trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu TC et al. | Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22626855 |
| Kim YS et al. | Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22634317 |
| Londhe P et al. | CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells. | 2012 | Int. J. Cancer | pmid:21989738 |
| Anh TD et al. | The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis in YD-10B oral squamous carcinoma cells. | 2012 | Oncol. Rep. | pmid:21993600 |
| Gillespie J et al. | Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. | 2012 | Arthritis Rheum. | pmid:21952924 |
| Grabiec AM et al. | Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. | 2012 | Ann. Rheum. Dis. | pmid:21953341 |
| Maroni P et al. | Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23085045 |
| Icardi L et al. | Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2. | 2012 | FASEB J. | pmid:21957129 |
| Dar RD et al. | Transcriptional burst frequency and burst size are equally modulated across the human genome. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23064634 |
| Yang Q et al. | Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23043075 |
| Fan H et al. | Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. | 2012 | Epigenetics | pmid:23092945 |
| Duncan HF et al. | Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. | 2012 | J Endod | pmid:22341071 |
| Kohda T et al. | Gene expression profile normalization in cloned mice by trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22257163 |
| Drzewiecka H and Jagodzinski PP | Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22257695 |
| Shah S et al. | Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression. | 2012 | Cancer Res. | pmid:22258452 |
| Cho JS et al. | Epigenetic regulation of myofibroblast differentiation and extracellular matrix production in nasal polyp-derived fibroblasts. | 2012 | Clin. Exp. Allergy | pmid:22239687 |
| Börner C et al. | Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. | 2012 | Neuroimmunomodulation | pmid:22262103 |
| Francisco R et al. | Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | 2012 | Cancer Lett. | pmid:22186300 |
| Sakuma Y et al. | WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. | 2012 | Lab. Invest. | pmid:22157722 |
| Chang J et al. | Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. | 2012 | Br. J. Cancer | pmid:22158273 |
| Calfa G et al. | HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. | 2012 | Hippocampus | pmid:22161912 |
| Horvat T et al. | Epigenetic modulation of the HeLa cell membrane N-glycome. | 2012 | Biochim. Biophys. Acta | pmid:22192783 |
| Shen YC et al. | The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. | 2012 | Dev. Biol. | pmid:22210003 |
| Zhang CZ et al. | Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma. | 2012 | Cell Cycle | pmid:22214764 |
| Kadowaki M et al. | DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. | 2012 | Int. J. Cancer | pmid:21437897 |
| Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
| Tu Z et al. | The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression. | 2012 | Mol. Cell. Biochem. | pmid:22476901 |
| Halsall J et al. | Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. | 2012 | PLoS ONE | pmid:22479401 |
| Huang D et al. | A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study. | 2012 | Eur J Med Chem | pmid:22465091 |
| Chuma M et al. | Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer. | 2012 | Biol. Pharm. Bull. | pmid:22466564 |
| Li J et al. | Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. | 2012 | Nat. Med. | pmid:22466704 |
| Majumdar G et al. | Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. | 2012 | BMC Genomics | pmid:23249388 |
| Glait-Santar C et al. | Expression pattern of SVEP1 alternatively-spliced forms. | 2012 | Gene | pmid:22659106 |
| Xiong H et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. | 2012 | Mol. Carcinog. | pmid:21520296 |
| Park J et al. | ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22580278 |
| Yin Z et al. | Position effect variegation and epigenetic modification of a transgene in a pig model. | 2012 | Genet. Mol. Res. | pmid:22370938 |
| Halldórsdóttir AM et al. | Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. | 2012 | Am. J. Hematol. | pmid:22374828 |
| Schnichels S et al. | Trichostatin A induces cell death at the concentration recommended to differentiate the RGC-5 cell line. | 2012 | Neurochem. Int. | pmid:22391323 |
| Chan JN et al. | Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. | 2012 | Mol. Cell Proteomics | pmid:22357554 |
| Li L et al. | Regulation of histone acetylation by NDRG2 in glioma cells. | 2012 | J. Neurooncol. | pmid:21912936 |
| Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
| Jee BC et al. | Effect of trichostatin A on fertilization and embryo development during extended culture of mouse oocyte. | 2012 | Zygote | pmid:21269543 |
| SustáÄková G et al. | Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. | 2012 | J. Cell. Physiol. | pmid:21732356 |
| Zhang QC et al. | Histone deacetylase inhibitor trichostatin A enhances anti-tumor effects of docetaxel or erlotinib in A549 cell line. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22994780 |
| Nepelska M et al. | Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. | 2012 | PLoS ONE | pmid:23300800 |
| He M and Guo Q | [Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22561570 |
| Catalano MG et al. | Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22563106 |
| Yu L et al. | Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis. | 2012 | Arch. Med. Res. | pmid:22564421 |
| Bobkov DE et al. | [Isolation of tropomyosin particles from the cytosol of cultured cells and their protein composition analysis]. | 2012 | Tsitologiia | pmid:22567898 |
| Li Q and Chen H | Silencing of Wnt5a during colon cancer metastasis involves histone modifications. | 2012 | Epigenetics | pmid:22522911 |