S et al. | Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. | 2005 | J. Neuroimmunol. | pmid:15885809 |
| Peltonen K et al. | Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis. | 2005 | Pigment Cell Res. | pmid:15892716 |
| Schwahn DJ et al. | Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. | 2005 | Pigment Cell Res. | pmid:15892717 |
| Ho WC et al. | Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. | 2005 | Cancer Res. | pmid:15899819 |
| Tran T et al. | Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. | 2005 | Cancer Res. | pmid:15899836 |
| Gurvich N et al. | Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. | 2005 | FASEB J. | pmid:15901671 |
| Ranganathan P and Rangnekar VM | Exploiting the TSA connections to overcome apoptosis-resistance. | 2005 | Cancer Biol. Ther. | pmid:15908800 |
| Rincón-Arano H et al. | YY1 and GATA-1 interaction modulate the chicken 3'-side alpha-globin enhancer activity. | 2005 | J. Mol. Biol. | pmid:15913647 |
| Law RD and Suttle JC | Chromatin remodeling in plant cell culture: patterns of DNA methylation and histone H3 and H4 acetylation vary during growth of asynchronous potato cell suspensions. | 2005 | Plant Physiol. Biochem. | pmid:15922608 |
| Seo H et al. | Rapid generation of specific antibodies by enhanced homologous recombination. | 2005 | Nat. Biotechnol. | pmid:15924134 |
| Gray SG et al. | Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. | 2005 | J. Biol. Chem. | pmid:15927959 |
| Gunin AG et al. | Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. | 2005 | J. Endocrinol. | pmid:15930180 |
| Wittich S et al. | Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. | 2005 | Anticancer Drugs | pmid:15930892 |